KEGG   DISEASE: 甲状腺癌
エントリ  
H00032                                                             
名称    
甲状腺癌
  下位グループ
非髄様甲状腺癌 (NMTC)
  上位グループ
固形腫瘍 [DS:H02421]
概要    
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  内分泌器官のがん
   H00032  甲状腺癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    内分泌腺の悪性腫瘍
     2D10  甲状腺の悪性腫瘍
      H00032  甲状腺癌
パスウェイ 
hsa05216  甲状腺癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
ネットワーク
nt06274  Thyroid cancer
病因遺伝子 
RET/CCDC6 (rearrangement) [HSA:5979 8030] [KO:K05126 K09288]
RET/NCOA4 (rearrangement) [HSA:5979 8031] [KO:K05126 K09289]
TPM3/NTRK1 (rearrangement) [HSA:4914 7170] [KO:K03176 K09290]
TPR/NTRK1 (rearrangement) [HSA:7175 7170] [KO:K09291 K09290]
TFG/NTRK1 (rearrangement) [HSA:10342 7170] [KO:K09292 K09290]
PAX8/PPARG (rearrangement) [HSA:7849 5468] [KO:K09293 K08530]
KRAS [HSA:3845] [KO:K07827]
HRAS [HSA:3265] [KO:K02833]
NRAS [HSA:4893] [KO:K07828]
BRAF [HSA:673] [KO:K04365]
CTNNB1 [HSA:1499] [KO:K02105]
TP53 [HSA:7157] [KO:K04451]
CDH1 [HSA:999] [KO:K05689]
MINPP1 [HSA:9562] [KO:K03103]
(NMTC1) NKX2-1 [HSA:7080] [KO:K09342]
(NMTC2) SRGAP1 [HSA:57522] [KO:K07526]
(NMTC4) FOXE1 [HSA:2304] [KO:K09398]
(NMTC5) HABP2 [HSA:3026] [KO:K08648]
発癌物質  
Radium-224 and its decay products [CPD:C16455]
Radioiodines, short-lived isotopes, including iodine131, from atomic reactor accidents and nuclear
治療薬   
ブレオマイシン塩酸塩 [DR:D03229]
ソラフェニブトシル酸塩 [DR:D06272]
レンバチニブメシル酸塩 [DR:D09920]
セルペルカチニブ [DR:D11713] (RET融合遺伝子陽性)
ストレプトコックス・ピオゲネス(A群3型)Su株ペニシリン処理凍結乾燥粉末 [DR:D08756]
ヨウ化ナトリウム (131I) [DR:D02259]
リンク   
ICD-11: 2D10
ICD-10: C73
MeSH: D013964
OMIM: 188550 188470 616534 616535
文献    
  著者
Gimm O.
  タイトル
Thyroid cancer.
  雑誌
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
文献    
PMID:16557281 (RET/CCDC6, TPM3/NTRK1, TPR/NTRK1, TFG/NTRK1, BRAF, CTNNB1, TP53, CDH1)
  著者
Kondo T, Ezzat S, Asa SL.
  タイトル
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  雑誌
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
文献    
PMID:16189702 (RET/CCDC6, RET/NCOA4, PAX8/PPARG, KRAS, HRAS, NRAS)
  著者
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  タイトル
Molecular pathology of well-differentiated thyroid carcinomas.
  雑誌
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
文献    
PMID:11297621 (MINPP1)
  著者
Gimm O, Chi H, Dahia PL, Perren A, Hinze R, Komminoth P, Dralle H, Reynolds PR, Eng C
  タイトル
Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.
  雑誌
J Clin Endocrinol Metab 86:1801-5 (2001)
DOI:10.1210/jcem.86.4.7419
文献    
PMID:19176457 (NMTC1)
  著者
Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barcelo MM
  タイトル
A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.
  雑誌
J Natl Cancer Inst 101:162-75 (2009)
DOI:10.1093/jnci/djn471
文献    
PMID:23539728 (NMTC2)
  著者
He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, Akagi K, Saji M, Kula D, Wojcicka A, Sebastian N, Wen B, Puch Z, Kalemba M, Stachlewska E, Czetwertynska M, Dlugosinska J, Dymecka K, Ploski R, Krawczyk M, Morrison PJ, Ringel MD, Kloos RT, Jazdzewski K, Symer DE, Vieland VJ, Ostrowski M, Jarzab B, de la Chapelle A
  タイトル
SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.
  雑誌
J Clin Endocrinol Metab 98:E973-80 (2013)
DOI:10.1210/jc.2012-3823
文献    
PMID:25381600 (NMTC4)
  著者
Pereira JS, da Silva JG, Tomaz RA, Pinto AE, Bugalho MJ, Leite V, Cavaco BM
  タイトル
Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC).
  雑誌
Endocrine 49:204-14 (2015)
DOI:10.1007/s12020-014-0470-0
文献    
PMID:26222560 (NMTC5)
  著者
Gara SK, Jia L, Merino MJ, Agarwal SK, Zhang L, Cam M, Patel D, Kebebew E
  タイトル
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.
  雑誌
N Engl J Med 373:448-55 (2015)
DOI:10.1056/NEJMoa1502449
LinkDB    

» English version

DBGET integrated database retrieval system