KEGG   PATHWAY: dsi04141
Entry
dsi04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Drosophila simulans
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dsi04141  Protein processing in endoplasmic reticulum
dsi04141

Other DBs
GO: 0030433 0034976
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD10041  Dsim_GD10041; uncharacterized protein, isoform B [KO:K14007]
Dsimw501_GD10253  Dsim_GD10253; uncharacterized protein [KO:K14012]
Dsimw501_GD10282  Dsim_GD10282; uncharacterized protein [KO:K09518]
Dsimw501_GD10391  Dsim_GD10391; uncharacterized protein [KO:K01456] [EC:3.5.1.52]
Dsimw501_GD10516  Dsim_GD10516; uncharacterized protein [KO:K03347]
Dsimw501_GD10555  Dsim_GD10555; uncharacterized protein, isoform B [KO:K05546] [EC:3.2.1.207]
Dsimw501_GD10608  Dsim_GD10608; uncharacterized protein, isoform C [KO:K14005]
Dsimw501_GD10706  Dsim_GD10706; uncharacterized protein, isoform A [KO:K13525]
Dsimw501_GD11014  Dsim_GD11014; uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dsimw501_GD11064  Dsim_GD11064; uncharacterized protein [KO:K09481]
Dsimw501_GD11437  Dsim_GD11437; uncharacterized protein [KO:K09586]
Dsimw501_GD11567  Dsim_GD11567; uncharacterized protein [KO:K09027]
Dsimw501_GD11958  Dsim_GD11958; uncharacterized protein, isoform A [KO:K10575] [EC:2.3.2.23]
Dsimw501_GD12102  Dsim_GD12102; uncharacterized protein [KO:K08653] [EC:3.4.21.112]
Dsimw501_GD12138  Dsim_GD12138; uncharacterized protein, isoform B [KO:K04556] [EC:2.3.2.31]
Dsimw501_GD12439  Dsim_GD12439; uncharacterized protein, isoform A [KO:K26502]
Dsimw501_GD12558  Dsim_GD12558; uncharacterized protein, isoform A [KO:K09556]
Dsimw501_GD12572  Dsim_GD12572; uncharacterized protein [KO:K09580] [EC:5.3.4.1]
Dsimw501_GD12683  Dsim_GD12683; uncharacterized protein [KO:K03347]
Dsimw501_GD12702  Dsim_GD12702; uncharacterized protein [KO:K09562]
Dsimw501_GD12819  Dsim_GD12819; uncharacterized protein [KO:K14016]
Dsimw501_GD13028  Dsim_GD13028; uncharacterized protein [KO:K24348]
Dsimw501_GD13323  Dsim_GD13323; uncharacterized protein, isoform B [KO:K06689] [EC:2.3.2.23]
Dsimw501_GD13395  Dsim_GD13395; uncharacterized protein, isoform A [KO:K10661] [EC:2.3.2.27]
Dsimw501_GD13575  Dsim_GD13575; uncharacterized protein, isoform A [KO:K14009]
Dsimw501_GD13739  Dsim_Hsp83; heat shock protein 83 [KO:K04079]
Dsimw501_GD13876  Dsim_GD13876; uncharacterized protein [KO:K13719] [EC:3.1.2.-]
Dsimw501_GD14009  Dsim_GD14009; uncharacterized protein [KO:K09540]
Dsimw501_GD14045  Dsim_GD14045; uncharacterized protein [KO:K24348]
Dsimw501_GD14102  Dsim_GD14102; uncharacterized protein [KO:K10080]
Dsimw501_GD14170  Dsim_GD14170; uncharacterized protein [KO:K14014]
Dsimw501_GD14466  Dsim_GD14466; uncharacterized protein, isoform A [KO:K03283]
Dsimw501_GD14475  Dsim_GD14475; uncharacterized protein, isoform C [KO:K09485]
Dsimw501_GD14599  Dsim_GD14599; uncharacterized protein [KO:K13250]
Dsimw501_GD14778  Dsim_GD14778; uncharacterized protein [KO:K11718] [EC:2.4.1.-]
Dsimw501_GD15244  Dsim_GD15244; uncharacterized protein [KO:K07342]
Dsimw501_GD15599  Dsim_GD15599; uncharacterized protein [KO:K09521]
Dsimw501_GD15746  Dsim_GD15746; uncharacterized protein [KO:K08054]
Dsimw501_GD15749  Dsim_GD15749; uncharacterized protein [KO:K03237]
Dsimw501_GD15764  Dsim_GD15764; uncharacterized protein [KO:K04523]
Dsimw501_GD15775  Dsim_GD15775; uncharacterized protein, isoform B [KO:K10666] [EC:2.3.2.27]
Dsimw501_GD15909  Dsim_GD15909; uncharacterized protein, isoform D [KO:K04431] [EC:2.7.12.2]
Dsimw501_GD15935  Dsim_GD15935; uncharacterized protein [KO:K08054]
Dsimw501_GD15970  Dsim_GD15970; uncharacterized protein, isoform B [KO:K09490] [EC:3.6.4.10]
Dsimw501_GD15993  Dsim_GD15993; uncharacterized protein [KO:K01228] [EC:3.2.1.106]
Dsimw501_GD16081  Dsim_GD16081; uncharacterized protein [KO:K12670]
Dsimw501_GD16375  Dsim_GD16375; uncharacterized protein [KO:K09486]
Dsimw501_GD16401  Dsim_GD16401; uncharacterized protein [KO:K10085]
Dsimw501_GD16520  Dsim_GD16520; uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dsimw501_GD16521  Dsim_GD16521; uncharacterized protein, isoform A [KO:K03094]
Dsimw501_GD16534  Dsim_GD16534; uncharacterized protein [KO:K14010]
Dsimw501_GD16961  Dsim_GD16961; uncharacterized protein [KO:K13249]
Dsimw501_GD17042  Dsim_GD17042; uncharacterized protein [KO:K13984] [EC:5.3.4.1]
Dsimw501_GD17469  Dsim_GD17469; uncharacterized protein [KO:K03094]
Dsimw501_GD17476  Dsim_GD17476; uncharacterized protein [KO:K09054]
Dsimw501_GD17544  Dsim_GD17544; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
Dsimw501_GD17653  Dsim_GD17653; uncharacterized protein, isoform C [KO:K09525]
Dsimw501_GD17820  Dsim_GD17820; uncharacterized protein, isoform C [KO:K08054]
Dsimw501_GD17996  Dsim_GD17996; uncharacterized protein [KO:K23741]
Dsimw501_GD18187  Dsim_GD18187; uncharacterized protein, isoform B [KO:K14015]
Dsimw501_GD18223  Dsim_GD18223; uncharacterized protein [KO:K14001]
Dsimw501_GD18237  Dsim_GD18237; uncharacterized protein [KO:K07151] [EC:2.4.99.18]
Dsimw501_GD18315  Dsim_GD18315; uncharacterized protein [KO:K10082]
Dsimw501_GD18326  Dsim_Hsp68; Hsp68 [KO:K03283]
Dsimw501_GD18357  Dsim_GD18357; uncharacterized protein [KO:K14026]
Dsimw501_GD18439  Dsim_GD18439; uncharacterized protein, isoform B [KO:K14020]
Dsimw501_GD18549  Dsim_GD18549; uncharacterized protein [KO:K28202]
Dsimw501_GD18630  Dsim_GD18630; uncharacterized protein, isoform A [KO:K09523]
Dsimw501_GD18878  Dsim_GD18878; uncharacterized protein [KO:K03283]
Dsimw501_GD18906  Dsim_GD18906; uncharacterized protein, isoform A [KO:K09502]
Dsimw501_GD18942  Dsim_GD18942; uncharacterized protein, isoform B [KO:K09518]
Dsimw501_GD18998  Dsim_Hsc70-4; Hsc70-4 [KO:K03283]
Dsimw501_GD19320  Dsim_GD19320; uncharacterized protein [KO:K04426] [EC:2.7.11.25]
Dsimw501_GD19618  Dsim_GD19618; uncharacterized protein, isoform D [KO:K08860] [EC:2.7.11.1]
Dsimw501_GD19730  Dsim_GD19730; uncharacterized protein [KO:K04523]
Dsimw501_GD19806  Dsim_GD19806; uncharacterized protein [KO:K14006]
Dsimw501_GD20099  Dsim_GD20099; uncharacterized protein [KO:K08852] [EC:2.7.11.1 3.1.26.-]
Dsimw501_GD20228  Dsim_GD20228; uncharacterized protein [KO:K04554] [EC:2.3.2.23]
Dsimw501_GD20283  Dsim_GD20283; uncharacterized protein [KO:K13989]
Dsimw501_GD20402  Dsim_GD20402; uncharacterized protein [KO:K06689] [EC:2.3.2.23]
Dsimw501_GD20475  Dsim_GD20475; uncharacterized protein [KO:K10575] [EC:2.3.2.23]
Dsimw501_GD20560  Dsim_Hsp70Ba; Hsp70Ba [KO:K03283]
Dsimw501_GD20621  Dsim_Hsp70Aa; Heat-shock-protein-70Aa [KO:K03283]
Dsimw501_GD20777  Dsim_GD20777; uncharacterized protein [KO:K08057]
Dsimw501_GD20936  Dsim_GD20936; uncharacterized protein, isoform A [KO:K07953] [EC:3.6.5.-]
Dsimw501_GD21013  Dsim_GD21013; uncharacterized protein [KO:K14004]
Dsimw501_GD21063  Dsim_GD21063; uncharacterized protein [KO:K10839]
Dsimw501_GD21359  Dsim_GD21359; uncharacterized protein [KO:K09487]
Dsimw501_GD21603  Dsim_GD21603; uncharacterized protein [KO:K10601] [EC:2.3.2.27]
Dsimw501_GD21864  Dsim_GD21864; uncharacterized protein [KO:K08288]
Dsimw501_GD21912  Dsim_GD21912; uncharacterized protein [KO:K09584] [EC:5.3.4.1]
Dsimw501_GD22085  Dsim_GD22085; uncharacterized protein [KO:K09503]
Dsimw501_GD22092  Dsim_GD22092; uncharacterized protein, isoform A [KO:K10597] [EC:2.3.2.27]
Dsimw501_GD22141  Dsim_GD22141; uncharacterized protein [KO:K14008]
Dsimw501_GD22265  Dsim_GD22265; uncharacterized protein [KO:K12666]
Dsimw501_GD22289  Dsim_GD22289; uncharacterized protein [KO:K04440] [EC:2.7.11.24]
Dsimw501_GD22325  Dsim_GD22325; uncharacterized protein [KO:K13251]
Dsimw501_GD22410  Dsim_GD22410; uncharacterized protein [KO:K12668]
Dsimw501_GD22422  Dsim_GD22422; uncharacterized protein [KO:K19478]
Dsimw501_GD22572  Dsim_GD22572; uncharacterized protein [KO:K10956]
Dsimw501_GD22598  Dsim_GD22598; uncharacterized protein [KO:K14003]
Dsimw501_GD22760  Dsim_GD22760; uncharacterized protein [KO:K26501]
Dsimw501_GD22860  Dsim_GD22860; uncharacterized protein [KO:K14007]
Dsimw501_GD22906  Dsim_GD22906; uncharacterized protein [KO:K13984] [EC:5.3.4.1]
Dsimw501_GD22922  Dsim_GD22922; uncharacterized protein [KO:K14018]
Dsimw501_GD23027  Dsim_GD23027; uncharacterized protein [KO:K09517]
Dsimw501_GD23120  Dsim_GD23120; uncharacterized protein [KO:K11519]
Dsimw501_GD23649  Dsim_GD23649; uncharacterized protein, isoform B [KO:K12275]
Dsimw501_GD23704  Dsim_CHIP; CHIP [KO:K09561] [EC:2.3.2.27]
Dsimw501_GD23871  Dsim_GD23871; uncharacterized protein, isoform A [KO:K10086]
Dsimw501_GD24316  Dsim_GD24316; uncharacterized protein, isoform D [KO:K04374]
Dsimw501_GD24402  Dsim_Rad23; Rad23 [KO:K10839]
Dsimw501_GD24643  Dsim_GD24643; uncharacterized protein [KO:K07151] [EC:2.4.99.18]
Dsimw501_GD24646  Dsim_GD24646; uncharacterized protein, isoform B [KO:K01230] [EC:3.2.1.113]
Dsimw501_GD24840  Dsim_GD24840; uncharacterized protein [KO:K04555] [EC:2.3.2.23]
Dsimw501_GD24956  Dsim_GD24956; uncharacterized protein [KO:K14012]
Dsimw501_GD25016  Dsim_GD25016; uncharacterized protein [KO:K03094]
Dsimw501_GD25025  Dsim_GD25025; uncharacterized protein [KO:K09542]
Dsimw501_GD25046  Dsim_GD25046; uncharacterized protein [KO:K03094]
Dsimw501_GD25279  Dsim_GD25279; uncharacterized protein [KO:K07342]
Dsimw501_GD25372  Dsim_GD25372; uncharacterized protein, isoform A [KO:K14011]
Dsimw501_GD25442  Dsim_GD25442; uncharacterized protein [KO:K12667]
Dsimw501_GD25859  Dsim_GD25859; uncharacterized protein [KO:K03094]
Dsimw501_GD25877  Dsim_ERp60; ERp60 [KO:K08056] [EC:5.3.4.1]
Dsimw501_GD25883  Dsim_GD25883; uncharacterized protein [KO:K07765] [EC:3.4.24.85]
Dsimw501_GD25906  Dsim_GD25906; uncharacterized protein [KO:K04571]
Dsimw501_GD27473  Dsim_GD27473; uncharacterized protein [KO:K07342]
Dsimw501_GD28835  Dsim_GD28835; uncharacterized protein [KO:K10950] [EC:1.8.4.-]
Dsimw501_GD29572  Dsim_GD29572; uncharacterized protein [KO:K03094]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dsi00510  N-Glycan biosynthesis
dsi03050  Proteasome
dsi03060  Protein export
KO pathway
ko04141   

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