KEGG   PATHWAY: dso00260
Entry
dso00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Dickeya solani IPO 2222
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
dso00260  Glycine, serine and threonine metabolism
dso00260

Module
dso_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:dso00260]
dso_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:dso00260]
dso_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:dso00260]
dso_M00555  Betaine biosynthesis, choline => betaine [PATH:dso00260]
dso_M00621  Glycine cleavage system [PATH:dso00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Dickeya solani IPO 2222 [GN:dso]
Gene
A4U42_06565  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
A4U42_05870  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
A4U42_07850  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
A4U42_07350  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A4U42_05865  homoserine kinase [KO:K00872] [EC:2.7.1.39]
A4U42_05860  threonine synthase [KO:K01733] [EC:4.2.3.1]
A4U42_03235  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A4U42_16910  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
A4U42_09330  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
A4U42_04580  glycerate kinase [KO:K00865] [EC:2.7.1.165]
A4U42_15470  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
A4U42_05895  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
A4U42_05935  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A4U42_13870  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A4U42_18610  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
A4U42_09210  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
A4U42_11565  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
A4U42_19615  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
A4U42_01560  aminotransferase [KO:K00639] [EC:2.3.1.29]
A4U42_09950  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
A4U42_09955  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
A4U42_12485  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
A4U42_12475  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A4U42_05375  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A4U42_12480  glycine cleavage system protein H [KO:K02437]
A4U42_04355  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
A4U42_01130  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
A4U42_01135  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A4U42_20735  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
A4U42_20740  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
A4U42_02730  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A4U42_20245  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A4U42_07725  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A4U42_12820  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
A4U42_19390  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A4U42_19395  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A4U42_16790  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
dso00010  Glycolysis / Gluconeogenesis
dso00020  Citrate cycle (TCA cycle)
dso00230  Purine metabolism
dso00250  Alanine, aspartate and glutamate metabolism
dso00270  Cysteine and methionine metabolism
dso00290  Valine, leucine and isoleucine biosynthesis
dso00300  Lysine biosynthesis
dso00330  Arginine and proline metabolism
dso00460  Cyanoamino acid metabolism
dso00470  D-Amino acid metabolism
dso00564  Glycerophospholipid metabolism
dso00600  Sphingolipid metabolism
dso00620  Pyruvate metabolism
dso00630  Glyoxylate and dicarboxylate metabolism
dso00640  Propanoate metabolism
dso00680  Methane metabolism
dso00860  Porphyrin metabolism
dso00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system