KEGG   PATHWAY: ecs00260
Entry
ecs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli O157:H7 Sakai (EHEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ecs00260  Glycine, serine and threonine metabolism
ecs00260

Module
ecs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecs00260]
ecs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ecs00260]
ecs_M00555  Betaine biosynthesis, choline => betaine [PATH:ecs00260]
ecs_M00621  Glycine cleavage system [PATH:ecs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli O157:H7 Sakai (EHEC) [GN:ecs]
Gene
ECs_0002  thrA; aspartokinase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
ECs_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
ECs_0004  thrC; L-threonine synthase [KO:K01733] [EC:4.2.3.1]
ECs_0120  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ECs_0357  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ECs_0358  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ECs_0576  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECs_0783  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
ECs_0956  ltaE; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ECs_0990  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
ECs_1410  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECs_1832  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ECs_1833  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ECs_2148  ydfG; NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ECs_2523  tdcG_1; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
ECs_3245  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
ECs_3417  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECs_3452  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
ECs_3657  tdcG_2; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
ECs_3697  ygeA; aspartate/glutamate racemase [KO:K25316]
ECs_3774  gcvP; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
ECs_3775  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECs_3776  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ECs_3784  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ECs_3992  tdcG_3; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
ECs_3997  tdcB; L-threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ECs_4002  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECs_4278  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ECs_4438  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECs_4490  gpmM; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
ECs_4494  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
ECs_4495  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
ECs_4706  ilvA; l-threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ECs_4869  metL; aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
ECs_5007  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
ECs_5346  serB; 3-phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
ECs_5353  ytjC; phosphatase [KO:K15634] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ecs00010  Glycolysis / Gluconeogenesis
ecs00020  Citrate cycle (TCA cycle)
ecs00230  Purine metabolism
ecs00250  Alanine, aspartate and glutamate metabolism
ecs00270  Cysteine and methionine metabolism
ecs00290  Valine, leucine and isoleucine biosynthesis
ecs00300  Lysine biosynthesis
ecs00330  Arginine and proline metabolism
ecs00460  Cyanoamino acid metabolism
ecs00470  D-Amino acid metabolism
ecs00564  Glycerophospholipid metabolism
ecs00600  Sphingolipid metabolism
ecs00620  Pyruvate metabolism
ecs00630  Glyoxylate and dicarboxylate metabolism
ecs00640  Propanoate metabolism
ecs00680  Methane metabolism
ecs00860  Porphyrin metabolism
ecs00920  Sulfur metabolism
KO pathway
ko00260   

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