KEGG PATHWAY: ecv00260

PATHWAY: ecv00260

Entry

ecv00260                    Pathway

Name

Glycine, serine and threonine metabolism - Escherichia coli APEC O1 (APEC)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ecv00260

Glycine, serine and threonine metabolism

Module

ecv_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecv00260]

ecv_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ecv00260]

ecv_M00555

Betaine biosynthesis, choline => betaine [PATH:ecv00260]

ecv_M00621

Glycine cleavage system [PATH:ecv00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Escherichia coli APEC O1 (APEC) [GN:ecv]

Gene

APECO1_118

ycdW; putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]

APECO1_1224

ybjU; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

APECO1_1333

gpmA; Phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

APECO1_1501

glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]

APECO1_1678

betB; betaine aldehyde dehydrogenase, NAD-dependent [KO:K00130] [EC:1.2.1.8]

APECO1_1679

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

APECO1_1869

lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

APECO1_19

serC; SerC [KO:K00831] [EC:2.6.1.52]

APECO1_1974

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

APECO1_1975

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

APECO1_1976

thrA; bifunctional aspartokinase I/homeserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]

APECO1_1984

gpmB; putative phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]

APECO1_1993

serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

APECO1_2098

gclK; putative glycerate kinase GclK [KO:K00865] [EC:2.7.1.165]

APECO1_2408

[KO:K00382] [EC:1.8.1.4]

APECO1_2444

lysC; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]

APECO1_2531

metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]

APECO1_2699

ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]

APECO1_2838

kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]

APECO1_2839

tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]

APECO1_2843

yibO; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

APECO1_2895

tkrA; 2-ketoaldonate reductase/glyoxylate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

APECO1_3024

asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]

APECO1_3303

garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]

APECO1_3307

tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]

APECO1_3312

tdcG; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]

APECO1_3616

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

APECO1_3623

gcvT; putative aminomethyltransferase of glycine cleavage system [KO:K00605] [EC:2.1.2.10]

APECO1_3624

gcvH; glycine cleavage system protein H [KO:K02437]

APECO1_3625

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

APECO1_3666

ygeA; conserved hypothetical protein [KO:K25316]

APECO1_3693

[KO:K00058] [EC:1.1.1.95 1.1.1.399]

APECO1_3734

sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]

APECO1_3947

pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998] [EC:2.7.8.8]

APECO1_3980

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

APECO1_4170

dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]

APECO1_421

trpA; tryptophan synthase alpha subunit [KO:K01695] [EC:4.2.1.20]

APECO1_422

trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]

APECO1_6592

ydfG; putative oxidoreductase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]

APECO1_871

sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721