KEGG   PATHWAY: ehu00260
Entry
ehu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacter huaxiensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ehu00260  Glycine, serine and threonine metabolism
ehu00260

Module
ehu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ehu00260]
ehu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ehu00260]
ehu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ehu00260]
ehu_M00555  Betaine biosynthesis, choline => betaine [PATH:ehu00260]
ehu_M00621  Glycine cleavage system [PATH:ehu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacter huaxiensis [GN:ehu]
Gene
D5067_0021920  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
D5067_0019645  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
D5067_0022755  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
D5067_0001565  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
D5067_0019640  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
D5067_0019635  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
D5067_0015380  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
D5067_0006175  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
D5067_0014450  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
D5067_0022250  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
D5067_0003000  garK; glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
D5067_0004760  glycerate kinase [KO:K00865] [EC:2.7.1.165]
D5067_0011225  glycerate kinase [KO:K11529] [EC:2.7.1.165]
D5067_0016150  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
D5067_0019695  gpmB; phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
D5067_0000735  gpmM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
D5067_0004145  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
D5067_0015200  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
D5067_0019740  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
D5067_0012520  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
D5067_0000705  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
D5067_0000710  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
D5067_0012440  tynA; primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
D5067_0004195  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
D5067_0004185  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
D5067_0019105  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D5067_0004190  gcvH; glycine cleavage system protein GcvH [KO:K02437]
D5067_0006000  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
D5067_0016970  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
D5067_0016965  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
D5067_0013340  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
D5067_0013345  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
D5067_0004700  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
D5067_0009540  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
D5067_0022560  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
D5067_0003015  tdcB; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB [KO:K01754] [EC:4.3.1.19]
D5067_0000115  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
D5067_0004500  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
D5067_0010285  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
D5067_0010290  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
D5067_0007910  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
D5067_0007905  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ehu00010  Glycolysis / Gluconeogenesis
ehu00020  Citrate cycle (TCA cycle)
ehu00230  Purine metabolism
ehu00250  Alanine, aspartate and glutamate metabolism
ehu00270  Cysteine and methionine metabolism
ehu00290  Valine, leucine and isoleucine biosynthesis
ehu00300  Lysine biosynthesis
ehu00330  Arginine and proline metabolism
ehu00460  Cyanoamino acid metabolism
ehu00470  D-Amino acid metabolism
ehu00564  Glycerophospholipid metabolism
ehu00600  Sphingolipid metabolism
ehu00620  Pyruvate metabolism
ehu00630  Glyoxylate and dicarboxylate metabolism
ehu00640  Propanoate metabolism
ehu00680  Methane metabolism
ehu00860  Porphyrin metabolism
ehu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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