KEGG   PATHWAY: ely03460
Entry
ely03460                    Pathway                                
Name
Fanconi anemia pathway - Epinephelus lanceolatus (giant grouper)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
ely03460  Fanconi anemia pathway
ely03460

Other DBs
GO: 0043240
Organism
Epinephelus lanceolatus (giant grouper) [GN:ely]
Gene
117246801  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
117246829  [KO:K07466]
117246887  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
117246907  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
117246959  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
117246966  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
117247828  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
117248250  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
117248534  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
117248608  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
117249174  rev1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
117251040  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
117251222  fancb; Fanconi anemia group B protein isoform X1 [KO:K10889]
117252248  polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
117252413  fancg; Fanconi anemia group G protein isoform X1 [KO:K10894]
117252525  poli; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
117252786  fancc; Fanconi anemia group C protein isoform X1 [KO:K10890]
117252837  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
117253593  her6; hairy-related 6 [KO:K06054]
117253822  usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 [KO:K11832] [EC:3.4.19.12]
117254800  palb2; partner and localizer of BRCA2 [KO:K10897]
117255322  slx4; structure-specific endonuclease subunit SLX4 [KO:K10484]
117256348  fancd2; Fanconi anemia group D2 protein [KO:K10891]
117256738  atrip; ATR-interacting protein isoform X1 [KO:K10905]
117256824  cenps; centromere protein S [KO:K11511]
117257863  her9; hairy-related 9 isoform X1 [KO:K06054]
117257924  fance; Fanconi anemia group E protein [KO:K10892]
117257978  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
117258804  ube2t; ubiquitin-conjugating enzyme E2 T isoform X1 [KO:K13960] [EC:2.3.2.23]
117259116  [KO:K10605] [EC:2.3.2.27]
117259301  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
117259595  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
117260311  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
117261581  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
117261609  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
117261805  fancf; Fanconi anemia group F protein [KO:K10893]
117261980  [KO:K10898]
117262345  fanci; Fanconi anemia group I protein [KO:K10895]
117262496  [KO:K10888]
117262632  [KO:K10898]
117263667  rpa3; replication protein A 14 kDa subunit [KO:K10740]
117264034  [KO:K10739]
117265811  rpa2; replication protein A 32 kDa subunit [KO:K10739]
117267351  fancm; Fanconi anemia group M protein [KO:K10896]
117267985  cenpx; centromere protein X [KO:K15360]
117268639  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
117268864  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
117270839  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
117271191  rev3l; DNA polymerase zeta catalytic subunit isoform X1 [KO:K02350] [EC:2.7.7.7]
117271792  [KO:K15361]
117272331  [KO:K06054]
117272789  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
117272847  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
117272864  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
ely03430  Mismatch repair
ely03440  Homologous recombination
KO pathway
ko03460   

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