KEGG   PATHWAY: enb00260
Entry
enb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacter sp. N18-03635
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
enb00260  Glycine, serine and threonine metabolism
enb00260

Module
enb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:enb00260]
enb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:enb00260]
enb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:enb00260]
enb_M00555  Betaine biosynthesis, choline => betaine [PATH:enb00260]
enb_M00621  Glycine cleavage system [PATH:enb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacter sp. N18-03635 [GN:enb]
Gene
ELK40_01995  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
ELK40_03950  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
ELK40_22070  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
ELK40_10425  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ELK40_21130  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ELK40_03955  homoserine kinase [KO:K00872] [EC:2.7.1.39]
ELK40_03960  threonine synthase [KO:K01733] [EC:4.2.3.1]
ELK40_07805  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
ELK40_16995  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ELK40_08640  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ELK40_01645  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ELK40_18395  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ELK40_07065  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
ELK40_03915  gpmB; phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
ELK40_01400  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
ELK40_18910  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ELK40_21345  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ELK40_07990  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
ELK40_03870  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ELK40_10560  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ELK40_01365  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
ELK40_01370  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
ELK40_10620  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
ELK40_18860  aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
ELK40_18870  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
ELK40_04440  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ELK40_18865  gcvH; glycine cleavage system protein GcvH [KO:K02437]
ELK40_17175  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
ELK40_06330  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ELK40_06335  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ELK40_09745  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
ELK40_09740  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
ELK40_13745  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
ELK40_18455  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
ELK40_19820  tdcB; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB [KO:K01754] [EC:4.3.1.19]
ELK40_21905  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
ELK40_00810  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
ELK40_18650  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
ELK40_13035  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
ELK40_13030  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
ELK40_15135  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
ELK40_15140  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
enb00010  Glycolysis / Gluconeogenesis
enb00020  Citrate cycle (TCA cycle)
enb00230  Purine metabolism
enb00250  Alanine, aspartate and glutamate metabolism
enb00270  Cysteine and methionine metabolism
enb00290  Valine, leucine and isoleucine biosynthesis
enb00300  Lysine biosynthesis
enb00330  Arginine and proline metabolism
enb00460  Cyanoamino acid metabolism
enb00470  D-Amino acid metabolism
enb00564  Glycerophospholipid metabolism
enb00600  Sphingolipid metabolism
enb00620  Pyruvate metabolism
enb00630  Glyoxylate and dicarboxylate metabolism
enb00640  Propanoate metabolism
enb00680  Methane metabolism
enb00860  Porphyrin metabolism
enb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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