KEGG   PATHWAY: eun00230
Entry
eun00230                    Pathway                                
Name
Purine metabolism - Escherichia coli UMNK88 (ETEC, porcine)
Class
Metabolism; Nucleotide metabolism
Pathway map
eun00230  Purine metabolism
eun00230

Module
eun_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eun00230]
eun_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eun00230]
eun_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eun00230]
eun_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eun00230]
eun_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eun00230]
eun_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eun00230]
eun_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eun00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli UMNK88 (ETEC, porcine) [GN:eun]
Gene
UMNK88_103  guaC; guanosine monophosphate reductase GuaC [KO:K00364] [EC:1.7.1.7]
UMNK88_1199  ureA; urease gamma subunit UreA [KO:K01430] [EC:3.5.1.5]
UMNK88_1200  ureB; urease beta subunit UreB [KO:K01429] [EC:3.5.1.5]
UMNK88_1201  ureC; urease alpha subunit UreC [KO:K01428] [EC:3.5.1.5]
UMNK88_124  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
UMNK88_1462  purB; adenylosuccinate lyase PurB [KO:K01756] [EC:4.3.2.2]
UMNK88_1523  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
UMNK88_164  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
UMNK88_2082  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
UMNK88_2320  purT; phosphoribosylglycinamide formyltransferase PurT [KO:K08289] [EC:6.3.1.21]
UMNK88_2447  uraH; hydroxyisourate hydrolase UraH [KO:K07127] [EC:3.5.2.17]
UMNK88_2504  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
UMNK88_272  [KO:K00769] [EC:2.4.2.22]
UMNK88_2783  [KO:K00525] [EC:1.17.4.1]
UMNK88_2784  [KO:K00526] [EC:1.17.4.1]
UMNK88_282  [KO:K06952] [EC:3.1.3.89]
UMNK88_2841  [KO:K08722] [EC:3.1.3.89]
UMNK88_2863  purF; amidophosphoribosyltransferase PurF [KO:K00764] [EC:2.4.2.14]
UMNK88_3008  xapA; xanthosine phosphorylase XapA [KO:K03783] [EC:2.4.2.1]
UMNK88_3071  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase PurC [KO:K01923] [EC:6.3.2.6]
UMNK88_3096  purM; phosphoribosylformylglycinamidine cyclo-ligase PurM [KO:K01933] [EC:6.3.3.1]
UMNK88_3097  purN; phosphoribosylglycinamide formyltransferase PurN [KO:K11175] [EC:2.1.2.2]
UMNK88_3099  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
UMNK88_3156  guaA; GMP synthase GuaA [KO:K01951] [EC:6.3.5.2]
UMNK88_3157  guaB; inosine-5'-monophosphate dehydrogenase GuaB [KO:K00088] [EC:1.1.1.205]
UMNK88_3168  [KO:K00940] [EC:2.7.4.6]
UMNK88_3210  purL; phosphoribosylformylglycinamidine synthase PurL [KO:K01952] [EC:6.3.5.3]
UMNK88_3248  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
UMNK88_332  [KO:K11177] [EC:1.17.1.4]
UMNK88_333  [KO:K11178] [EC:1.17.1.4]
UMNK88_334  [KO:K13483]
UMNK88_3344  [KO:K00525] [EC:1.17.4.1]
UMNK88_3345  [KO:K00526] [EC:1.17.4.1]
UMNK88_3419  surE; 5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
UMNK88_3426  cysC; adenylylsulfate kinase CysC [KO:K00860] [EC:2.7.1.25]
UMNK88_3427  cysN; bifunctional sulfate adenylyltransferase subunit 1 CysN [KO:K00956] [EC:2.7.7.4]
UMNK88_3428  cysD; sulfate adenylyltransferase subunit 2 CysD [KO:K00957] [EC:2.7.7.4]
UMNK88_3464  [KO:K04765] [EC:3.6.1.9]
UMNK88_3467  [KO:K00951] [EC:2.7.6.5]
UMNK88_3480  [KO:K06966] [EC:3.2.2.10 3.2.2.-]
UMNK88_3558  [KO:K00087] [EC:1.17.1.4]
UMNK88_3559  [KO:K13479] [EC:1.17.1.4]
UMNK88_3560  [KO:K13480]
UMNK88_3566  arcC; carbamate kinase ArcC [KO:K00926] [EC:2.7.2.2]
UMNK88_3575  guaD; guanine deaminase GuaD [KO:K01487] [EC:3.5.4.3]
UMNK88_3651  rdgB; non-canonical purine NTP pyrophosphatase RdgB [KO:K01519] [EC:3.6.1.66]
UMNK88_370  [KO:K00926] [EC:2.7.2.2]
UMNK88_3785  [KO:K03651] [EC:3.1.4.53]
UMNK88_3787  [KO:K01515] [EC:3.6.1.13 3.6.1.-]
UMNK88_4145  [KO:K01839] [EC:5.4.2.7]
UMNK88_4163  [KO:K08312] [EC:3.6.1.-]
UMNK88_4165  [KO:K20881] [EC:3.1.3.-]
UMNK88_440  [KO:K09913] [EC:2.4.2.1 2.4.2.2]
UMNK88_4453  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
UMNK88_4455  [KO:K01139] [EC:2.7.6.5 3.1.7.2]
UMNK88_4474  ade; adenine deaminase [KO:K01486] [EC:3.5.4.2]
UMNK88_4588  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
UMNK88_4617  [KO:K05851] [EC:4.6.1.1]
UMNK88_4645  [KO:K00926] [EC:2.7.2.2]
UMNK88_4846  purD; phosphoribosylamine--glycine ligase PurD [KO:K01945] [EC:6.3.4.13]
UMNK88_4848  purH; bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
UMNK88_49  [KO:K01525] [EC:3.6.1.41]
UMNK88_5116  purA; adenylosuccinate synthetase PurA [KO:K01939] [EC:6.3.4.4]
UMNK88_5160  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase CpdB [KO:K01119] [EC:3.1.4.16 3.1.3.6]
UMNK88_5184  nrdD; anaerobic ribonucleoside-triphosphate reductase NrdD [KO:K21636] [EC:1.1.98.6]
UMNK88_522  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
UMNK88_527  [KO:K00939] [EC:2.7.4.3]
UMNK88_530  [KO:K00892] [EC:2.7.1.73]
UMNK88_5302  deoB; phosphopentomutase DeoB [KO:K01839] [EC:5.4.2.7]
UMNK88_5303  deoD; purine nucleoside phosphorylase DeoD [KO:K03784] [EC:2.4.2.1]
UMNK88_5313  [KO:K01529]
UMNK88_533  [KO:K11751] [EC:3.1.3.5 3.6.1.45]
UMNK88_556  [KO:K01483] [EC:4.3.2.3]
UMNK88_562  allB; allantoinase AllB [KO:K01466] [EC:3.5.2.5]
UMNK88_565  [KO:K14977] [EC:3.5.3.26]
UMNK88_566  allC; allantoate amidohydrolase AllC [KO:K02083] [EC:3.5.3.9]
UMNK88_567  allD; ureidoglycolate dehydrogenase AllD [KO:K00073] [EC:1.1.1.350]
UMNK88_571  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
UMNK88_572  purK; phosphoribosylaminoimidazole carboxylase, ATPase subunit PurK [KO:K01589] [EC:6.3.4.18]
UMNK88_573  purE; phosphoribosylaminoimidazole carboxylase, catalytic subunit PurE [KO:K01588] [EC:5.4.99.18]
UMNK88_710  nagD; UMP phosphatase NagD [KO:K02566] [EC:3.1.3.5]
UMNK88_725  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eun00030  Pentose phosphate pathway
eun00220  Arginine biosynthesis
eun00250  Alanine, aspartate and glutamate metabolism
eun00260  Glycine, serine and threonine metabolism
eun00340  Histidine metabolism
eun00630  Glyoxylate and dicarboxylate metabolism
eun00730  Thiamine metabolism
eun00740  Riboflavin metabolism
eun00790  Folate biosynthesis
KO pathway
ko00230   

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