KEGG   Homo sapiens (human): 1584
Entry
1584              CDS       T01001                                 
Symbol
CYP11B1, CPN1, CYP11B, FHI, P450C11
Name
(RefSeq) cytochrome P450 family 11 subfamily B member 1
  KO
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Module
hsa_M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
hsa_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019  Steroid hormone biosynthesis
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00306  SF-1-mediated transcription
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00338  Steroid hormone biosynthesis, progesterone to cortisol/cortisone
N00339  Steroid hormone biosynthesis, progesterone to aldosterone
Disease
H00216  Congenital adrenal hyperplasia
H00602  Glucocorticoid-remediable aldosteronism (GRA)
H01603  Primary aldosteronism
H01633  High blood pressure
Drug target
Levoketoconazole: D10950<US>
Metyrapone (DG01166): D00410<JP/US> D05019
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1584 (CYP11B1)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    1584 (CYP11B1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1584 (CYP11B1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1584 (CYP11B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     1584 (CYP11B1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP11 family
   1584 (CYP11B1)
SSDB
Motif
Pfam: p450 INT1_R3
Other DBs
NCBI-GeneID: 1584
NCBI-ProteinID: NP_000488
OMIM: 610613
HGNC: 2591
Ensembl: ENSG00000160882
UniProt: P15538 Q8TDD0
Structure
LinkDB
Position
8:complement(142872357..142879825)
AA seq 503 aa
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
NT seq 1512 nt   +upstreamnt  +downstreamnt
atggcactcagggcaaaggcagaggtgtgcatggcagtgccctggctgtccctgcaaagg
gcacaggcactgggcacgagagccgcccgggtccccaggacagtgctgccctttgaagcc
atgccccggcgtccaggcaacaggtggctgaggctgctgcagatctggagggagcagggt
tatgaggacctgcacctggaagtacaccagaccttccaggaactagggcccattttcagg
tacgacttgggaggagcaggcatggtgtgtgtgatgctgccggaggacgtggagaagctg
caacaggtggacagcctgcatccccacaggatgagcctggagccctgggtggcctacaga
caacatcgtgggcacaaatgtggcgtgttcttgctgaatgggcctgaatggcgcttcaac
cgattgcggctgaatccagaagtgctgtcgcccaacgctgtgcagaggttcctcccgatg
gtggatgcagtggccagggacttctcccaggccctgaagaagaaggtgctgcagaacgcc
cgggggagcctgaccctggacgtccagcccagcatcttccactacaccatagaagccagc
aacttggctctttttggagagcggctgggcctggttggccacagccccagttctgccagc
ctgaacttcctccatgccctggaggtcatgttcaaatccaccgtccagctcatgttcatg
cccaggagcctgtctcgctggaccagccccaaggtgtggaaggagcactttgaggcctgg
gactgcatcttccagtacggcgacaactgtatccagaaaatctatcaggaactggccttc
agccgccctcaacagtacaccagcatcgtggcggagctcctgttgaatgcggaactgtcg
ccagatgccatcaaggccaactctatggaactcactgcagggagcgtggacacgacggtg
tttcccttgctgatgacgctctttgagctggctcggaaccccaacgtgcagcaggccctg
cgccaggagagcctggccgccgcagccagcatcagtgaacatccccagaaggcaaccacc
gagctgcccttgctgcgtgcggccctcaaggagaccttgcggctctaccctgtgggtctg
tttctggagcgagtggcgagctcagacttggtgcttcagaactaccacatcccagctggg
acattggtgcgcgtgttcctctactctctgggtcgcaaccccgccttgttcccgaggcct
gagcgctataacccccagcgctggctagacatcaggggctccggcaggaacttctaccac
gtgccctttggctttggcatgcgccagtgccttgggcggcgcctggcagaggcagagatg
ctgctgctgctgcaccatgtgctgaaacacctccaggtggagacactaacccaagaggac
ataaagatggtctacagcttcatattgaggcccagcatgttccccctcctcaccttcaga
gccatcaactaa

KEGG   Homo sapiens (human): 1585
Entry
1585              CDS       T01001                                 
Symbol
CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
Name
(RefSeq) cytochrome P450 family 11 subfamily B member 2
  KO
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04925  Aldosterone synthesis and secretion
Module
hsa_M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Network
nt06019  Steroid hormone biosynthesis
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
  Element
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00338  Steroid hormone biosynthesis, progesterone to cortisol/cortisone
N00339  Steroid hormone biosynthesis, progesterone to aldosterone
Disease
H00258  Aldosterone synthase deficiency
H00602  Glucocorticoid-remediable aldosteronism (GRA)
H01633  High blood pressure
Drug target
Baxdrostat: D12789
Lorundrostat (DG03289): D12773 D12774
Osilodrostat (DG02839): D11061 D11062<JP/US>
Vicadrostat: D13192
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1585 (CYP11B2)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    1585 (CYP11B2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1585 (CYP11B2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     1585 (CYP11B2)
    1.14.15.5  corticosterone 18-monooxygenase
     1585 (CYP11B2)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP11 family
   1585 (CYP11B2)
SSDB
Motif
Pfam: p450 INT1_R3
Other DBs
NCBI-GeneID: 1585
NCBI-ProteinID: NP_000489
OMIM: 124080
HGNC: 2592
Ensembl: ENSG00000179142
UniProt: P19099
Structure
LinkDB
Position
8:complement(142910559..142917843)
AA seq 503 aa
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
NT seq 1512 nt   +upstreamnt  +downstreamnt
atggcactcagggcaaaggcagaggtgtgcgtggcagcgccctggctgtccctgcaaagg
gcacgggcactgggcactagagccgctcgggcccctaggacggtgctgccgtttgaagcc
atgccccagcatccaggcaacaggtggctgaggctgctgcagatctggagggagcagggt
tatgagcacctgcacctggagatgcaccagaccttccaggagctggggcccattttcagg
tacaacttgggaggaccacgcatggtgtgtgtgatgctgccggaggatgtggagaagctg
caacaggtggacagcctgcatccctgcaggatgatcctggagccctgggtggcctacaga
caacatcgtgggcacaaatgtggcgtgttcttgttgaatgggcctgaatggcgcttcaac
cgattgcggctgaacccagatgtgctgtcgcccaaggccgtgcagaggttcctcccgatg
gtggatgcagtggccagggacttctcccaggccctgaagaagaaggtgctgcagaacgcc
cgggggagcctgaccctggacgtccagcccagcatcttccactacaccatagaagccagc
aacttagctctttttggagagcggctgggcctggttggccacagccccagttctgccagc
ctgaacttcctccatgccctggaggtcatgttcaaatccaccgtccagctcatgttcatg
cccaggagcctgtctcgctggatcagccccaaggtgtggaaggagcactttgaggcctgg
gactgcatcttccagtacggtgacaactgtatccagaaaatctaccaggaactggccttc
aaccgccctcaacactacacaggcatcgtggcggagctcctgttgaaggcggaactgtca
ctagaagccatcaaggccaactctatggaactcactgcagggagcgtggacacgacagcg
tttcccttgctgatgacgctctttgagctggctcggaaccccgacgtgcagcagatcctg
cgccaggagagcctggccgccgcagccagcatcagtgaacatccccagaaggcaaccacc
gagctgcccttgctgcgggcggccctcaaggagaccttgcggctctaccctgtgggtctg
tttttggagcgagtggtgagctcagacttggtgcttcagaactaccacatcccagctggg
acattggtacaggttttcctctactcgctgggtcgcaatgccgccttgttcccgaggcct
gagcggtataatccccagcgctggctagacatcaggggctccggcaggaacttccaccac
gtgccctttggctttggcatgcgccagtgcctcgggcggcgcctggcagaggcagagatg
ctgctgctgctgcaccacgtgctgaagcacttcctggtggagacactaactcaagaggac
ataaagatggtctacagcttcatattgaggcctggcacgtcccccctcctcactttcaga
gcgattaactag

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