KEGG    Network variation - Parkinson disease
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ENTRYnt06463
NameParkinson disease
CategoryDisease view; Neurodegenerative disease
Pathwayhsa05012 Parkinson disease
DiseaseH00057 Parkinson disease
Display drug-target relation   disease type
Calcium signaling
N00953    Glutamate→GRM1→GNAQ→PLCB→IP3→ITPR→Ca2+→PKC⊣TRPC3→Ca2+
N01032        PRKN*→PLCG1→IP3→ITPR→Ca2+
N00967    Ca2+(extracellular..−VGCC→Ca2+−MCU→Ca2+(mito)−MPTP→CYCS=APAF1→CASP9→(CASP3,CASP7)
N01031    Ca2+(extracellular..−SNCA*→Ca2+−MCU→Ca2+(mito)−MPTP→CYCS=APAF1→CASP9→CASP3
 
Ubiquitin-proteasome system
N01019    UBCH7/8=PRKN⊣alphaSp22
N01020    UBCH7/8⌿PRKN*⌿alphaSp22
N01021    UBCH7/8=PRKN⊣PAELR
N01022    UBCH7/8⌿PRKN*⌿PAELR
N01023    UBCH7/8=PRKN⊣CDCREL1
N01024    UBCH7/8⌿PRKN*⌿CDCREL1
N01025    UBCH7/8=PRKN⊣SYPH1
N01026    UBCH7/8⌿PRKN*⌿SYPH1
N01029    (Protein+UB)−26S→Peptide
N01030    SNCA*⊣26S
N01027    UB(chain)−UCHL1→UB(free)
N01028    UB(chain)⌿UCHL1*⌿UB(free)
 
Unfolded protein response (UPR) signaling
N01009        EIF2AK3→EIF2S1→ATF4⇒DDIT3
N01035    SNCA*⊣BIP⊣EIF2AK3→EIF2S1→ATF4⇒DDIT3
N01011        ERN1→XBP1⇒DDIT3
N01034    SNCA*⊣BIP⊣ERN1→XBP1
N01015        ATF6⇒(DDIT3,XBP1,HSPA5)
N01033    SNCA*⊣BIP⊣ATF6⇒DDIT3
 
Mitophagy
N01052    PINK1→PRKN⊣MFN1/2
N01053    PINK1*⌿PRKN⌿MFN1/2
N01054      PRKN*⌿MFN1/2
 
Apoptosis
N00098    (PMAIP1,BBC3,BAD,B..⊣(BCL2,BCL2L1)⊣(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
N01051    DJ1*⌿BCL2L1⌿BAX
N01050    PINK1*⌿PRKN⌿BAX→CYCS=APAF1→CASP9→CASP3
N01049      PRKN*⌿BAX→CYCS=APAF1→CASP9→CASP3
N01048      PINK1*⌿(HTRA2,TRAP1)⌿CYCS=APAF1→CASP9→CASP3
N01047        LRRK2*→CYCS=APAF1→CASP9→CASP3
N01056      FASLG→FAS→(DAXX+ASK1)→JNK
N01057        DJ1*⌿(DAXX+ASK1)→JNK
N01417    PQ→ROS⊣TRX1⊣ASK1→JNK
 
Dopamine metabolism
N01530    Tyr+BH4−TH→L-Dopa−DDC→Dopamine−MAO→DOPAL
N01037    SNCA*⌿TH→L-Dopa
N01039            PRKN*⌿MAO→DOPAL
N01040    Dopamine−VMAT→Dopamine(SV)
N01041    SNCA*⊣VMAT2
 
Oxidative phosphorylation
N00995    NADH−CxI→Q
N01042    SNCA*⊣CxI→Q
N01043    PINK1*⊣CxI→Q
N01044    MPP+⊣CxI→Q
N01045    Rotenone⊣CxI→Q
N00988    Succinate−CxII→QH2
N01402    Mn2+⊣CxII→QH2
N00990    QH2−CxIII→CytC
N01046    Maneb⊣CxIII→CytC
 
Microtubule-based transport
N00976      (DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
N01055    SNCA*⊣(KIF5+KLC)⌿(TUBA+TUBB)
 
Transcription
N01058    DJ1*⌿TP53⇒DUSP1
N00243    (O2-,HO2,H2O2,OH,A..⊣KEAP1⊣NRF2⇒(HMOX1,NQO1,GST,TX..
N01059      DJ1*⌿NRF2⌿TRX1