KEGG   Homo sapiens (human): 5424
Entry
5424              CDS       T01001                                 
Symbol
POLD1, CDC2, CRCS10, IMD120, MDPL, POLD
Name
(RefSeq) DNA polymerase delta 1, catalytic subunit
  KO
K02327  DNA polymerase delta subunit 1 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01472  Okazaki fragment maturation
Disease
H00020  Colorectal cancer
H00093  Combined immunodeficiency
H01623  MDPL syndrome
H02568  Polymerase proofreading-associated polyposis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5424 (POLD1)
   03410 Base excision repair
    5424 (POLD1)
   03420 Nucleotide excision repair
    5424 (POLD1)
   03430 Mismatch repair
    5424 (POLD1)
   03440 Homologous recombination
    5424 (POLD1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5424 (POLD1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5424 (POLD1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5424 (POLD1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    5424 (POLD1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      5424 (POLD1)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     5424 (POLD1)
SSDB
Motif
Pfam: DNA_pol_B DNA_pol_B_exo1 zf-C4pol POL3_N REV3_N DNA_pol_B_2
Other DBs
NCBI-GeneID: 5424
NCBI-ProteinID: NP_001243778
OMIM: 174761
HGNC: 9175
Ensembl: ENSG00000062822
UniProt: P28340
Structure
LinkDB
Position
19:50384323..50418018
AA seq 1107 aa
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
MRKKVRKDLEDQEQLLRRFGPPGPEAW
NT seq 3324 nt   +upstreamnt  +downstreamnt
atggatggcaagcggcggccaggcccagggcccggggtgcccccaaagcgggcccgtggg
ggcctctgggatgatgatgatgcacctcggccatcccaattcgaggaggacctggcactg
atggaggagatggaggcagaacacaggctgcaggagcaggaggaggaggagctgcagtca
gtcctggagggggttgcagacgggcaggtcccaccatcagccatagatcctcgctggctt
cggcccacaccaccagcgctggacccccagacagagcccctcatcttccaacagttggag
attgaccattatgtgggcccagcgcagcctgtgcctggggggcccccaccatcccgcggc
tccgtgcctgtgctccgcgccttcggggtcaccgatgaggggttctctgtctgctgccac
atccacggcttcgctccctacttctacaccccagcgccccctggtttcgggcccgagcac
atgggtgacctgcaacgggagctgaacttggccatcagccgggacagtcgcggggggagg
gagctgactgggccggccgtgctggctgtggaactgtgctcccgagagagcatgtttggg
taccacgggcacggcccctccccgttcctgcgcatcaccgtggcgctgccgcgcctcgtg
gccccggcccgccgtctcctggaacagggcatccgtgtggcaggcctgggcacgcccagc
ttcgcgccctacgaggccaacgtcgactttgagatccggttcatggtggacacggacatc
gtcggctgcaactggctggagctcccagctgggaaatacgccctgaggctgaaggagaag
gctacgcagtgccagctggaggcggacgtgctgtggtctgacgtggtcagtcacccaccg
gaagggccatggcagcgcattgcgcccttgcgcgtgctcagcttcgatatcgagtgcgcc
ggccgcaaaggcatcttccctgagcctgagcgggaccctgtcatccagatctgctcgctg
ggcctgcgctggggggagccggagcccttcctacgcctggcgctcaccctgcggccctgt
gcccccatcctgggtgccaaggtgcagagctacgagaaggaggaggacctgctgcaggcc
tggtccaccttcatccgtatcatggaccccgacgtgatcaccggttacaacatccagaac
ttcgaccttccgtacctcatctctcgggcccagaccctcaaggtacaaacattccctttc
ctgggccgtgtggccggcctttgctccaacatccgggactcttcattccagtccaagcag
acgggccggcgggacaccaaggttgtcagcatggtgggccgcgtgcagatggacatgctg
caggtgctgctgcgggagtacaagctccgctcctacacgctcaatgccgtgagcttccac
ttcctgggcgagcagaaggaggacgtgcagcacagcatcatcaccgacctgcagaatggg
aacgaccagacccgccgccgcctggctgtgtactgcctgaaggatgcctacctgccactg
cggctgctggagcggctcatggtgctggtgaacgccgtggagatggcgagggtcactggc
gtgcccctcagctacctgctcagtcgtggccagcaggtcaaggtcgtatcccagctgttg
cggcaggccatgcacgaggggctgctgatgcccgtggtgaagtcagagggcggcgaggac
tacacgggagccactgtcatcgagcccctcaaagggtactacgacgtccccatcgccacc
ctggacttctcctcgctgtacccgtccatcatgatggcccacaacctgtgttacaccacg
ctccttcggcccgggactgcacagaaactgggcctgactgaggatcagttcatcaggacc
cccaccggggacgagtttgtgaagacctcagtgcggaaggggctgctgccccagatcctg
gagaacctgctcagtgcccggaagagggccaaggccgagctggccaaggagacagacccc
ctccggcgccaggtcctggatggacggcagctggcgctgaaggtgagcgccaactccgta
tacggcttcactggcgcccaggtgggcaagttgccgtgcctggagatctcacagagcgtc
acggggttcggacgtcagatgatcgagaaaaccaagcagctggtggagtctaagtacaca
gtggagaatggctacagcaccagtgccaaggtggtgtatggtgacactgactccgtcatg
tgccgattcggcgtgtcctcggtggctgaggcgatggccctggggcgggaggccgcggac
tgggtgtcaggtcacttcccgtcgcccatccggctggagtttgagaaggtctacttccca
tacctgcttatcagcaagaagcgctacgcgggcctgctcttctcctcccggcccgacgcc
cacgaccgcatggactgcaagggcctggaggccgtgcgcagggacaactgccccctcgtg
gccaacctggtcactgcctcactgcgccgcctgctcatcgaccgagaccctgagggcgcg
gtggctcacgcacaggacgtcatctcggacctgctgtgcaaccgcatcgatatctcccag
ctggtcatcaccaaggagctgacccgcgcggcctccgactatgccggcaagcaggcccac
gtggagctggccgagaggatgaggaagcgggaccccgggagtgcgcccagcctgggcgac
cgcgtcccctacgtgatcatcagtgccgccaagggtgtggccgcctacatgaagtcggag
gacccgctgttcgtgctggagcacagcctgcccattgacacgcagtactacctggagcag
cagctggccaagcccctcctgcgcatcttcgagcccatcctgggcgagggccgtgccgag
gctgtgctactgcggggggaccacacgcgctgcaagacggtgctcacgggcaaggtgggc
ggcctcctggccttcgccaaacgccgcaactgctgcattggctgccgcacagtgctcagc
caccagggagccgtgtgtgagttctgccagccccgggagtctgagctgtatcagaaggag
gtatcccatctgaatgccctggaggagcgcttctcgcgcctctggacgcagtgccagcgc
tgccagggcagcctgcacgaggacgtcatctgcaccagccgggactgccccatcttctac
atgcgcaagaaggtgcggaaggacctggaagaccaggagcagctcctgcggcgcttcgga
ccccctggacctgaggcctggtga

KEGG   Homo sapiens (human): 5425
Entry
5425              CDS       T01001                                 
Symbol
POLD2
Name
(RefSeq) DNA polymerase delta 2, accessory subunit
  KO
K02328  DNA polymerase delta subunit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01472  Okazaki fragment maturation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5425 (POLD2)
   03410 Base excision repair
    5425 (POLD2)
   03420 Nucleotide excision repair
    5425 (POLD2)
   03430 Mismatch repair
    5425 (POLD2)
   03440 Homologous recombination
    5425 (POLD2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5425 (POLD2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5425 (POLD2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    5425 (POLD2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      5425 (POLD2)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     5425 (POLD2)
SSDB
Motif
Pfam: DNA_pol_E_B DNA_pol_D_N
Other DBs
NCBI-GeneID: 5425
NCBI-ProteinID: NP_001120690
OMIM: 600815
HGNC: 9176
Ensembl: ENSG00000106628
UniProt: P49005
Structure
LinkDB
Position
7:complement(44114680..44124325)
AA seq 469 aa
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQ
MRPFLENRAQQHWGSGVGVKKLCELQPEEKCCVVGTLFKAMPLQPSILREVSEEHNLLPQ
PPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVRDDGKFLVEDYCFAD
LAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSR
VILAGNLLSHSTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFD
PTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMED
HLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFGSKIIRGPED
QTVLLVTVPDFSATQTACLVNLRSLACQPISFSGFGAEDDDLGGLGLGP
NT seq 1410 nt   +upstreamnt  +downstreamnt
atgttttctgagcaggctgcccagagggcccacactctactgtccccaccatcagccaac
aatgccacctttgcccgggtgccagtggcaacctacaccaactcctcacaacccttccgg
ctaggagagcgcagctttagccggcagtatgcccacatttatgccacccgcctcatccaa
atgagacccttcctggagaaccgggcccagcagcactggggcagtggagtgggagtgaag
aagctgtgtgaactgcagcctgaggagaagtgctgtgtggtgggcactctgttcaaggcc
atgccgctgcagccctccatcctgcgggaggtcagcgaggagcacaacctgctcccccag
cctcctcggagtaaatacatacacccagatgacgagctggtcttggaagatgaactgcag
cgtatcaaactaaaaggcaccattgacgtgtcaaagctggttacggggactgtcctggct
gtgtttggctccgtgagagacgacgggaagtttctggtggaggactattgctttgctgac
cttgctccccagaagcccgcacccccacttgacacagataggtttgtgctactggtgtcc
ggcctgggcctgggtggcggtggaggcgagagcctgctgggcacccagctgctggtggat
gtggtgacggggcagcttggggacgaaggggagcagtgcagcgccgcccacgtctcccgg
gttatcctcgctggcaacctcctcagccacagcacccagagcagggattctatcaataag
gccaaatacctcaccaagaaaacccaggcagccagcgtggaggctgttaagatgctggat
gagatcctcctgcagctgagcgcctcagtgcccgtggacgtgatgccaggcgagtttgat
cccaccaattacacgctcccccagcagcccctccacccctgcatgttcccgctggccact
gcctactccacgctccagctggtcaccaacccctaccaggccaccattgatggagtcaga
tttttggggacatcaggacagaacgtgagtgacattttccgatacagcagcatggaggat
cacttggagatcctggagtggaccctgcgggtccgtcacatcagccccacagcccctgac
actctaggttgttaccccttctacaaaactgacccgttcatcttcccagagtgcccgcat
gtctacttttgtggcaacacccccagctttggctccaaaatcatccgaggtcctgaggac
cagacagtgctgttggtgactgtccctgacttcagtgccacgcagaccgcctgccttgtg
aacctgcgcagcctggcctgccagcccatcagcttctcgggcttcggggcagaggacgat
gacctgggaggcctggggctgggcccctga

KEGG   Homo sapiens (human): 10714
Entry
10714             CDS       T01001                                 
Symbol
POLD3, IMD122, P66, P68, PPP1R128
Name
(RefSeq) DNA polymerase delta 3, accessory subunit
  KO
K03504  DNA polymerase delta subunit 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01450  Break induced replication
N01452  Homologous recombination
N01472  Okazaki fragment maturation
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    10714 (POLD3)
   03410 Base excision repair
    10714 (POLD3)
   03420 Nucleotide excision repair
    10714 (POLD3)
   03430 Mismatch repair
    10714 (POLD3)
   03440 Homologous recombination
    10714 (POLD3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    10714 (POLD3)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    10714 (POLD3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10714 (POLD3)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     10714 (POLD3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    10714 (POLD3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      10714 (POLD3)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     10714 (POLD3)
SSDB
Motif
Pfam: CDC27
Other DBs
NCBI-GeneID: 10714
NCBI-ProteinID: NP_006582
OMIM: 611415
HGNC: 20932
Ensembl: ENSG00000077514
UniProt: Q15054
Structure
LinkDB
Position
11:74592582..74669341
AA seq 466 aa
MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT
YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD
ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG
KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR
GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK
TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggcggaccagctttatctggaaaatatagacgagttcgtcacggaccaaaacaagatc
gtgacatacaaatggctgagctatacactaggggttcatgttaaccaggccaaacagatg
ctgtatgattatgttgaaaggaaacgaaaagaaaattcaggagcccaactgcatgttacc
tacttggtgtctggcagtctcattcagaatggacattcctgccacaaggttgcagtagtg
agagaagataaattggaagcagtgaagtccaagctagctgtgactgccagcatccatgtg
tacagcatccagaaagccatgctaaaggacagtgggcctctgttcaatactgactatgac
atccttaaaagcaacttgcagaactgcagcaaatttagtgctatacaatgtgcagctgcc
gtccctagagctcctgctgaatcctcttcgtcttccaaaaagtttgagcagtcacatctt
cacatgtcaagtgagacacaagccaacaatgagctgaccaccaatggtcatggcccacct
gcatccaagcaggtttcccagcagcccaaaggaattatgggaatgtttgcctccaaagct
gctgctaaaacccaagaaaccaacaaggaaacgaaaacagaggctaaagaagtaacaaat
gcatctgcagcaggcaacaaggcaccagggaaagggaatatgatgagcaacttttttgga
aaagctgctatgaataaatttaaagtcaatttggactcagaacaagcagtgaaagaagaa
aaaatagtggagcagcctacagtgtctgtcacggaaccaaagctggcaactcctgcaggc
ctgaaaaaatccagcaaaaaagcagagcctgttaaggtgctgcagaaggaaaaaaaaagg
gggaagcgagtagcattatctgatgatgagacaaaggaaactgaaaacatgaggaaaaag
aggagaagaatcaaacttcctgaatctgatagcagtgaagatgaagtctttccagactct
cctggggcttatgaagctgagtcaccatccccacctcctcctccgtctccacctcttgaa
ccagtgccaaagactgagcctgaacctccttctgtcaagagctcaagtggagaaaacaaa
agaaaacgaaaacgcgtactaaaatctaaaacttacctggatggggaaggctgcatagtg
actgaaaaagtctacgagagtgaatcctgcacagatagtgaagaggagcttaacatgaag
acatcctcagtacacagaccccctgccatgactgtgaaaaaagaacccagagaggaacga
aagggccccaagaaagggactgctgctctgggcaaagccaacagacaggtgtccattact
ggcttcttccagaggaaataa

KEGG   Homo sapiens (human): 57804
Entry
57804             CDS       T01001                                 
Symbol
POLD4, POLDS, p12
Name
(RefSeq) DNA polymerase delta 4, accessory subunit
  KO
K03505  DNA polymerase delta subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01472  Okazaki fragment maturation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    57804 (POLD4)
   03410 Base excision repair
    57804 (POLD4)
   03420 Nucleotide excision repair
    57804 (POLD4)
   03430 Mismatch repair
    57804 (POLD4)
   03440 Homologous recombination
    57804 (POLD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    57804 (POLD4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    57804 (POLD4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    57804 (POLD4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      57804 (POLD4)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     57804 (POLD4)
SSDB
Motif
Pfam: DNA_pol_delta_4
Other DBs
NCBI-GeneID: 57804
NCBI-ProteinID: NP_066996
OMIM: 611525
HGNC: 14106
Ensembl: ENSG00000175482
UniProt: Q9HCU8 Q6NSD7
Structure
LinkDB
Position
11:complement(67350765..67353596)
AA seq 107 aa
MGRKRLITDSYPVVKRREGPAGHSKGELAPELGEEPQPRDEEEAELELLRQFDLAWQYGP
CTGITRLQRWCRAKQMGLEPPPEVWQVLKTHPGDPRFQCSLWHLYPL
NT seq 324 nt   +upstreamnt  +downstreamnt
atgggccggaagcggctcatcactgattcctacccggttgtgaagaggagggaggggccc
gctgggcacagcaagggggagctggcacccgagctaggggaggagccccagccccgcgac
gaggaggaagcggagctggagctgctgaggcagtttgacctggcctggcagtacgggccc
tgcaccgggatcacacggctgcagcgctggtgtcgggccaagcagatgggcttggagcct
cccccagaggtgtggcaggtgctgaagacccaccccggagacccccgcttccagtgcagt
ctctggcatctctatcccctatga

KEGG   Homo sapiens (human): 5426
Entry
5426              CDS       T01001                                 
Symbol
POLE, CRCS12, FILS, IMAGEI, POLE1
Name
(RefSeq) DNA polymerase epsilon, catalytic subunit
  KO
K02324  DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Disease
H00020  Colorectal cancer
H02369  IMAGE-I syndrome
H02370  FILS syndrome
H02568  Polymerase proofreading-associated polyposis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5426 (POLE)
   03410 Base excision repair
    5426 (POLE)
   03420 Nucleotide excision repair
    5426 (POLE)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5426 (POLE)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5426 (POLE)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5426 (POLE)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5426 (POLE)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5426 (POLE)
SSDB
Motif
Pfam: DUF1744 POL2_thumb DNA_pol_B_exo1 zf_DPOE_2 zf-DPOE DNA_pol_B DNA_pol_B_exo2 RNase_H_2 APP_N Translat_reg
Other DBs
NCBI-GeneID: 5426
NCBI-ProteinID: NP_006222
OMIM: 174762
HGNC: 9177
Ensembl: ENSG00000177084
UniProt: Q07864
Structure
LinkDB
Position
12:complement(132623762..132687342)
AA seq 2286 aa
MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKT
GWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFL
SKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ
DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHV
AHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI
DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV
TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVG
SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA
LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV
GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVC
DEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPG
ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEK
RRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS
AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGA
NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIM
VKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN
EDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK
AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII
SRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSA
IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEA
SEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPA
LGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR
RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGAS
YRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVH
LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALF
GIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETD
LKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYG
VLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH
NHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTIL
QSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVV
GWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLG
SSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPS
NYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNW
NILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGA
VGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNP
ALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRS
CNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLV
CLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQK
NPQLGH
NT seq 6861 nt   +upstreamnt  +downstreamnt
atgtctctgaggagcggcgggcggcggcgcgcggacccaggcgcggatggcgaggccagc
agggatgatggcgccacttcctcagtttcggcactcaagcgcctggaacggagtcagtgg
acggataagatggatttgcggtttggttttgagcggctgaaggagcctggtgagaagaca
ggctggctcattaacatgcatcctaccgagattttagatgaagataagcgcttaggcagt
gcagtggattactactttattcaagatgacggaagcagatttaaggtggctttgccctat
aaaccgtatttctacattgcgaccagaaagggttgtgagcgagaagtttcatcttttctc
tccaagaagtttcagggcaaaattgcaaaagtggagactgtccccaaagaggatctggac
ttgccaaatcacttggtgggtttgaagcgaaattacatcaggctgtccttccacactgtg
gaggatcttgtcaaagtgaggaaggagatctcccctgccgtgaagaagaacagggagcag
gatcacgccagcgacgcgtacacagctctgctttccagtgttctgcagaggggcggtgtc
attactgatgaagaggaaacctctaagaagatagctgaccagttggacaacattgtggac
atgcgcgagtacgatgttccctaccacatccgcctctccattgacctgaagatccacgtg
gctcattggtacaatgtcagataccgaggaaatgcttttccggtagaaatcacccgccga
gatgaccttgttgaacgacctgaccctgtggttttggcatttgacattgagacgaccaaa
ctgcccctcaagtttcctgatgctgagacagaccagattatgatgatttcctacatgatc
gatggccagggctacctcatcaccaacagggagattgtttcagaagatattgaagatttt
gagttcacccccaagccagaatatgaaggccccttttgtgtcttcaatgaacccgatgag
gctcatctgatccaaaggtggtttgaacacgtccaggagaccaaacccaccatcatggtc
acctacaacggggacttttttgactggccatttgtggaggcccgggcagcagtccacggt
ctgagcatgcagcaggagataggcttccagaaggacagccagggggagtacaaggcgccc
cagtgcatccacatggactgcctcaggtgggtgaagagggacagttaccttcctgtgggc
agtcataatctcaaggcggccgccaaggccaagctaggctatgatcccgtggagctagac
ccggaggacatgtgccggatggccacggagcagccccagactctggccacgtattctgtg
tcagatgctgtcgccacttactacctgtacatgaagtacgtccacccattcatctttgct
ctgtgcaccattattcccatggagcccgacgaggtgctgcggaagggctctggcactctg
tgtgaggccttgctgatggtgcaggccttccacgccaacatcatcttccccaacaagcaa
gagcaggagttcaataagctgacggacgacggacacgtgctggactctgagacctacgtc
gggggccacgtggaggccctcgagtctggggttttccgcagcgatatcccttgccggttt
aggatgaatcctgccgcctttgacttcctgctgcagcgggttgagaagaccttgcgccac
gcccttgaggaagaggagaaagtgcctgtggagcaagtcaccaactttgaagaggtgtgt
gatgagattaagagcaagcttgcctccctgaaggacgttcccagccgcatcgagtgtcca
ctcatctaccacctggacgtgggggccatgtaccccaacatcatcctgaccaaccgcctg
cagccctctgccatggtggacgaagccacctgtgctgcctgtgacttcaataagcctgga
gcaaactgccagcggaagatggcctggcagtggaggggcgagttcatgccagccagtcgc
agcgaataccatcggatccagcaccagctggagtcagagaagttcccccccttgttccca
gaggggccagctcgggcctttcatgaactgtcccgcgaggaacaggcgaaatacgagaag
agaaggctggcggattactgccggaaagcctacaagaagatccacatcaccaaggtggaa
gagcgtctcaccaccatctgccagcgggaaaactccttctacgtggacaccgtgcgtgcc
ttccgggacaggcgttacgagttcaaagggctccacaaggtgtggaaaaagaagctctcg
gcggccgtggaggtgggcgacgcggctgaggtgaagcgctgcaagaacatggaggtgctg
tatgactcgctgcagctggcccacaagtgcatcctgaactccttctatggctatgtcatg
cgcaagggggctcgctggtactccatggagatggctggcatcgtctgcttcacaggggcc
aacatcatcacccaggcacgggagctgatcgagcagattgggaggcccttagagctggac
acagatggtatatggtgcgtcctgcccaacagcttcccagaaaattttgtcttcaagacg
accaatgtgaagaagcccaaagtgaccatctcctacccaggcgccatgttgaacatcatg
gtcaaggaaggcttcaccaatgaccagtaccaggagctggctgagccgtcctcactcacc
tacgtcacccgctcagagaacagcatcttttttgaggttgatgggccctaccttgccatg
attcttccagcctccaaggaagaaggcaagaaattgaagaagaggtatgctgtgttcaat
gaagacggttctctggctgagctcaagggctttgaggtcaaacgccgcggggaactgcag
ctgattaagatcttccaatcctcggtgtttgaggccttcctcaagggcagcacgctggaa
gaggtgtatggctctgtagccaaggtggctgactactggctggacgtgctgtacagcaag
gcagccaacatgcctgactctgagctattcgagctcatctctgagaaccgttccatgtct
cggaagctggaagattacggggagcagaagtctacgtccatcagcacagcaaagcgcctg
gccgagttcctgggagaccagatggtcaaggatgcagggctgagttgccgctacatcatc
tcccgcaagcccgagggctcccctgtcacggagagggccatcccacttgccattttccaa
gcagagcccacggtgaggaagcactttctccggaaatggctcaagagctcttcccttcaa
gactttgatattcgagcaattctggattgggactactacattgagcggctgggaagcgcc
atccagaagatcatcaccatccctgcggccctgcagcaggtaaagaacccagtgccacgt
gtcaaacaccccgactggctgcacaaaaaactgctggagaagaatgatgtctacaagcag
aagaagatcagtgagctcttcaccctggagggcaggagacaggtcacgatggccgaggcc
tcagaagacagtccgaggccaagtgctcctgacatggaggacttcggcctcgtaaagctg
cctcacccagcagcccctgtcactgtgaagaggaagcgagttctttgggagagccaggag
gagtcccaggacctcacgccgactgtgccctggcaggaaatcttggggcagcctcccgcc
ctgggaaccagccaggaggaatggcttgtctggctccggttccacaagaagaagtggcag
ctgcaggcccggcagcgcctcgcccgcaggaagaggcagcgtctggagtcggcagagggt
gtgctcaggcccggggccatccgggatggtcctgccacggggctggggagcttcttgcga
agaactgcccgcagcatcctggaccttccgtggcagattgtgcagatcagcgagaccagc
caggccggcctgttcaggctgtgggcgctcgttggcagtgacttgcactgcatcaggctg
agcatcccccgtgtgttctacgtgaaccagcgagtcgctaaagcggaggagggtgcttcg
tatcgcaaggtaaatcgggtccttcctcgctccaacatggtctacaatctctatgagtat
tcagtgccagaggacatgtaccaggaacacatcaacgagatcaacgctgagctgtcagcg
ccagacatcgagggcgtatatgagactcaggttccgttactgttccgggccctggtgcac
ctgggctgtgtgtgtgtggtcaataaacagctggtgaggcacctttcaggctgggaagca
gagacctttgctcttgagcacctggagatgcgctctctggcccagttcagctacctggaa
ccagggagtatccgccatatctacctgtaccaccacgcacaggcccacaaagcgctcttc
gggatcttcatcccctcacagcgcagggcatccgtctttgtgctggacactgtgcgcagc
aaccagatgcccagccttggcgccctgtactcagcagagcacggcctcctcctggagaag
gtgggccctgagctcctgccaccccccaaacacaccttcgaagttcgggcagaaactgac
ctgaagaccatctgcagagccatccagcgattcctgctcgcctacaaggaggagcgccgg
gggcccacactcatcgctgttcagtccagctgggagctgaagaggctggccagtgaaatt
cctgtcttggaggaattcccactggtgcctatctgtgtggctgacaagatcaactatggg
gtcctggactggcagcgccatggagcccggcgcatgatccgtcactacctcaacctggac
acctgcctgtcgcaggccttcgagatgagcaggtactttcacattcccattgggaaccta
ccagaggacatctccacattcggctccgacctcttctttgcccgccacctccagcgccac
aaccacctgctctggctgtcccctacagcccgccctgacctgggtggaaaggaggctgat
gacaactgtcttgtcatggagttcgatgaccaagccactgttgagatcaacagttcaggc
tgttactccacagtgtgtgtggagctggaccttcagaacctggccgtcaacaccattctc
cagtctcaccatgtcaacgacatggagggggccgacagcatggggatcagcttcgacgtg
atccagcaggcctccctggaggacatgatcacgggtggtcaggctgccagtgccccggcc
agctacgatgagacagccctgtgctctaacaccttcaggatcctgaagagcatggtcgtg
ggctgggtgaaggagatcacccagtaccacaacatctatgcagacaaccaggtgatgcac
ttctaccgctggcttcggtcgccatcctctctgcttcatgaccctgccctgcaccgcaca
ctccacaacatgatgaagaagctcttcctgcagctcatcgctgagttcaagcgcctgggg
tcatcagtcatctacgccaacttcaaccgcatcatcctctgtacaaagaagcgccgtgtg
gaagatgccatcgcttacgtggagtacatcaccagcagcatccattcaaaggagaccttc
cattctctgacaatttctttctctcgatgctgggaatttcttctctggatggatccatct
aactatggcggaatcaaaggaaaagtttcatctcgtattcactgtggactgcaagactcc
cagaaagcagggggagcagaggatgagcaggaaaatgaggacgatgaggaggaaagagat
ggggaggaggaggaagaggcggaggaatccaacgtggaggatttactggaaaacaactgg
aacattttgcagtttttgccacaggcagcctcctgccagaactacttcctcatgattgtt
tcagcgtacatcgtggccgtgtaccactgcatgaaggacgggctgaggcgcagtgctcca
gggagcacccccgtgaggaggaggggggccagccagctctcccaggaggccgagggggcg
gtcggagcccttcccggaatgatcaccttctctcaggattatgtcgcaaatgagctcact
cagagcttcttcaccatcactcagaagattcagaagaaagtcacaggctctcggaactcc
actgagctctcagagatgtttcctgtcctccccggttcccacttgctgctcaataaccct
gccctggagttcatcaaatacgtgtgcaaggtgctgtccctggacaccaacatcacaaac
caggtgaataagctgaaccgagacctgcttcgcctggtggatgtcggcgagttctccgag
gaggcccagttccgagacccctgccgctcctacgtgcttcctgaggtcatctgccgcagc
tgtaacttctgccgcgacctggacctgtgtaaagactcttccttctcagaggatggggcg
gtcctgcctcagtggctctgctccaactgtcaggcgccctacgactcctctgccatcgag
atgacgctggtggaagttctacagaagaagctgatggccttcaccctgcaggacctggtc
tgcctgaagtgccgcggggtgaaggagaccagcatgcctgtgtactgcagctgcgcggga
gacttcgccctcaccatccacacccaggtcttcatggaacagatcggaatattccggaac
attgcccagcactacggcatgtcgtacctcctggagaccctggagtggctgctgcagaag
aacccacagctgggccattag

KEGG   Homo sapiens (human): 5427
Entry
5427              CDS       T01001                                 
Symbol
POLE2, DPE2
Name
(RefSeq) DNA polymerase epsilon 2, accessory subunit
  KO
K02325  DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5427 (POLE2)
   03410 Base excision repair
    5427 (POLE2)
   03420 Nucleotide excision repair
    5427 (POLE2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5427 (POLE2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5427 (POLE2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5427 (POLE2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5427 (POLE2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5427 (POLE2)
SSDB
Motif
Pfam: DNA_pol_E_B Dpoe2NT DUF3689
Other DBs
NCBI-GeneID: 5427
NCBI-ProteinID: NP_002683
OMIM: 602670
HGNC: 9178
Ensembl: ENSG00000100479
UniProt: P56282
Structure
LinkDB
Position
14:complement(49643555..49688214)
AA seq 527 aa
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSN
MIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLF
GTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGD
AIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAF
GFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEV
LEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSR
FVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLV
NKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVI
ADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
NT seq 1584 nt   +upstreamnt  +downstreamnt
atggcgccggagcggctgcggagccgggcgctctccgccttcaagttgcggggcttgctg
ctccgtggtgaagctattaagtacctcacagaagctcttcagtctatcagtgaattagag
cttgaagataaactggaaaagataattaatgcagttgagaagcaacccttgtcatcaaac
atgattgaacgatctgtggtggaagcagcagtccaggaatgcagtcagtctgttgatgaa
actatagagcacgttttcaatatcataggagcatttgatattccacgctttgtgtacaat
tcagaaagaaaaaaatttcttcctctgttaatgaccaaccaccctgcaccaaatttattt
ggaacaccaagagataaagcagagatgtttcgtgagcgatataccattttgcaccagagg
acccacaggcatgaattatttactcctccggtgataggttctcaccctgatgaaagcgga
agcaaattccagcttaaaacaatagaaaccttattgggtagtacaaccaaaatcggagat
gcgattgttcttggaatgataacgcagttaaaagagggaaaattttttctggaagatcct
actggaacagtccaactagaccttagtaaagctcagttccatagtggtttatacacagag
gcatgctttgtcttagcagaaggttggtttgaagatcaagtgtttcatgtcaatgccttt
ggatttccacccactgagccctctagtactactagggcatactatggaaatattaatttt
tttggaggtccttctaatacatctgtgaagacttctgcaaaactaaaacagctagaagag
gagaataaagatgctatgtttgtgtttttatctgatgtttggttggaccaggtggaagta
ttggaaaaacttcgcataatgtttgctggttattcaccagcacctccaacctgctttatt
ctgtgtggtaatttttcatctgcaccatatggaaaaaatcaagttcaagctttgaaagat
tccctaaaaactttggcagatataatatgtgaatacccagatattcaccaaagtagtcgt
tttgtgtttgtacctggtccagaggatcctggatttggttccatcttaccaaggccacca
cttgctgaaagcatcactaatgaattcagacaaagggtaccattttcagtttttactact
aatccttgcagaattcagtactgtacacaggaaattactgtcttccgtgaagacttagta
aataaaatgtgcagaaactgcgtccgttttcctagcagcaatttggctattcctaatcac
tttgtaaagactatcttatcccaaggacatctgactcccctacctctttatgtctgccca
gtgtattgggcatatgactatgctttgagagtgtatcctgtgcccgatctacttgtcatt
gcagacaaatatgatcctttcactacgacaaataccgaatgcctctgcataaaccctggc
tcttttccaagaagtggattttcattcaaagttttttatccttctaataagacagtagaa
gatagcaaacttcaaggcttttga

KEGG   Homo sapiens (human): 54107
Entry
54107             CDS       T01001                                 
Symbol
POLE3, CHARAC17, CHRAC17, CHRAC2, YBL1, p17
Name
(RefSeq) DNA polymerase epsilon 3, accessory subunit
  KO
K02326  DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03082  ATP-dependent chromatin remodeling
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    54107 (POLE3)
   03410 Base excision repair
    54107 (POLE3)
   03420 Nucleotide excision repair
    54107 (POLE3)
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    54107 (POLE3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    54107 (POLE3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    54107 (POLE3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    54107 (POLE3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     54107 (POLE3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    54107 (POLE3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   CHRAC complex
    54107 (POLE3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      54107 (POLE3)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone CENP-T_C BUD22 CIS_TMP DUF5427 SpoU_methylase DUF4746 TAF Myc_N RNA_pol_3_Rpc31 Pox_Ag35 CDC45 DDHD DUF6080 V_ATPase_I NOA36
Other DBs
NCBI-GeneID: 54107
NCBI-ProteinID: NP_001265184
OMIM: 607267
HGNC: 13546
Ensembl: ENSG00000148229
UniProt: Q9NRF9
LinkDB
Position
9:complement(113407235..113410749)
AA seq 147 aa
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
NT seq 444 nt   +upstreamnt  +downstreamnt
atggcggagaggcccgaggacctaaacctgcccaatgccgtgatcaccaggatcatcaag
gaggcgctcccggacggtgtcaacatctccaaggaggcccggagcgccatctcccgcgcc
gccagcgtcttcgtgctgtacgccacatcctgtgctaacaactttgcaatgaaaggaaag
cggaagacgctgaatgccagtgatgtgctctcagccatggaagagatggagttccagcgg
ttcgttaccccattgaaagaagctctggaagcatataggcgggagcagaaaggcaagaag
gaggcctcagagcaaaagaagaaggacaaagacaaaaaaacagactcggaagagcaagac
aagagcagggatgaggacaatgatgaagacgaagaaaggctggaagaagaagaacagaat
gaagaggaagaagtagacaactga

KEGG   Homo sapiens (human): 56655
Entry
56655             CDS       T01001                                 
Symbol
POLE4, YHHQ1, p12
Name
(RefSeq) DNA polymerase epsilon 4, accessory subunit
  KO
K03506  DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    56655 (POLE4)
   03410 Base excision repair
    56655 (POLE4)
   03420 Nucleotide excision repair
    56655 (POLE4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    56655 (POLE4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    56655 (POLE4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     56655 (POLE4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    56655 (POLE4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      56655 (POLE4)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone TAF CENP-T_C
Other DBs
NCBI-GeneID: 56655
NCBI-ProteinID: NP_063949
OMIM: 607269
HGNC: 18755
Ensembl: ENSG00000115350
UniProt: Q9NR33
LinkDB
Position
2:74958643..74970128
AA seq 117 aa
MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAG
QEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
NT seq 354 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggcggcaggaagcgggacgccccgagaggaggagggacctgctggg
gaggcagcggcctcgcagccccaggccccaacgagtgtgcctggggctcgtctctcgagg
ttgcctctggcgcgagtgaaggccttggtgaaggcagatcccgacgtgacgctagcggga
caggaagccatcttcattctggcacgagccgcggaactgtttgtggagaccattgcaaaa
gatgcctactgttgcgctcagcagggaaaaaggaaaacccttcagaggagagacttggat
aatgcaatagaagctgtggatgaatttgcttttctggaaggtactttagattga

KEGG   Homo sapiens (human): 51426
Entry
51426             CDS       T01001                                 
Symbol
POLK, DINB1, DINP, POLQ
Name
(RefSeq) DNA polymerase kappa
  KO
K03511  DNA polymerase kappa [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05216  Thyroid cancer
hsa05217  Basal cell carcinoma
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06165  Epstein-Barr virus (EBV)
nt06240  Transcription (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06269  Basal cell carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06276  Chronic myeloid leukemia
nt06502  Nucleotide excision repair
nt06506  Double-strand break repair
  Element
N00115  Mutation-inactivated TP53 to transcription
N00223  EBV EBNA1 to p53-mediated transcription
N00263  EBV EBNA3C to p53-mediated transcription
N00481  EBV BZLF1 to p53-mediated transcription
N01431  Core NER reaction
N01452  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    51426 (POLK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    51426 (POLK)
   05202 Transcriptional misregulation in cancer
    51426 (POLK)
  09162 Cancer: specific types
   05210 Colorectal cancer
    51426 (POLK)
   05212 Pancreatic cancer
    51426 (POLK)
   05225 Hepatocellular carcinoma
    51426 (POLK)
   05226 Gastric cancer
    51426 (POLK)
   05214 Glioma
    51426 (POLK)
   05216 Thyroid cancer
    51426 (POLK)
   05220 Chronic myeloid leukemia
    51426 (POLK)
   05217 Basal cell carcinoma
    51426 (POLK)
   05218 Melanoma
    51426 (POLK)
   05213 Endometrial cancer
    51426 (POLK)
   05224 Breast cancer
    51426 (POLK)
   05222 Small cell lung cancer
    51426 (POLK)
   05223 Non-small cell lung cancer
    51426 (POLK)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    51426 (POLK)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    51426 (POLK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     51426 (POLK)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  TLS (translesion DNA synthesis) factors
   Y-family DNA polymerases
    51426 (POLK)
SSDB
Motif
Pfam: IMS IMS_C IMS_HHH ATP-cone Zn_SUZ12
Other DBs
NCBI-GeneID: 51426
NCBI-ProteinID: NP_057302
OMIM: 605650
HGNC: 9183
Ensembl: ENSG00000122008
UniProt: Q9UBT6
Structure
LinkDB
Position
5:75510774..75609991
AA seq 870 aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQV
NQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDN
PELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE
VKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNK
LSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFR
IEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKV
TEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER
TFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQAL
SATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQ
VLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFS
CSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALS
NKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCP
VCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTR
TKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
NT seq 2613 nt   +upstreamnt  +downstreamnt
atggatagcacaaaggagaagtgtgacagttacaaagatgatcttctgcttaggatggga
cttaatgataataaagcaggaatggaaggattagataaagagaaaattaacaaaattata
atggaagccacgaaggggtccagattttatggaaatgagctcaagaaagaaaagcaagtc
aaccaacgaattgaaaatatgatgcaacaaaaagctcaaatcaccagccaacagctaaga
aaagcacaattacaggttgacagatttgcaatggaattagaacaaagccgaaatttgagc
aataccatagtgcacattgacatggatgctttctatgcagctgtagaaatgagggacaat
ccagaattgaaggataaacccattgctgtaggatcaatgagtatgctgtctacttcaaat
taccatgcaaggagatttggtgttcgtgcagccatgccaggatttattgctaagaggctg
tgcccacaacttataatagtgccccccaactttgacaaataccgagctgtgagtaaagag
gttaaggaaatacttgctgattatgatcccaattttatggccatgagtcttgatgaagcc
tacttgaatataacaaagcacttagaagaaagacaaaattggcctgaggataaaagaagg
tatttcatcaaaatgggaagctctgtagaaaatgataatccaggaaaggaagttaataaa
ctgagtgagcatgaacgatccatctctccactactttttgaagagagtccttctgatgtg
cagcccccaggagatcctttccaagtgaactttgaagaacaaaacaatcctcaaatactc
caaaactcagttgtttttggaacatcagcccaggaagtggtaaaggaaattcgtttcaga
attgagcagaaaacaacactgacagccagtgcaggcattgccccaaatacaatgttagca
aaagtatgcagtgataagaataaaccaaatggacaataccaaattcttcccaatagacaa
gctgtgatggacttcatcaaggatttacccattagaaaggtttctggaataggaaaagtt
acagagaaaatgttaaaggcccttggaattattacatgtacagaactttaccaacagagg
gcattgctttctctccttttctctgaaacatcttggcattatttccttcatatctccttg
ggtctaggttcaacacacctgacgagggatggagagaggaaaagtatgagcgttgagagg
acattcagtgagataaataaagcggaagagcaatacagcctatgtcaagaactttgcagt
gagcttgctcaggatctacagaaagaaagacttaagggtagaactgttaccattaagttg
aagaatgtgaattttgaagtaaaaactcgtgcatctacagtttcatctgttgtttctact
gcagaagaaatatttgccattgctaaggaattgctaaaaacagaaattgatgctgatttt
ccacatcccttgagattaaggcttatgggtgttcggatatctagttttcccaatgaagag
gacaggaaacaccaacaaaggagcattattggctttttacaggctggaaaccaagccctg
tcagccactgagtgtacattagagaaaactgacaaagataagtttgtaaaacctctagaa
atgtctcataagaagagtttctttgataaaaaacgatcagaaaggaaatggagtcaccaa
gatacatttaaatgtgaagccgtgaataaacaaagtttccagacatcacaaccattccaa
gttttaaagaagaagatgaatgagaatttggaaatatcagagaattcagatgactgtcag
atacttacctgtcctgtttgctttagggctcaagggtgcatcagtctggaagccttgaat
aaacatgtagatgaatgtcttgatggaccttcaatcagtgaaaactttaaaatgttctcg
tgttcacatgtttctgctaccaaagttaacaagaaagaaaatgttcctgcttcttcactt
tgtgagaagcaagattatgaagcccatccaaaaattaaagaaatatcttcagtagattgt
atagctttagtagatactatagataactcatctaaagcagaaagcatagatgctttaagt
aataagcatagcaaggaagaatgttctagtctcccaagcaagtcttttaatattgaacac
tgtcatcagaattcttcttctactgtttcattggaaaacgaagatgttggatcatttaga
caagaataccgccagccttacttatgtgaagtgaaaacaggccaagctctagtttgtcct
gtttgtaacgtagaacaaaagacttcagatctaaccctgttcaatgtgcatgtggatgtt
tgcttaaataaaagttttatccaagaattaagaaaggataaatttaacccagttaatcaa
cccaaagaaagctccagaagtactggtagctcaagtggagtacagaaggctgtaacaaga
acaaaaaggccaggattgatgacaaagtactcaacatcaaagaaaataaaaccaaacaat
cccaaacatacccttgatatattttttaagtaa

KEGG   Homo sapiens (human): 5429
Entry
5429              CDS       T01001                                 
Symbol
POLH, RAD30, RAD30A, XP-V, XPV
Name
(RefSeq) DNA polymerase eta
  KO
K03509  DNA polymerase eta [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa03460  Fanconi anemia pathway
Network
nt06502  Nucleotide excision repair
nt06506  Double-strand break repair
  Element
N01431  Core NER reaction
N01452  Homologous recombination
Disease
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    5429 (POLH)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    5429 (POLH)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5429 (POLH)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5429 (POLH)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  TLS (translesion DNA synthesis) factors
   Y-family DNA polymerases
    5429 (POLH)
SSDB
Motif
Pfam: IMS POLH-Rev1_HhH zf_UBZ IMS_HHH_1 IMS_C IMS_HHH
Other DBs
NCBI-GeneID: 5429
NCBI-ProteinID: NP_006493
OMIM: 603968
HGNC: 9181
Ensembl: ENSG00000170734
UniProt: Q9Y253
Structure
LinkDB
Position
6:43576185..43620523
AA seq 713 aa
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVT
RSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVD
LTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQI
DNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSH
GSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLT
MLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSL
ESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLK
QKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHN
SQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQ
KSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
NT seq 2142 nt   +upstreamnt  +downstreamnt
atggctactggacaggatcgagtggttgctctcgtggacatggactgtttttttgttcaa
gtggagcagcggcaaaatcctcatttgaggaataaaccttgtgcagttgtacagtacaaa
tcatggaagggtggtggaataattgcagtgagttatgaagctcgtgcatttggagtcact
agaagtatgtgggcagatgatgctaagaagttatgtccagatcttctactggcacaagtt
cgtgagtcccgtgggaaagctaacctcaccaagtaccgggaagccagtgttgaagtgatg
gagataatgtctcgttttgctgtgattgaacgtgccagcattgatgaggcttacgtagat
ctgaccagtgctgtacaagagagactacaaaagctacaaggtcagcctatctcggcagac
ttgttgccaagcacttacattgaagggttgccccaaggccctacaacggcagaagagact
gttcagaaagaggggatgcgaaaacaaggcttatttcaatggctcgattctcttcagatt
gataacctcacctctccagacctgcagctcaccgtgggagcagtgattgtggaggaaatg
agagcagccatagagagggagactggttttcagtgttcagctggaatttcacacaataag
gtcctggcaaaactggcctgtggactaaacaagcccaaccgccaaaccctggtttcacat
gggtcagtcccacagctcttcagccaaatgcccattcgcaaaatccgtagtcttggagga
aagctaggggcctctgtcattgagatcctagggatagaatacatgggtgaactgacccag
ttcactgaatcccagctccagagtcattttggggagaagaatgggtcttggctatatgcc
atgtgccgagggattgaacatgatccagttaaacccaggcaactacccaaaaccattggc
tgtagtaagaacttcccaggaaaaacagctcttgctactcgggaacaggtacaatggtgg
ctgttgcaattagcccaggaactagaggagagactgactaaagaccgaaatgataatgac
agggtagccacccagctggttgtgagcattcgtgtacaaggagacaaacgcctcagcagc
ctgcgccgctgctgtgcccttacccgctatgatgctcacaagatgagccatgatgcattt
actgtcatcaagaactgtaatacttctggaatccagacagaatggtctcctcctctcaca
atgcttttcctctgtgctacaaaattttctgcctctgccccttcatcttctacagacatc
accagcttcttgagcagtgacccaagttctctgccaaaggtgccagttaccagctcagaa
gctaagacccagggaagtggcccagcggtgacagccactaagaaagcaaccacgtctctg
gaatcattcttccaaaaagctgcagaaaggcagaaagttaaagaagcttcgctttcatct
cttactgctcccactcaggctcccatgagcaattcaccatccaagccctcattacctttt
caaaccagtcaaagtacaggaactgagcccttctttaagcagaaaagtctgcttctaaag
cagaaacagcttaataattcttcagtttcttccccccaacaaaacccatggtccaactgt
aaagcattaccaaactctttaccaacagagtatccagggtgtgtccctgtttgtgaaggg
gtgtcgaagctagaagaatcctctaaagcaactcctgcagagatggatttggcccacaac
agccaaagcatgcacgcctcttcagcttccaaatctgtgctggaggtgactcagaaagca
accccaaatccaagtcttctagctgctgaggaccaagtgccctgtgagaagtgtggctcc
ctggtaccggtatgggatatgccagaacacatggactatcattttgcattggagttgcag
aaatcctttttgcagccccactcttcaaacccccaggttgtttctgccgtatctcatcaa
ggcaaaagaaatcccaagagccctttggcctgcactaataaacgccccaggcctgagggc
atgcaaacattggaatcattttttaagccattaacacattag

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