KEGG   Homo sapiens (human): 801
Entry
801               CDS       T01001                                 
Symbol
CALM1, CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, PHKD1, caM
Name
(RefSeq) calmodulin 1
  KO
K02183  calmodulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05133  Pertussis
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05214  Glioma
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06537  TCR/BCR signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00401  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00487  BCR-PLCG-Calcineurin signaling pathway
N01644  Lysosomal Ca2+ release
N01647  Ca2+/CAM-CN signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01649  Ca2+/CAM-VGCC/RYR signaling pathway
Disease
H00720  Long QT syndrome
H01019  Catecholaminergic polymorphic ventricular tachycardia
Drug target
Lubeluzole: D04789
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    801 (CALM1)
   04015 Rap1 signaling pathway
    801 (CALM1)
   04371 Apelin signaling pathway
    801 (CALM1)
   04020 Calcium signaling pathway
    801 (CALM1)
   04070 Phosphatidylinositol signaling system
    801 (CALM1)
   04024 cAMP signaling pathway
    801 (CALM1)
   04022 cGMP-PKG signaling pathway
    801 (CALM1)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    801 (CALM1)
   04218 Cellular senescence
    801 (CALM1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    801 (CALM1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    801 (CALM1)
   04922 Glucagon signaling pathway
    801 (CALM1)
   04912 GnRH signaling pathway
    801 (CALM1)
   04915 Estrogen signaling pathway
    801 (CALM1)
   04921 Oxytocin signaling pathway
    801 (CALM1)
   04916 Melanogenesis
    801 (CALM1)
   04924 Renin secretion
    801 (CALM1)
   04925 Aldosterone synthesis and secretion
    801 (CALM1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    801 (CALM1)
   04270 Vascular smooth muscle contraction
    801 (CALM1)
  09154 Digestive system
   04970 Salivary secretion
    801 (CALM1)
   04971 Gastric acid secretion
    801 (CALM1)
  09156 Nervous system
   04728 Dopaminergic synapse
    801 (CALM1)
   04720 Long-term potentiation
    801 (CALM1)
   04722 Neurotrophin signaling pathway
    801 (CALM1)
  09157 Sensory system
   04744 Phototransduction
    801 (CALM1)
   04740 Olfactory transduction
    801 (CALM1)
   04750 Inflammatory mediator regulation of TRP channels
    801 (CALM1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    801 (CALM1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    801 (CALM1)
  09162 Cancer: specific types
   05214 Glioma
    801 (CALM1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    801 (CALM1)
   05163 Human cytomegalovirus infection
    801 (CALM1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    801 (CALM1)
  09171 Infectious disease: bacterial
   05133 Pertussis
    801 (CALM1)
   05152 Tuberculosis
    801 (CALM1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    801 (CALM1)
   05012 Parkinson disease
    801 (CALM1)
   05022 Pathways of neurodegeneration - multiple diseases
    801 (CALM1)
  09165 Substance dependence
   05031 Amphetamine addiction
    801 (CALM1)
   05034 Alcoholism
    801 (CALM1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    801 (CALM1)
   05418 Fluid shear stress and atherosclerosis
    801 (CALM1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    801 (CALM1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    801 (CALM1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    801 (CALM1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    801 (CALM1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Regulatory subunits
     801 (CALM1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    801 (CALM1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Centriole replication proteins
     801 (CALM1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   801 (CALM1)
SSDB
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 EF-hand_9 AIF-1 EF-hand_4 SPARC_Ca_bdg EF-hand_11 UPF0154 EFhand_Ca_insen Dockerin_1 Caleosin TerB DUF5580_M DUF1103 Poly_export SurA_N_2 SurA_N_3 Fe_hyd_lg_C PA_Ig-like
Other DBs
NCBI-GeneID: 801
NCBI-ProteinID: NP_008819
OMIM: 114180
HGNC: 1442
Ensembl: ENSG00000198668
UniProt: P0DP23 P0DP24 P0DP25 B4DJ51
Structure
LinkDB
Position
14:90396502..90408268
AA seq 149 aa
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
NT seq 450 nt   +upstreamnt  +downstreamnt
atggctgatcagctgaccgaagaacagattgctgaattcaaggaagccttctccctattt
gataaagatggcgatggcaccatcacaacaaaggaacttggaactgtcatgaggtcactg
ggtcagaacccaacagaagctgaattgcaggatatgatcaatgaagtggatgctgatggt
aatggcaccattgacttccccgaatttttgactatgatggctagaaaaatgaaagataca
gatagtgaagaagaaatccgtgaggcattccgagtctttgacaaggatggcaatggttat
atcagtgcagcagaactacgtcacgtcatgacaaacttaggagaaaaactaacagatgaa
gaagtagatgaaatgatcagagaagcagatattgatggagacggacaagtcaactatgaa
gaattcgtacagatgatgactgcaaaatga

KEGG   Homo sapiens (human): 805
Entry
805               CDS       T01001                                 
Symbol
CALM2, CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM
Name
(RefSeq) calmodulin 2
  KO
K02183  calmodulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05133  Pertussis
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05214  Glioma
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06537  TCR/BCR signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00401  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00487  BCR-PLCG-Calcineurin signaling pathway
N01644  Lysosomal Ca2+ release
N01647  Ca2+/CAM-CN signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01649  Ca2+/CAM-VGCC/RYR signaling pathway
Disease
H00720  Long QT syndrome
Drug target
Lubeluzole: D04789
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    805 (CALM2)
   04015 Rap1 signaling pathway
    805 (CALM2)
   04371 Apelin signaling pathway
    805 (CALM2)
   04020 Calcium signaling pathway
    805 (CALM2)
   04070 Phosphatidylinositol signaling system
    805 (CALM2)
   04024 cAMP signaling pathway
    805 (CALM2)
   04022 cGMP-PKG signaling pathway
    805 (CALM2)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    805 (CALM2)
   04218 Cellular senescence
    805 (CALM2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    805 (CALM2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    805 (CALM2)
   04922 Glucagon signaling pathway
    805 (CALM2)
   04912 GnRH signaling pathway
    805 (CALM2)
   04915 Estrogen signaling pathway
    805 (CALM2)
   04921 Oxytocin signaling pathway
    805 (CALM2)
   04916 Melanogenesis
    805 (CALM2)
   04924 Renin secretion
    805 (CALM2)
   04925 Aldosterone synthesis and secretion
    805 (CALM2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    805 (CALM2)
   04270 Vascular smooth muscle contraction
    805 (CALM2)
  09154 Digestive system
   04970 Salivary secretion
    805 (CALM2)
   04971 Gastric acid secretion
    805 (CALM2)
  09156 Nervous system
   04728 Dopaminergic synapse
    805 (CALM2)
   04720 Long-term potentiation
    805 (CALM2)
   04722 Neurotrophin signaling pathway
    805 (CALM2)
  09157 Sensory system
   04744 Phototransduction
    805 (CALM2)
   04740 Olfactory transduction
    805 (CALM2)
   04750 Inflammatory mediator regulation of TRP channels
    805 (CALM2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    805 (CALM2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    805 (CALM2)
  09162 Cancer: specific types
   05214 Glioma
    805 (CALM2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    805 (CALM2)
   05163 Human cytomegalovirus infection
    805 (CALM2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    805 (CALM2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    805 (CALM2)
   05152 Tuberculosis
    805 (CALM2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    805 (CALM2)
   05012 Parkinson disease
    805 (CALM2)
   05022 Pathways of neurodegeneration - multiple diseases
    805 (CALM2)
  09165 Substance dependence
   05031 Amphetamine addiction
    805 (CALM2)
   05034 Alcoholism
    805 (CALM2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    805 (CALM2)
   05418 Fluid shear stress and atherosclerosis
    805 (CALM2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    805 (CALM2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    805 (CALM2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    805 (CALM2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    805 (CALM2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Regulatory subunits
     805 (CALM2)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    805 (CALM2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Centriole replication proteins
     805 (CALM2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   805 (CALM2)
SSDB
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 EF-hand_9 AIF-1 EF-hand_4 SPARC_Ca_bdg EF-hand_11 UPF0154 EFhand_Ca_insen Dockerin_1 Caleosin TerB DUF5580_M DUF1103 Poly_export SurA_N_2 SurA_N_3 Fe_hyd_lg_C PA_Ig-like
Other DBs
NCBI-GeneID: 805
NCBI-ProteinID: NP_001734
OMIM: 114182
HGNC: 1445
Ensembl: ENSG00000143933
UniProt: P0DP23 P0DP24 P0DP25 B4DJ51
Structure
LinkDB
Position
2:complement(47160082..47176936)
AA seq 149 aa
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
NT seq 450 nt   +upstreamnt  +downstreamnt
atggctgaccaactgactgaagagcagattgcagaattcaaagaagctttttcactattt
gacaaagatggtgatggaactataacaacaaaggaattgggaactgtaatgagatctctt
gggcagaatcccacagaagcagagttacaggacatgattaatgaagtagatgctgatggt
aatggcacaattgacttccctgaatttctgacaatgatggcaagaaaaatgaaagacaca
gacagtgaagaagaaattagagaagcattccgtgtgtttgataaggatggcaatggctat
attagtgctgcagaacttcgccatgtgatgacaaaccttggagagaagttaacagatgaa
gaagttgatgaaatgatcagggaagcagatattgatggtgatggtcaagtaaactatgaa
gagtttgtacaaatgatgacagcaaagtga

KEGG   Homo sapiens (human): 808
Entry
808               CDS       T01001                                 
Symbol
CALM3, CALM, CAM1, CAM2, CAMB, CPVT6, CaM, CaMIII, HEL-S-72, LQT16, PHKD, PHKD3
Name
(RefSeq) calmodulin 3
  KO
K02183  calmodulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05133  Pertussis
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05214  Glioma
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06537  TCR/BCR signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00401  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00487  BCR-PLCG-Calcineurin signaling pathway
N01644  Lysosomal Ca2+ release
N01647  Ca2+/CAM-CN signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01649  Ca2+/CAM-VGCC/RYR signaling pathway
Disease
H00720  Long QT syndrome
H01019  Catecholaminergic polymorphic ventricular tachycardia
Drug target
Lubeluzole: D04789
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    808 (CALM3)
   04015 Rap1 signaling pathway
    808 (CALM3)
   04371 Apelin signaling pathway
    808 (CALM3)
   04020 Calcium signaling pathway
    808 (CALM3)
   04070 Phosphatidylinositol signaling system
    808 (CALM3)
   04024 cAMP signaling pathway
    808 (CALM3)
   04022 cGMP-PKG signaling pathway
    808 (CALM3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    808 (CALM3)
   04218 Cellular senescence
    808 (CALM3)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    808 (CALM3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    808 (CALM3)
   04922 Glucagon signaling pathway
    808 (CALM3)
   04912 GnRH signaling pathway
    808 (CALM3)
   04915 Estrogen signaling pathway
    808 (CALM3)
   04921 Oxytocin signaling pathway
    808 (CALM3)
   04916 Melanogenesis
    808 (CALM3)
   04924 Renin secretion
    808 (CALM3)
   04925 Aldosterone synthesis and secretion
    808 (CALM3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    808 (CALM3)
   04270 Vascular smooth muscle contraction
    808 (CALM3)
  09154 Digestive system
   04970 Salivary secretion
    808 (CALM3)
   04971 Gastric acid secretion
    808 (CALM3)
  09156 Nervous system
   04728 Dopaminergic synapse
    808 (CALM3)
   04720 Long-term potentiation
    808 (CALM3)
   04722 Neurotrophin signaling pathway
    808 (CALM3)
  09157 Sensory system
   04744 Phototransduction
    808 (CALM3)
   04740 Olfactory transduction
    808 (CALM3)
   04750 Inflammatory mediator regulation of TRP channels
    808 (CALM3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    808 (CALM3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    808 (CALM3)
  09162 Cancer: specific types
   05214 Glioma
    808 (CALM3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    808 (CALM3)
   05163 Human cytomegalovirus infection
    808 (CALM3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    808 (CALM3)
  09171 Infectious disease: bacterial
   05133 Pertussis
    808 (CALM3)
   05152 Tuberculosis
    808 (CALM3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    808 (CALM3)
   05012 Parkinson disease
    808 (CALM3)
   05022 Pathways of neurodegeneration - multiple diseases
    808 (CALM3)
  09165 Substance dependence
   05031 Amphetamine addiction
    808 (CALM3)
   05034 Alcoholism
    808 (CALM3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    808 (CALM3)
   05418 Fluid shear stress and atherosclerosis
    808 (CALM3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    808 (CALM3)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    808 (CALM3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    808 (CALM3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    808 (CALM3)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Regulatory subunits
     808 (CALM3)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    808 (CALM3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Centriole replication proteins
     808 (CALM3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   808 (CALM3)
SSDB
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 EF-hand_9 AIF-1 EF-hand_4 SPARC_Ca_bdg EF-hand_11 UPF0154 EFhand_Ca_insen Dockerin_1 Caleosin TerB DUF5580_M DUF1103 Poly_export SurA_N_2 SurA_N_3 Fe_hyd_lg_C PA_Ig-like
Other DBs
NCBI-GeneID: 808
NCBI-ProteinID: NP_001316851
OMIM: 114183
HGNC: 1449
Ensembl: ENSG00000160014
UniProt: P0DP23 P0DP24 P0DP25 B4DJ51
Structure
LinkDB
Position
19:46601074..46610782
AA seq 149 aa
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
NT seq 450 nt   +upstreamnt  +downstreamnt
atggctgaccagctgactgaggagcagattgcagagttcaaggaggccttctccctcttt
gacaaggatggagatggcactatcaccaccaaggagttggggacagtgatgagatccctg
ggacagaaccccactgaagcagagctgcaggatatgatcaatgaggtggatgcagatggg
aacgggaccattgacttcccggagttcctgaccatgatggccagaaagatgaaggacaca
gacagtgaggaggagatccgagaggcgttccgtgtctttgacaaggatgggaatggctac
atcagcgccgcagagctgcgtcacgtaatgacgaacctgggggagaagctgaccgatgag
gaggtggatgagatgatcagggaggctgacatcgatggagatggccaggtcaattatgaa
gagtttgtacagatgatgactgcaaagtga

KEGG   Homo sapiens (human): 8536
Entry
8536              CDS       T01001                                 
Symbol
CAMK1, CAMKI
Name
(RefSeq) calcium/calmodulin dependent protein kinase I
  KO
K08794  calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa05214  Glioma
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    8536 (CAMK1)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    8536 (CAMK1)
   04925 Aldosterone synthesis and secretion
    8536 (CAMK1)
 09160 Human Diseases
  09162 Cancer: specific types
   05214 Glioma
    8536 (CAMK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8536 (CAMK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     8536 (CAMK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK1 family [OT]
   8536 (CAMK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Kdo Pkinase_fungal APH Tyrosinase
Other DBs
NCBI-GeneID: 8536
NCBI-ProteinID: NP_003647
OMIM: 604998
HGNC: 1459
Ensembl: ENSG00000134072
UniProt: Q14012 B0YIY3
Structure
LinkDB
Position
3:complement(9757347..9769947)
AA seq 370 aa
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
ELSPTLPHQL
NT seq 1113 nt   +upstreamnt  +downstreamnt
atgctgggggcagtggaaggccccaggtggaagcaggcggaggacattagagacatctac
gacttccgagatgttctgggcacgggggccttctcggaggtgatcctggcagaagataag
aggacgcagaagctggtggccatcaaatgcattgccaaggaggccctggagggcaaggaa
ggcagcatggagaatgagattgctgtcctgcacaagatcaagcaccccaacattgtagcc
ctggatgacatctatgagagtgggggccacctctacctcatcatgcagctggtgtcgggt
ggggagctctttgaccgtattgtggaaaaaggcttctacacggagcgggacgccagccgc
ctcatcttccaggtgctggatgctgtgaaatacctgcatgacctgggcattgtacaccgg
gatctcaagccagagaatctgctgtactacagcctggatgaagactccaaaatcatgatc
tccgactttggcctctccaagatggaggacccgggcagtgtgctctccaccgcctgtgga
actccgggatacgtggcccctgaagtcctggcccagaagccctacagcaaggctgtggat
tgctggtccataggtgtcatcgcctacatcttgctctgcggttaccctcccttctatgac
gagaatgatgccaaactctttgaacagattttgaaggccgagtacgagtttgactctcct
tactgggacgacatctctgactctgccaaagatttcatccggcacttgatggagaaggac
ccagagaaaagattcacctgtgagcaggccttgcagcacccatggattgcaggagataca
gctctagataagaatatccaccagtcggtgagtgagcagatcaagaagaactttgccaag
agcaagtggaagcaagccttcaatgccacggctgtggtgcggcacatgaggaaactgcag
ctgggcaccagccaggaggggcaggggcagacggcgagccatggggagctgctgacacca
gtggctggggggccggcagctggctgttgctgtcgagactgctgcgtggagccgggcaca
gaactgtcccccacactgccccaccagctctag

KEGG   Homo sapiens (human): 57118
Entry
57118             CDS       T01001                                 
Symbol
CAMK1D, CKLiK, CaM-K1, CaMKID
Name
(RefSeq) calcium/calmodulin dependent protein kinase ID
  KO
K08794  calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa05214  Glioma
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    57118 (CAMK1D)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    57118 (CAMK1D)
   04925 Aldosterone synthesis and secretion
    57118 (CAMK1D)
 09160 Human Diseases
  09162 Cancer: specific types
   05214 Glioma
    57118 (CAMK1D)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    57118 (CAMK1D)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     57118 (CAMK1D)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK1 family [OT]
   57118 (CAMK1D)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Kdo RIO1 Pkinase_fungal 5_nucleotid Tyrosinase
Other DBs
NCBI-GeneID: 57118
NCBI-ProteinID: NP_705718
OMIM: 607957
HGNC: 19341
Ensembl: ENSG00000183049
UniProt: Q8IU85 Q5SQQ7
Structure
LinkDB
Position
10:12349547..12835545
AA seq 385 aa
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK
GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD
ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF
DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS
SGVSGVGAERRPRPTTVTAVHSGSK
NT seq 1158 nt   +upstreamnt  +downstreamnt
atggcccgggagaacggcgagagcagctcctcctggaaaaagcaagctgaagacatcaag
aagatcttcgagttcaaagagaccctcggaaccggggccttttccgaagtggttttagct
gaagagaaggcaactggcaagctctttgctgtgaagtgtatccctaagaaggcgctgaag
ggcaaggaaagcagcatagagaatgagatagccgtcctgagaaagattaagcatgaaaat
attgttgccctggaagacatttatgaaagcccaaatcacctgtacttggtcatgcagctg
gtgtccggtggagagctgtttgaccggatagtggagaaggggttttatacagagaaggat
gccagcactctgatccgccaagtcttggacgccgtgtactatctccacagaatgggcatc
gtccacagagacctcaagcccgaaaatctcttgtactacagtcaagatgaggagtccaaa
ataatgatcagtgactttggattgtcaaaaatggagggcaaaggagatgtgatgtccact
gcctgtggaactccaggctatgtcgctcctgaagtcctcgcccagaaaccttacagcaaa
gccgttgactgctggtccatcggagtgattgcctacatcttgctctgcggctaccctcct
ttttatgatgaaaatgactccaagctctttgagcagatcctcaaggcggaatatgagttt
gactctccctactgggatgacatctccgactctgcaaaagacttcattcggaacctgatg
gagaaggacccgaataaaagatacacgtgtgagcaggcagctcggcacccatggatcgct
ggtgacacagccctcaacaaaaacatccacgagtccgtcagcgcccagatccggaaaaac
tttgccaagagcaaatggagacaagcatttaatgccacggccgtcgtcagacatatgaga
aaactacacctcggcagcagcctggacagttcaaatgcaagtgtttcgagcagcctcagt
ttggccagccaaaaagactgtctggcaccttccacgctctgtagtttcatttcttcttcg
tcgggggtctcaggagttggagccgagcggagacccaggcccaccactgtgacggcagtg
cactctggaagcaagtga

KEGG   Homo sapiens (human): 57172
Entry
57172             CDS       T01001                                 
Symbol
CAMK1G, CLICK3, CLICKIII, VWS1
Name
(RefSeq) calcium/calmodulin dependent protein kinase IG
  KO
K08794  calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa05214  Glioma
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    57172 (CAMK1G)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    57172 (CAMK1G)
   04925 Aldosterone synthesis and secretion
    57172 (CAMK1G)
 09160 Human Diseases
  09162 Cancer: specific types
   05214 Glioma
    57172 (CAMK1G)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    57172 (CAMK1G)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     57172 (CAMK1G)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK1 family [OT]
   57172 (CAMK1G)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 FTA2 Kdo RIO1 Pkinase_fungal DUF5898 5_nucleotid YrbL-PhoP_reg CsgA
Other DBs
NCBI-GeneID: 57172
NCBI-ProteinID: NP_065172
OMIM: 614994
HGNC: 14585
Ensembl: ENSG00000008118
UniProt: Q96NX5
Structure
LinkDB
Position
1:209583714..209613939
AA seq 476 aa
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
NT seq 1431 nt   +upstreamnt  +downstreamnt
atgggtcgaaaggaagaagatgactgcagttcctggaagaaacagaccaccaacatccgg
aaaaccttcatttttatggaagtgctgggatcaggagctttctcagaagttttcctggtg
aagcaaagactgactgggaagctctttgctctgaagtgcatcaagaagtcacctgccttc
cgggacagcagcctggagaatgagattgctgtgttgaaaaagatcaagcatgaaaacatt
gtgaccctggaggacatctatgagagcaccacccactactacctggtcatgcagcttgtt
tctggtggggagctctttgaccggatcctggagcggggtgtctacacagagaaggatgcc
agtctggtgatccagcaggtcttgtcggcagtgaaatacctacatgagaatggcatcgtc
cacagagacttaaagcccgaaaacctgctttaccttacccctgaagagaactctaagatc
atgatcactgactttggtctgtccaagatggaacagaatggcatcatgtccactgcctgt
gggaccccaggctacgtggctccagaagtgctggcccagaaaccctacagcaaggctgtg
gattgctggtccatcggcgtcatcacctacatattgctctgtggataccccccattctat
gaagaaacggagtctaagcttttcgagaagatcaaggagggctactatgagtttgagtct
ccattctgggatgacatttctgagtcagccaaggactttatttgccacttgcttgagaag
gatccgaacgagcggtacacctgtgagaaggccttgagtcatccctggattgacggaaac
acagccctccaccgggacatctacccatcagtcagcctccagatccagaagaactttgct
aagagcaagtggaggcaagccttcaacgcagcagctgtggtgcaccacatgaggaagcta
cacatgaacctgcacagcccgggcgtccgcccagaggtggagaacaggccgcctgaaact
caagcctcagaaacctctagacccagctcccctgagatcaccatcaccgaggcacctgtc
ctggaccacagtgtagcactccctgccctgacccaattaccctgccagcatggccgccgg
cccactgcccctggtggcaggtccctcaactgcctggtcaatggctccctccacatcagc
agcagcctggtgcccatgcatcaggggtccctggccgccgggccctgtggctgctgctcc
agctgcctgaacattgggagcaaaggaaagtcctcctactgctctgagcccacactcctc
aaaaaggccaacaaaaaacagaacttcaagtcggaggtcatggtaccagttaaagccagt
ggcagctcccactgccgggcagggcagactggagtctgtctcattatgtga

KEGG   Homo sapiens (human): 815
Entry
815               CDS       T01001                                 
Symbol
CAMK2A, CAMKA, CaMKIINalpha, CaMKIIalpha, MRD53, MRT63
Name
(RefSeq) calcium/calmodulin dependent protein kinase II alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04148  Efferocytosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06535  Efferocytosis
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01775  Inactivation of CaMKII by inducing SERCA2
N01776  CaMK2-p38-MK2-ALOX5 pathway
Disease
H00768  Autosomal recessive intellectual developmental disorder
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    815 (CAMK2A)
   04310 Wnt signaling pathway
    815 (CAMK2A)
   04066 HIF-1 signaling pathway
    815 (CAMK2A)
   04020 Calcium signaling pathway
    815 (CAMK2A)
   04024 cAMP signaling pathway
    815 (CAMK2A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    815 (CAMK2A)
  09143 Cell growth and death
   04114 Oocyte meiosis
    815 (CAMK2A)
   04217 Necroptosis
    815 (CAMK2A)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    815 (CAMK2A)
   04922 Glucagon signaling pathway
    815 (CAMK2A)
   04912 GnRH signaling pathway
    815 (CAMK2A)
   04921 Oxytocin signaling pathway
    815 (CAMK2A)
   04916 Melanogenesis
    815 (CAMK2A)
   04925 Aldosterone synthesis and secretion
    815 (CAMK2A)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    815 (CAMK2A)
  09154 Digestive system
   04971 Gastric acid secretion
    815 (CAMK2A)
  09156 Nervous system
   04725 Cholinergic synapse
    815 (CAMK2A)
   04728 Dopaminergic synapse
    815 (CAMK2A)
   04720 Long-term potentiation
    815 (CAMK2A)
   04722 Neurotrophin signaling pathway
    815 (CAMK2A)
  09157 Sensory system
   04740 Olfactory transduction
    815 (CAMK2A)
   04750 Inflammatory mediator regulation of TRP channels
    815 (CAMK2A)
  09158 Development and regeneration
   04360 Axon guidance
    815 (CAMK2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    815 (CAMK2A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    815 (CAMK2A)
   05205 Proteoglycans in cancer
    815 (CAMK2A)
  09162 Cancer: specific types
   05214 Glioma
    815 (CAMK2A)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    815 (CAMK2A)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    815 (CAMK2A)
   05022 Pathways of neurodegeneration - multiple diseases
    815 (CAMK2A)
  09165 Substance dependence
   05031 Amphetamine addiction
    815 (CAMK2A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    815 (CAMK2A)
   05415 Diabetic cardiomyopathy
    815 (CAMK2A)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    815 (CAMK2A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    815 (CAMK2A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     815 (CAMK2A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   815 (CAMK2A)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 APH Kdo SnoaL_4
Other DBs
NCBI-GeneID: 815
NCBI-ProteinID: NP_741960
OMIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808
UniProt: Q9UQM7 Q7LDD5 A8K161 Q8IWE0
Structure
LinkDB
Position
5:complement(150219491..150290130)
AA seq 478 aa
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt   +upstreamnt  +downstreamnt
atggccaccatcacctgcacccgcttcacggaagagtaccagctcttcgaggaattgggc
aagggagccttctcggtggtgcgaaggtgtgtgaaggtgctggctggccaggagtatgct
gccaagatcatcaacacaaagaagctgtcagccagagaccatcagaagctggagcgtgaa
gcccgcatctgccgcctgctgaagcaccccaacatcgtccgactacatgacagcatctca
gaggagggacaccactacctgatcttcgacctggtcactggtggggaactgtttgaagat
atcgtggcccgggagtattacagtgaggcggatgccagtcactgtatccagcagatcctg
gaggctgtgctgcactgccaccagatgggggtggtgcaccgggacctgaagcctgagaat
ctgttgctggcctccaagctcaagggtgccgcagtgaagctggcagactttggcctggcc
atagaggtggagggggagcagcaggcatggtttgggtttgcagggactcctggatatctc
tccccagaagtgctgcggaaggacccgtacgggaagcctgtggacctgtgggcttgtggg
gtcatcctgtacatcctgctggttgggtaccccccgttctgggatgaggaccagcaccgc
ctgtaccagcagatcaaagccggcgcctatgatttcccatcgccggaatgggacactgtc
accccggaagccaaggatctgatcaataagatgctgaccattaacccatccaaacgcatc
acagctgccgaagcccttaagcacccctggatctcgcaccgctccaccgtggcatcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccattctcaccacgatgctggccaccaggaacttctccggagggaagagtggggga
aacaagaagagcgatggtgtgaaggaatcctcagagagcaccaacaccaccatcgaggat
gaagacaccaaagtgcggaaacaggaaattataaaagtgacagagcagctgattgaagcc
ataagcaatggagattttgagtcctacacgaagatgtgcgaccctggcatgacagccttc
gaacctgaggccctggggaacctggttgagggcctggacttccatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaatccccacatccac
ctgatgggcgacgagtcagcctgcatcgcctacatccgcatcacgcagtacctggacgct
ggcggcatcccacgcaccgcccagtcggaggagacccgtgtctggcaccgccgggatggc
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccccactga

KEGG   Homo sapiens (human): 816
Entry
816               CDS       T01001                                 
Symbol
CAMK2B, CAM2, CAMK2, CAMKB, CaMKIIbeta, MRD54
Name
(RefSeq) calcium/calmodulin dependent protein kinase II beta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04148  Efferocytosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06535  Efferocytosis
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01775  Inactivation of CaMKII by inducing SERCA2
N01776  CaMK2-p38-MK2-ALOX5 pathway
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    816 (CAMK2B)
   04310 Wnt signaling pathway
    816 (CAMK2B)
   04066 HIF-1 signaling pathway
    816 (CAMK2B)
   04020 Calcium signaling pathway
    816 (CAMK2B)
   04024 cAMP signaling pathway
    816 (CAMK2B)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    816 (CAMK2B)
  09143 Cell growth and death
   04114 Oocyte meiosis
    816 (CAMK2B)
   04217 Necroptosis
    816 (CAMK2B)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    816 (CAMK2B)
   04922 Glucagon signaling pathway
    816 (CAMK2B)
   04912 GnRH signaling pathway
    816 (CAMK2B)
   04921 Oxytocin signaling pathway
    816 (CAMK2B)
   04916 Melanogenesis
    816 (CAMK2B)
   04925 Aldosterone synthesis and secretion
    816 (CAMK2B)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    816 (CAMK2B)
  09154 Digestive system
   04971 Gastric acid secretion
    816 (CAMK2B)
  09156 Nervous system
   04725 Cholinergic synapse
    816 (CAMK2B)
   04728 Dopaminergic synapse
    816 (CAMK2B)
   04720 Long-term potentiation
    816 (CAMK2B)
   04722 Neurotrophin signaling pathway
    816 (CAMK2B)
  09157 Sensory system
   04740 Olfactory transduction
    816 (CAMK2B)
   04750 Inflammatory mediator regulation of TRP channels
    816 (CAMK2B)
  09158 Development and regeneration
   04360 Axon guidance
    816 (CAMK2B)
  09159 Environmental adaptation
   04713 Circadian entrainment
    816 (CAMK2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    816 (CAMK2B)
   05205 Proteoglycans in cancer
    816 (CAMK2B)
  09162 Cancer: specific types
   05214 Glioma
    816 (CAMK2B)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    816 (CAMK2B)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    816 (CAMK2B)
   05022 Pathways of neurodegeneration - multiple diseases
    816 (CAMK2B)
  09165 Substance dependence
   05031 Amphetamine addiction
    816 (CAMK2B)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    816 (CAMK2B)
   05415 Diabetic cardiomyopathy
    816 (CAMK2B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    816 (CAMK2B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    816 (CAMK2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     816 (CAMK2B)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   816 (CAMK2B)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 APH Pkinase_fungal Kdo SnoaL_4
Other DBs
NCBI-GeneID: 816
NCBI-ProteinID: NP_001211
OMIM: 607707
HGNC: 1461
Ensembl: ENSG00000058404
UniProt: Q13554 A4D2J9
Structure
LinkDB
Position
7:complement(44217154..44326013)
AA seq 666 aa
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
KGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTK
NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR
RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSP
ALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIK
TTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHT
TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGA
PVAPLQ
NT seq 2001 nt   +upstreamnt  +downstreamnt
atggccaccacggtgacctgcacccgcttcaccgacgagtaccagctctacgaggatatt
ggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtat
gcagccaagatcatcaacaccaagaagctgtcagccagagatcaccagaagctggagaga
gaggctcggatctgccgccttctgaagcattccaacatcgtgcgtctccacgacagcatc
tccgaggagggcttccactacctggtcttcgatctggtcactggtggggagctctttgaa
gacattgtggcgagagagtactacagcgaggctgatgccagtcactgtatccagcagatc
ctggaggccgttctccattgtcaccaaatgggggtcgtccacagagacctcaagccggag
aacctgcttctggccagcaagtgcaaaggggctgcagtgaagctggcagacttcggccta
gctatcgaggtgcagggggaccagcaggcatggtttggtttcgctggcacaccaggctac
ctgtcccctgaggtccttcgcaaagaggcgtatggcaagcctgtggacatctgggcatgt
ggggtgatcctgtacatcctgctcgtgggctacccacccttctgggacgaggaccagcac
aagctgtaccagcagatcaaggctggtgcctatgacttcccgtcccctgagtgggacacc
gtcactcctgaagccaaaaacctcatcaaccagatgctgaccatcaaccctgccaagcgc
atcacagcccatgaggccctgaagcacccgtgggtctgccaacgctccacggtagcatcc
atgatgcacagacaggagactgtggagtgtctgaaaaagttcaatgccaggagaaagctc
aagggagccatcctcaccaccatgctggccacacggaatttctcagtgggcagacagacc
accgctccggccacaatgtccaccgcggcctccggcaccaccatggggctggtggaacaa
gccaagagtttactcaacaagaaagcagatggagtcaagccccagacgaatagcaccaaa
aacagtgcagccgccaccagccccaaagggacgcttcctcctgccgccctggagcctcaa
accaccgtcatccataacccagtggacgggattaaggagtcttctgacagtgccaatacc
accatagaggatgaagacgctaaagcccccagggtccccgacatcctgagctcagtgagg
aggggctcgggagccccagaagccgaggggcccctgccctgcccatctccggctcccttt
agccccctgccagccccatcccccaggatctctgacatcctgaactctgtgagaaggggt
tcaggaaccccagaagccgagggccccctctcagcggggcccccgccctgcctgtctccg
gctctcctaggccccctgtcctccccgtcccccaggatctctgacatcctgaactctgtg
aggaggggctcagggaccccagaagccgagggcccctcgccagtggggcccccgccctgc
ccatctccgactatccctggccccctgcccaccccatcccggaagcaggagatcattaag
accacggagcagctcatcgaggccgtcaacaacggtgactttgaggcctacgcgaaaatc
tgtgacccagggctgacctcgtttgagcctgaagcactgggcaacctggttgaagggatg
gacttccacagattctacttcgagaacctgctggccaagaacagcaagccgatccacacg
accatcctgaacccacacgtgcacgtcattggagaggatgccgcctgcatcgcttacatc
cggctcacgcagtacattgacgggcagggccggccccgcaccagccagtctgaggagacc
cgcgtgtggcaccgccgcgacggcaagtggcagaacgtgcacttccactgctcgggcgcg
cctgtggccccgctgcagtga

KEGG   Homo sapiens (human): 817
Entry
817               CDS       T01001                                 
Symbol
CAMK2D, CAMKD
Name
(RefSeq) calcium/calmodulin dependent protein kinase II delta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04148  Efferocytosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06535  Efferocytosis
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01775  Inactivation of CaMKII by inducing SERCA2
N01776  CaMK2-p38-MK2-ALOX5 pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    817 (CAMK2D)
   04310 Wnt signaling pathway
    817 (CAMK2D)
   04066 HIF-1 signaling pathway
    817 (CAMK2D)
   04020 Calcium signaling pathway
    817 (CAMK2D)
   04024 cAMP signaling pathway
    817 (CAMK2D)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    817 (CAMK2D)
  09143 Cell growth and death
   04114 Oocyte meiosis
    817 (CAMK2D)
   04217 Necroptosis
    817 (CAMK2D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    817 (CAMK2D)
   04922 Glucagon signaling pathway
    817 (CAMK2D)
   04912 GnRH signaling pathway
    817 (CAMK2D)
   04921 Oxytocin signaling pathway
    817 (CAMK2D)
   04916 Melanogenesis
    817 (CAMK2D)
   04925 Aldosterone synthesis and secretion
    817 (CAMK2D)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    817 (CAMK2D)
  09154 Digestive system
   04971 Gastric acid secretion
    817 (CAMK2D)
  09156 Nervous system
   04725 Cholinergic synapse
    817 (CAMK2D)
   04728 Dopaminergic synapse
    817 (CAMK2D)
   04720 Long-term potentiation
    817 (CAMK2D)
   04722 Neurotrophin signaling pathway
    817 (CAMK2D)
  09157 Sensory system
   04740 Olfactory transduction
    817 (CAMK2D)
   04750 Inflammatory mediator regulation of TRP channels
    817 (CAMK2D)
  09158 Development and regeneration
   04360 Axon guidance
    817 (CAMK2D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    817 (CAMK2D)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    817 (CAMK2D)
   05205 Proteoglycans in cancer
    817 (CAMK2D)
  09162 Cancer: specific types
   05214 Glioma
    817 (CAMK2D)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    817 (CAMK2D)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    817 (CAMK2D)
   05022 Pathways of neurodegeneration - multiple diseases
    817 (CAMK2D)
  09165 Substance dependence
   05031 Amphetamine addiction
    817 (CAMK2D)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    817 (CAMK2D)
   05415 Diabetic cardiomyopathy
    817 (CAMK2D)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    817 (CAMK2D)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    817 (CAMK2D)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     817 (CAMK2D)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   817 (CAMK2D)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 Pkinase_fungal Kdo SnoaL_4
Other DBs
NCBI-GeneID: 817
NCBI-ProteinID: NP_001212
OMIM: 607708
HGNC: 1462
Ensembl: ENSG00000145349
UniProt: Q13557
Structure
LinkDB
Position
4:complement(113451032..113761738)
AA seq 499 aa
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
NT seq 1500 nt   +upstreamnt  +downstreamnt
atggcttcgaccacaacctgcaccaggttcacggacgagtatcagcttttcgaggagctt
ggaaagggggcattctcagtggtgagaagatgtatgaaaattcctactggacaagaatat
gctgccaaaattatcaacaccaaaaagctttctgctagggatcatcagaaactagaaaga
gaagctagaatctgccgtcttttgaagcaccctaatattgtgcgacttcatgatagcata
tcagaagagggctttcactacttggtgtttgatttagttactggaggtgaactgtttgaa
gacatagtggcaagagaatactacagtgaagctgatgccagtcattgtatacagcagatt
ctagaaagtgttaatcattgtcacctaaatggcatagttcacagggacctgaagcctgag
aatttgcttttagctagcaaatccaagggagcagctgtgaaattggcagactttggctta
gccatagaagttcaaggggaccagcaggcgtggtttggttttgctggcacacctggatat
ctttctccagaagttttacgtaaagatccttatggaaagccagtggatatgtgggcatgt
ggtgtcattctctatattctacttgtggggtatccacccttctgggatgaagaccaacac
agactctatcagcagatcaaggctggagcttatgattttccatcaccagaatgggacacg
gtgactcctgaagccaaagacctcatcaataaaatgcttactatcaaccctgccaaacgc
atcacagcctcagaggcactgaagcacccatggatctgtcaacgttctactgttgcttcc
atgatgcacagacaggagactgtagactgcttgaagaaatttaatgctagaagaaaacta
aagggtgccatcttgacaactatgctggctacaaggaatttctcagcagccaagagtttg
ttgaagaaaccagatggagtaaaggagtcaactgagagttcaaatacaacaattgaggat
gaagatgtgaaagcacgaaagcaagagattatcaaagtcactgaacaactgatcgaagct
atcaacaatggggactttgaagcctacacaaaaatctgtgacccaggccttactgctttt
gaacctgaagctttgggtaatttagtggaagggatggattttcaccgattctactttgaa
aatgctttgtccaaaagcaataaaccaatccacactattattctaaaccctcatgtacat
ctggtaggggatgatgccgcctgcatagcatatattaggctcacacagtacatggatggc
agtggaatgccaaagacaatgcagtcagaagagactcgtgtgtggcaccgccgggatgga
aagtggcagaatgttcattttcatcgctcggggtcaccaacagtacccatcaagccaccc
tgtattccaaatgggaaagaaaacttctcaggaggcacctctttgtggcaaaacatctaa

KEGG   Homo sapiens (human): 818
Entry
818               CDS       T01001                                 
Symbol
CAMK2G, CAMK, CAMK-II, CAMKG, MRD59
Name
(RefSeq) calcium/calmodulin dependent protein kinase II gamma
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04148  Efferocytosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing syndrome
hsa04971  Gastric acid secretion
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06220  Calcium signaling (cancer)
nt06273  Glioma
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling
nt06535  Efferocytosis
  Element
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01648  Ca2+/CAM-CAMK signaling pathway
N01775  Inactivation of CaMKII by inducing SERCA2
N01776  CaMK2-p38-MK2-ALOX5 pathway
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    818 (CAMK2G)
   04310 Wnt signaling pathway
    818 (CAMK2G)
   04066 HIF-1 signaling pathway
    818 (CAMK2G)
   04020 Calcium signaling pathway
    818 (CAMK2G)
   04024 cAMP signaling pathway
    818 (CAMK2G)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    818 (CAMK2G)
  09143 Cell growth and death
   04114 Oocyte meiosis
    818 (CAMK2G)
   04217 Necroptosis
    818 (CAMK2G)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    818 (CAMK2G)
   04922 Glucagon signaling pathway
    818 (CAMK2G)
   04912 GnRH signaling pathway
    818 (CAMK2G)
   04921 Oxytocin signaling pathway
    818 (CAMK2G)
   04916 Melanogenesis
    818 (CAMK2G)
   04925 Aldosterone synthesis and secretion
    818 (CAMK2G)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    818 (CAMK2G)
  09154 Digestive system
   04971 Gastric acid secretion
    818 (CAMK2G)
  09156 Nervous system
   04725 Cholinergic synapse
    818 (CAMK2G)
   04728 Dopaminergic synapse
    818 (CAMK2G)
   04720 Long-term potentiation
    818 (CAMK2G)
   04722 Neurotrophin signaling pathway
    818 (CAMK2G)
  09157 Sensory system
   04740 Olfactory transduction
    818 (CAMK2G)
   04750 Inflammatory mediator regulation of TRP channels
    818 (CAMK2G)
  09158 Development and regeneration
   04360 Axon guidance
    818 (CAMK2G)
  09159 Environmental adaptation
   04713 Circadian entrainment
    818 (CAMK2G)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    818 (CAMK2G)
   05205 Proteoglycans in cancer
    818 (CAMK2G)
  09162 Cancer: specific types
   05214 Glioma
    818 (CAMK2G)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    818 (CAMK2G)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    818 (CAMK2G)
   05022 Pathways of neurodegeneration - multiple diseases
    818 (CAMK2G)
  09165 Substance dependence
   05031 Amphetamine addiction
    818 (CAMK2G)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    818 (CAMK2G)
   05415 Diabetic cardiomyopathy
    818 (CAMK2G)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    818 (CAMK2G)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    818 (CAMK2G)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     818 (CAMK2G)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   818 (CAMK2G)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 Pkinase_fungal Kdo ABC1 SnoaL_4
Other DBs
NCBI-GeneID: 818
NCBI-ProteinID: NP_001191421
OMIM: 602123
HGNC: 1463
Ensembl: ENSG00000148660
UniProt: Q13555
Structure
LinkDB
Position
10:complement(73812501..73874555)
AA seq 539 aa
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI
LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKPQSNNKNSL
VSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIE
AINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV
HVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
NT seq 1620 nt   +upstreamnt  +downstreamnt
atggccaccaccgccacctgcacccgtttcaccgacgactaccagctcttcgaggagctt
ggcaagggtgctttctctgtggtccgcaggtgtgtgaagaaaacctccacgcaggagtac
gcagcaaaaatcatcaataccaagaagttgtctgcccgggatcaccagaaactagaacgt
gaggctcggatatgtcgacttctgaaacatccaaacatcgtgcgcctccatgacagtatt
tctgaagaagggtttcactacctcgtgtttgaccttgttaccggcggggagctgtttgaa
gacattgtggccagagagtactacagtgaagcagatgccagccactgtatacatcagatt
ctggagagtgttaaccacatccaccagcatgacatcgtccacagggacctgaagcctgag
aacctgctgctggcgagtaaatgcaagggtgccgccgtcaagctggctgattttggccta
gccatcgaagtacagggagagcagcaggcttggtttggttttgctggcaccccaggttac
ttgtcccctgaggtcttgaggaaagatccctatggaaaacctgtggatatctgggcctgc
ggggtcatcctgtatatcctcctggtgggctatcctcccttctgggatgaggatcagcac
aagctgtatcagcagatcaaggctggagcctatgatttcccatcaccagaatgggacacg
gtaactcctgaagccaagaacttgatcaaccagatgctgaccataaacccagcaaagcgc
atcacggctgaccaggctctcaagcacccgtgggtctgtcaacgatccacggtggcatcc
atgatgcatcgtcaggagactgtggagtgtttgcgcaagttcaatgcccggagaaaactg
aagggtgccatcctcacgaccatgcttgtctccaggaacttctcagttggcaggcagagc
tccgcccccgcctcgcctgccgcgagcgccgccggcctggccgggcaagctgccaaaagc
ctattgaacaagaagtcggatggcggtgtcaagccacagagcaacaacaaaaacagtctc
gtaagcccagcccaagagcccgcgcccttgcagacggccatggagccacaaaccactgtg
gtacacaacgctacagatgggatcaagggctccacagagagctgcaacaccaccacagaa
gatgaggacctcaaagtgcgaaaacaggagatcattaagattacagaacagctgattgaa
gccatcaacaatggggactttgaggcctacacgaagatttgtgatccaggcctcacttcc
tttgagcctgaggcccttggtaacctcgtggaggggatggatttccataagttttacttt
gagaatctcctgtccaagaacagcaagcctatccataccaccatcctaaacccacacgtc
cacgtgattggggaggacgcagcgtgcatcgcctacatccgcctcacccagtacatcgac
gggcagggtcggcctcgcaccagccagtcagaagagacccgggtctggcaccgtcgggat
ggcaagtggctcaatgtccactatcactgctcaggggcccctgccgcaccgctgcagtga

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