KEGG   PATHWAY: kab00260
Entry
kab00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Kitasatospora albolonga
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kab00260  Glycine, serine and threonine metabolism
kab00260

Module
kab_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kab00260]
kab_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kab00260]
kab_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:kab00260]
kab_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kab00260]
kab_M00555  Betaine biosynthesis, choline => betaine [PATH:kab00260]
kab_M00621  Glycine cleavage system [PATH:kab00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kitasatospora albolonga [GN:kab]
Gene
B7C62_15180  aspartate kinase [KO:K00928] [EC:2.7.2.4]
B7C62_15175  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B7C62_09960  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B7C62_25710  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B7C62_25720  homoserine kinase [KO:K00872] [EC:2.7.1.39]
B7C62_19645  threonine synthase [KO:K01733] [EC:4.2.3.1]
B7C62_18070  threonine synthase [KO:K01733] [EC:4.2.3.1]
B7C62_25715  threonine synthase [KO:K01733] [EC:4.2.3.1]
B7C62_01845  threonine aldolase [KO:K01620] [EC:4.1.2.48]
B7C62_26425  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B7C62_25760  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B7C62_31500  glycerate kinase [KO:K00865] [EC:2.7.1.165]
B7C62_19350  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
B7C62_20255  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
B7C62_24100  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B7C62_03695  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B7C62_26655  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B7C62_20455  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
B7C62_05865  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
B7C62_29975  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
B7C62_29970  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
B7C62_33060  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
B7C62_09915  amine oxidase [KO:K00274] [EC:1.4.3.4]
B7C62_03315  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
B7C62_26435  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
B7C62_30035  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B7C62_07665  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B7C62_26430  glycine cleavage system protein H [KO:K02437]
B7C62_32590  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
B7C62_33385  amidinotransferase [KO:K00613] [EC:2.1.4.1]
B7C62_08835  amidinotransferase [KO:K00613] [EC:2.1.4.1]
B7C62_31640  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
B7C62_29330  choline oxidase [KO:K17755] [EC:1.1.3.17]
B7C62_29340  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B7C62_27520  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B7C62_27555  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B7C62_32070  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B7C62_02480  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
B7C62_12270  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
B7C62_17475  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
B7C62_26420  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
B7C62_23480  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
B7C62_06955  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
B7C62_06960  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
B7C62_06130  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
B7C62_28450  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
B7C62_06125  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
B7C62_06135  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
B7C62_06140  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
B7C62_10670  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
B7C62_06740  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
B7C62_31395  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kab00010  Glycolysis / Gluconeogenesis
kab00020  Citrate cycle (TCA cycle)
kab00230  Purine metabolism
kab00250  Alanine, aspartate and glutamate metabolism
kab00270  Cysteine and methionine metabolism
kab00290  Valine, leucine and isoleucine biosynthesis
kab00300  Lysine biosynthesis
kab00330  Arginine and proline metabolism
kab00460  Cyanoamino acid metabolism
kab00470  D-Amino acid metabolism
kab00564  Glycerophospholipid metabolism
kab00600  Sphingolipid metabolism
kab00620  Pyruvate metabolism
kab00630  Glyoxylate and dicarboxylate metabolism
kab00640  Propanoate metabolism
kab00680  Methane metabolism
kab00860  Porphyrin metabolism
kab00920  Sulfur metabolism
KO pathway
ko00260   
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