KEGG   PATHWAY: ko03083
Entry
ko03083                     Pathway                                
Name
Polycomb repressive complex
Class
Genetic Information Processing; Chromosome
Pathway map
ko03083  Polycomb repressive complex
ko03083

Orthology
K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
K03115  CSNK2B; casein kinase II subunit beta
K04453  MAX; Max protein
K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04683  TFDP1; transcription factor Dp-1
K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06689  UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
K08588  BAP1, UCHL2; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]
K09201  YY; transcription factor YY
K09390  E2F6; transcription factor E2F6
K09404  FOXK; forkhead box protein K
K09667  OGT; protein O-GlcNAc transferase [EC:2.4.1.255]
K10276  FBXL10_11, KDM2; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
K10695  RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10752  RBBP4, HAT2, CAF1, MIS16; histone-binding protein RBBP4
K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K11451  CBX2; chromobox protein 2
K11452  CBX4, PC2; E3 SUMO-protein ligase CBX4 [EC:2.3.2.-]
K11453  CBX6; chromobox protein 6
K11454  CBX7; chromobox protein 7
K11455  CBX8, PC3; chromobox protein 8
K11456  PHC1, EDR1; polyhomeotic-like protein 1
K11457  PHC2, EDR2; polyhomeotic-like protein 2
K11458  PHC3, EDR3; polyhomeotic-like protein 3
K11459  PCGF4, BMI1; polycomb group RING finger protein 4
K11460  PCGF2, RNF110; polycomb group RING finger protein 2
K11461  SCMH1; polycomb protein SCMH1
K11462  EED; polycomb protein EED
K11463  SUZ12; polycomb protein SUZ12
K11464  SCML1; sex comb on midleg-like protein 1
K11465  SCML2; sex comb on midleg-like protein 2
K11467  PHF1, PCL1; PHD finger protein 1
K11468  YAF2; YY1-associated factor 2
K11469  RYBP; RING1 and YY1-binding protein
K11470  PCGF6, MBLR; polycomb group RING finger protein 6
K11471  ASXL; additional sex combs-like protein
K11478  JARID2, JMJ; protein Jumonji
K11479  AURKB; aurora kinase B [EC:2.7.11.1]
K11485  MTF2, PCL2; metal regulatory transcription factor 2
K11486  PHF19, PCL3; PHD finger protein 19
K11487  PCGF1, NSPC1; polycomb group RING finger protein 1
K11488  PCGF3; polycomb group RING finger protein 3
K11489  PCGF5; polycomb group RING finger protein 5
K11586  CBX3, HP1G; chromobox protein 3
K11659  RBBP7; histone-binding protein RBBP7
K11805  DCAF7, HAN11; DDB1- and CUL4-associated factor 7
K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
K11844  USP16_45; ubiquitin carboxyl-terminal hydrolase 16/45 [EC:3.4.19.12]
K14827  IPI1, TEX10; pre-rRNA-processing protein IPI1
K14963  WDR5, SWD3, CPS30; COMPASS component SWD3
K14966  HCFC1; host cell factor 1
K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]
K17452  AEBP2; zinc finger protein AEBP2
K23214  AUTS2; autism susceptibility gene 2 protein
K23215  BCOR; bcl-6 corepressor
K23219  MBD5; methyl-CpG-binding domain protein 5
K23399  MGA; MAX gene-associated protein
K24387  L3MBTL; lethal(3)malignant brain tumor-like protein
K26199  BCORL1; BCL-6 corepressor-like protein 1
K26253  FBRS; fibrosin-1
K26254  FBRSL1; fibrosin-1-like protein
K26259  EPOP; elongin BC and Polycomb repressive complex 2-associated protein
K26260  LCOR; ligand-dependent corepressor
K26269  SFMBT; scm-like with four MBT domains protein
K26585  MBD6; methyl-CpG-binding domain protein 6
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x

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