KEGG ORTHOLOGY: K11456

ORTHOLOGY: K11456

Entry

K11456                      KO

Symbol

PHC1, EDR1

Name

polyhomeotic-like protein 1

Pathway

map03083

Polycomb repressive complex

Disease

H00269

Primary microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K11456  PHC1, EDR1; polyhomeotic-like protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11456  PHC1, EDR1; polyhomeotic-like protein 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Canonical PRC1 (PRC1.2/1.4)
     K11456  PHC1, EDR1; polyhomeotic-like protein 1

Genes

HSA:	1911(PHC1)

PTR:	465374(PHC1)

PPS:	100977709(PHC1)

GGO:	101137296(PHC1)

PON:	100442219(PHC1)

PPYG:

129009425(PHC1)

NLE:	100595053(PHC1)

HMH:	116472647(PHC1)

SSYN:

129483399(PHC1)

MCC:	722268(PHC1)

MCF:	101925136(PHC1)

MTHB:

126931405

MNI:	105499884(PHC1)

CSAB:

103218539(PHC1)

CATY:

105587962(PHC1)

PANU:

101024722 116268489 116272999 116273004

TGE:	112635254(PHC1)

MLEU:

105541977(PHC1)

RRO:	104672840(PHC1)

RBB:	108543674(PHC1)

TFN:	117090782(PHC1)

PTEH:

111526611(PHC1)

CANG:

105519826(PHC1)

CJC:	100408665(PHC1)

SBQ:	101032185(PHC1)

CIMI:

108291863(PHC1)

ANAN:

105721349(PHC1)

CSYR:

103261841(PHC1)

MMUR:

105878275(PHC1)

LCAT:

123640036(PHC1)

PCOQ:

105805076(PHC1)

OGA:	100944861(PHC1)

MMU:	13619(Phc1)

MCAL:

110296682(Phc1)

MPAH:

110316297(Phc1)

RNO:	312690(Phc1)

MCOC:

116099534(Phc1)

ANU:	117714750(Phc1)

ASYL:

127679150(Phc1)

MUN:	110556289(Phc1)

CGE:	100759454(Phc1)

MAUA:

101843279(Phc1)

PROB:

127236225(Phc1)

PLEU:

114683480(Phc1)

MORG:

121434965(Phc1)

MFOT:

126514837

AAMP:

119806712(Phc1)

NGI:	103727466(Phc1)

HGL:	101705028(Phc1)

CPOC:

100728333(Phc1)

CCAN:

109697721(Phc1)

DSP:	122127013(Phc1)

PLOP:

125342822(Phc1)

NCAR:

124982566

MMMA:

107159929(Phc1)

ITI:	101958920(Phc1)

OCU:

100347568

OPI:	101535978(PHC1)

TUP:	102485277(PHC1)

GVR:	103606251(PHC1)

CFA:	610167(PHC1)

CLUD:

112665358(PHC1)

VVP:	112917298(PHC1)

VLG:	121479909(PHC1)

NPO:	129517119(PHC1)

AML:	100472812(PHC1)

UMR:	103669183(PHC1)

UAH:	113257919(PHC1)

UAR:	123781690(PHC1)

ELK:

111141964

LLV:

125107700

MPUF:

101683364(PHC1)

MNP:	132019467(PHC1)

MLK:	131839082(PHC1)

NVS:	122891598(PHC1)

ORO:	101377434(PHC1)

EJU:	114221632(PHC1)

ZCA:	113921818(PHC1)

MLX:	118025691(PHC1)

NSU:	110581055(PHC1)

LWW:	102743529(PHC1)

FCA:	101097991(PHC1)

PYU:	121021927(PHC1)

PBG:	122473214(PHC1)

PVIV:

125169751(PHC1)

LRUF:

124501489

LGF:	123591426(PHC1)

AJU:

106965424

PTG:	102962457(PHC1)

PPAD:

109276154(PHC1)

PUC:

125920072

PLEZ:

122224212(PHC1)

HHV:	120222713(PHC1)

BTA:	540021(PHC1)

BOM:	102269373(PHC1)

BIU:	109559692(PHC1)

BBUB:

102400159(PHC1)

BBIS:

104995498(PHC1)

CHX:	102181278(PHC1)

OAS:	101104987(PHC1)

BTAX:

128047548(PHC1)

CSUM:

138077820(PHC1)

ODA:	120858793(PHC1)

CCAD:

122423252(PHC1)

MREE:

136172344(PHC1)

OVR:	110122405(PHC1)

MBEZ:

129535883(PHC1)

SSC:	100155344(PHC1)

CFR:	102516746(PHC1)

CBAI:

105062182(PHC1)

CDK:	105098236(PHC1)

VPC:	102526167(PHC1)

BACU:

103018750(PHC1)

BMUS:

118901494(PHC1)

LVE:	103078437(PHC1)

OOR:	101271549(PHC1)

LALB:

132529880(PHC1)

DLE:	111176738(PHC1)

PCAD:

102985662(PHC1)

PSIU:

116761006(PHC1)

NASI:

112391752(PHC1)

ECB:	100053465(PHC1)

EPZ:	103542485(PHC1)

EAI:	106837428(PHC1)

MYB:	102242286(PHC1)

MYD:	102775341(PHC1)

MMYO:

118652113(PHC1)

MLF:	102442310(PHC1)

MDT:	132227253(PHC1)

MYUM:

139007356(PHC1)

PKL:	118729846(PHC1)

EFUS:

103285076(PHC1)

MNA:	107544046(PHC1)

DRO:	112321696(PHC1)

SHON:

119002534(PHC1)

AJM:	119065671(PHC1)

PDIC:

114512710(PHC1)

PHAS:

123819348(PHC1)

MMF:	118623586(PHC1)

PPAM:

129085030(PHC1)

HAI:	109372749(PHC1)

RFQ:	117028284(PHC1)

PALE:

102881130(PHC1)

PGIG:

120611697(PHC1)

PVP:	105295913(PHC1)

RAY:	107501664(PHC1)

MJV:	108396115(PHC1)

TOD:	119247733(PHC1)

SARA:

101551392(PHC1)

SFUM:

130042505(PHC1)

SETR:

126006514(PHC1)

LAV:	100658112(PHC1)

TMU:

101348720

ETF:	101646870(PHC1)

DNM:	101418716(PHC1)

MDO:	100012285(PHC1)

GAS:	123250033(PHC1)

SHR:	100932126(PHC1)

AFZ:

127539071

PCW:	110213744(PHC1)

TVP:	118850257(PHC1)

PBRV:

138175640(PHC1)

OAA:	100084213(PHC1)

TACU:

119946599(PHC1)

GGA:	418252(PHC1)

PCOC:

116240938(PHC1)

MGP:	100543084(PHC1)

CJO:	107318409(PHC1)

TPAI:

128089908(PHC1)

LMUT:

125687915(PHC1)

NMEL:

110397829(PHC1)

APLA:

101793378(PHC1)

ACYG:

106048079(PHC1)

CATA:

118247681(PHC1)

AFUL:

116491529(PHC1)

TGU:	100223084(PHC1)

LSR:	110472326(PHC1)

SCAN:

103827206(PHC1)

PMOA:

120497759(PHC1)

OTC:	121341041(PHC1)

PRUF:

121349828(PHC1)

ATRC:

139592763(PHC1)

GFR:	102035642(PHC1)

FAB:	101815695(PHC1)

OMA:	130262046(PHC1)

PHI:	102110853(PHC1)

PMAJ:

107200691(PHC1)

CCAE:

111925706(PHC1)

CCW:	104690272(PHC1)

CBRC:

103616679(PHC1)

ACOE:

138111454(PHC1)

ETL:	114069356(PHC1)

ZAB:	102065724(PHC1)

ZLE:	135451471(PHC1)

ACHL:

103805433(PHC1)

SVG:	106859825(PHC1)

MMEA:

130579183(PHC1)

HRT:	120748630(PHC1)

SATI:

136375606(PHC1)

CCIC:

134041141(PHC1)

FPG:	101912964(PHC1)

FCH:	102055632(PHC1)

CCRI:

104155021

NNT:	104403144(PHC1)

SHAB:

115605819(PHC1)

ACUN:

113491067(PHC1)

TALA:

104357307(PHC1)

ACHC:

115352485(PHC1)

HALD:

104318022(PHC1)

HLE:	104836671(PHC1)

AGEN:

126047835

HHAR:

128143138(PHC1)

GCL:

127016110

CSTI:

104549816(PHC1)

LDI:	104348188(PHC1)

DPUB:

104306891(PHC1)

PPUS:

135175392(PHC1)

AVIT:

104274761(PHC1)

BRHI:

104492583(PHC1)

EGZ:	104122777(PHC1)

NNI:	104014581(PHC1)

PCRI:

104032519(PHC1)

PCAO:

104053277(PHC1)

PADL:

103922186(PHC1)

AFOR:

103899959(PHC1)

FGA:	104083573(PHC1)

GSTE:

104254797

CBOY:

140658991(PHC1)

CLV:	102097235(PHC1)

MUI:	104540129(PHC1)

PGUU:

104466128(PHC1)

PLET:

104624054(PHC1)

EHS:	104503415(PHC1)

CMAC:

104476490

CUCA:

104060627(PHC1)

BREG:

104635146(PHC1)

OHA:	104332467(PHC1)

ACAR:

104525269

CPEA:

104393486(PHC1)

CVF:	104294506(PHC1)

RTD:	128902239(PHC1)

CRID:

134525585(PHC1)

AAM:	106495710(PHC1)

AROW:

112973968(PHC1) 112973988

NPD:	112952036(PHC1)

TGT:

104570734

DNE:	112994446(PHC1)

SCAM:

104152050(PHC1)

ASN:	102374343(PHC1)

AMJ:	102576548(PHC1)

CPOO:

109316230(PHC1)

GGN:	109296601(PHC1)

PSS:	102463302(PHC1)

CMY:	102932636(PHC1)

CCAY:

125623305(PHC1)

DCC:	119860494(PHC1)

CPIC:

101941678(PHC1)

TST:	117884950(PHC1)

CABI:

116823847(PHC1)

MRV:	120404261(PHC1)

ACS:	100564172(phc1)

ASAO:

132767971(PHC1)

PVT:	110090843(PHC1)

SUND:

121921134(PHC1)

PBI:	103049485(PHC1)

PMUR:

107295564(PHC1)

CTIG:

120318648(PHC1)

TSR:	106556031(PHC1)

PGUT:

117656287(PHC1)

APRI:

131190005(PHC1)

PTEX:

113444484(PHC1)

NSS:	113417225(PHC1)

VKO:	123017758(PHC1)

PMUA:

114588042(PHC1)

PRAF:

128405448(PHC1)

ZVI:	118097598(PHC1)

HCG:	128347841(PHC1)

GJA:	107109224(PHC1)

STOW:

125437300(PHC1)

EMC:	129345598(PHC1)

XLA:	108696030(phc1.L) 779336(phc1.S)

XTR:	100488113(phc1)

NPR:	108799451(PHC1)

RTEM:

120946926(PHC1)

BBUF:

121005884(PHC1)

BGAR:

122942294(PHC1)

PWL:	138303654(PHC1)

MUO:	115457687(PHC1)

GSH:	117350016(PHC1)

DRE:	403008(phc1)

SRX:	107714597 107724796

SANH:

107672038 107704919

SGH:	107552845 107587786

CCAR:

109074797 109104866

CAUA:

113116055

CGIB:

127975181 128030577

PTET:

122332237 122360731(phc1)

LROH:

127178946(phc1)

OMC:	131522270(phc1)

PPRM:

120484719(phc1)

RKG:	130090854(phc1)

MAMB:

125243782(phc1)

CIDE:

127497391

CERY:

137033877(phc1)

MASI:

127453277 127453934

TROS:

130557708(phc1)

TDW:	130432614(phc1)

MANU:

129448267(phc1)

PDAB:

135727496 135788872

IPU:	108270321(phc1)

IFU:	128617578(phc1)

PHYP:

113525148

SMEO:

124385000(phc1)

TFD:	113647718(phc1)

TVC:	132846291(phc1)

CGAR:

128520306(phc1)

NGRA:

132886353(phc1)

TRN:	134310862(phc1)

AMEX:

103046610(phc1)

CMAO:

118820392(phc1)

EEE:

113573091

CHAR:

105901654(phc1)

SPIL:

134083066(phc1)

TRU:	101073256 101074676

TFS:	130528045 130532922(phc1)

LCO:	104929021 104939427

NCC:	104960401(phc1) 104962276

TBEN:

117480209(phc1)

CGOB:

115015350 115021725

PGEO:

117455335 117461138(phc1)

GACU:

117543291(phc1) 117545357

EMAC:

134861765(phc1) 134874727

ELY:	117264094 117265249(phc1)

EFO:	125893099(phc1) 125905099

PLEP:

121945233(phc1) 121957737

SLUC:

116046398 116049649(phc1)

ECRA:

117946201(phc1) 117956432

ESP:	116674611 116691219 116701431

PFLV:

114557465 114568448

GAT:	120810810(phc1) 120826984

PPUG:

119197217(phc1) 119218934

AFB:	129096843 129109509(phc1)

CLUM:

117738741 117745436(phc1)

PSWI:

130198278 130213432(phc1)

CANA:

137781083(phc1) 137785193

CVE:	137872936 137891392(phc1)

MSAM:

119897460(phc1) 119907401

SCHU:

122864492 122882014(phc1)

CUD:	121514270(phc1) 121524023

SPUL:

138584039(phc1) 138608877

LMIX:

132983024(phc1) 132991061

ALAT:

119006310(phc1) 119016617

ASTR:

137601911(phc1) 137607716

MZE:	101468789(phc1) 101470784

ONL:	100702739(phc1) 100707304

OAU:	116312018 116323752(phc1)

OLA:	101170870(phc1) 101173875

OML:	112136368 112143645(phc1)

CSAI:

133434404(phc1) 133460753

XMA:	102217249(phc1) 102227439

XCO:	114142012(phc1) 114155946

XHE:	116717487(phc1) 116730743

PRET:

103472849 103478024(phc1)

PFOR:

103136714(phc1) 103146439

PLAI:

106952219 106952579(phc1)

PMEI:

106916571(phc1) 106919762

GAF:	122831037(phc1) 122843457

PPRL:

129371218(phc1) 129375939

CVG:	107082233(phc1) 107089015

CTUL:

119783021(phc1) 119795024

GMU:	124865995(phc1) 124879020

NFU:	107379428(phc1) 107394833

KMR:	108235393(phc1) 108242618

ALIM:

106519598 106520484(phc1)

NWH:	119409322(phc1) 119425906

AOCE:

111568086 111576849(phc1)

EJA:	138194093(phc1) 138209974

BFRE:

138619338(phc1) 138627811

MCEP:

125016811(phc1) 125020475

CSEM:

103387927(phc1) 103393814

POV:	109633243(phc1) 109642623

SSEN:

122774874(phc1) 122786650

SSOE:

131447112 131471222(phc1)

HHIP:

117771041 117776774(phc1)

HSP:	118113170(phc1) 118124583

PPLT:

128449980(phc1) 128462029

SMAU:

118292254 118314760(phc1)

LCF:	108886968 108887333(phc1)

SDU:	111230044(phc1) 111233226

SLAL:

111661221 111669880

XGL:	120784063(phc1) 120786677

HCQ:	109515305(phc1)

SSCV:

125975664(phc1) 125987401

SBIA:

133500692(phc1) 133500947

PEE:	133395516 133401442(phc1)

PTAO:

133470986 133479023(phc1)

BPEC:

110162171 110163076(phc1)

ENY:	140362191 140374055(phc1)

MALB:

109966222 109968889

BSPL:

114842906(phc1) 114866089

SJO:	128365819(phc1)

SSCO:

133982905(phc1) 133996474

GMH:	115536102 115554419(phc1)

SASA:

106569996 106576792 106588438 106605834

STRU:

115173502 115176162 115176392 115188300

OTW:	112225876(phc1) 112229848 112253767 112264832

OMY:	110489262 110496185 110509154 110537299

OGO:	123998119 124004738 124043575

ONE:	115101218 115128346 115131649 115140805

OKI:	109868225 109879284 109903642 109907559

OKE:	118367911 118371226 118398222 118399271

OMM:	135520609 135521896 135552265

OCLA:

139373430 139389408 139392378 139422009

SALP:

111955340 111956105 111958865 111964590

SNH:	120022800 120027287 120031172 120048699

CCLU:

121542953 121572794 121586227 121586420

ELS:	105019051 105025866

OEP:	134007062 134023567(phc1)

SFM:	108924352(phc1)

PKI:	111833971(phc1)

AANG:

118229033(phc1)

AROT:

135240138(phc1)

CCOG:

133127611(phc1)

LOC:

102695042

PSPA:

121296226(phc1) 121325358

ARUT:

117424604 117425178

LCM:	102346970(PHC1)

DME:	Dmel_CG18412(ph-p) Dmel_CG3895(ph-d)

DER:	26526087 6555623

DSE:

6616090

DSI:	Dsimw501_GD24614(Dsim_GD24614)

DYA:	Dyak_GE16977

DSR:	110180128 110180169

DPO:	6901107 6901109

DPE:	113566098 6603207

DMN:	108151703 117186269

DWI:

6648672

DGR:

6566360

DMO:	Dmoj_GI11060

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMRS:

ACOS:

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:	105679350(ph-d)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

AGIF:

CCIN:

TCA:	655591(ph)

TMOL:

DPA:

ESIM:

EFOR:

ATD:

HAXR:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100529124(PH)

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

LGLY:

CSTB:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM396500

FOC:

TPAL:

ZNE:

FCD:

DMK:

LSM:	121122494 121122548 121122621 121122658 121122939

VDE:

VJA:

DPTE:

DFR:

PTEP:

MYI:

LAK:

Reference

PMID:9367423

Authors

Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb MA, Nomura M, Tsuchiya R, Fujita Y, Shibata Y, Higashinakagawa T, Shimada K

Title

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.

Journal

Development 124:3673-82 (1997)

Sequence

[mmu:13619]

LinkDB

DBGET integrated database retrieval system