KEGG   PATHWAY: kph00260
Entry
kph00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae subsp. pneumoniae KPNIH24
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kph00260  Glycine, serine and threonine metabolism
kph00260

Module
kph_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kph00260]
kph_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kph00260]
kph_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kph00260]
kph_M00555  Betaine biosynthesis, choline => betaine [PATH:kph00260]
kph_M00621  Glycine cleavage system [PATH:kph00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae subsp. pneumoniae KPNIH24 [GN:kph]
Gene
KPNIH24_01345  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KPNIH24_03640  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KPNIH24_00445  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
KPNIH24_14710  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH24_24690  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH24_03645  serine kinase [KO:K00872] [EC:2.7.1.39]
KPNIH24_03650  threonine synthase [KO:K01733] [EC:4.2.3.1]
KPNIH24_19850  threonine aldolase [KO:K01620] [EC:4.1.2.48]
KPNIH24_08945  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KPNIH24_18860  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH24_08530  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH24_25280  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KPNIH24_05540  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH24_07770  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH24_15155  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH24_17840  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
KPNIH24_20805  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KPNIH24_03600  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
KPNIH24_25500  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
KPNIH24_23840  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH24_06810  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH24_21440  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH24_19690  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
KPNIH24_03565  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KPNIH24_15750  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KPNIH24_25525  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
KPNIH24_25520  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KPNIH24_16380  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
KPNIH24_06855  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KPNIH24_06845  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
KPNIH24_23810  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH24_04240  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH24_06850  glycine cleavage system protein H [KO:K02437]
KPNIH24_08780  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
KPNIH24_21715  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KPNIH24_21710  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KPNIH24_06205  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KPNIH24_06200  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
KPNIH24_11835  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH24_07715  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH24_00635  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH24_12025  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH24_26125  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
KPNIH24_03295  aldolase [KO:K01753] [EC:4.3.1.18]
KPNIH24_07200  racemase [KO:K25316] [EC:5.1.1.10]
KPNIH24_17835  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KPNIH24_17830  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KPNIH24_14535  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
KPNIH24_14530  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kph00010  Glycolysis / Gluconeogenesis
kph00020  Citrate cycle (TCA cycle)
kph00230  Purine metabolism
kph00250  Alanine, aspartate and glutamate metabolism
kph00270  Cysteine and methionine metabolism
kph00290  Valine, leucine and isoleucine biosynthesis
kph00300  Lysine biosynthesis
kph00330  Arginine and proline metabolism
kph00460  Cyanoamino acid metabolism
kph00470  D-Amino acid metabolism
kph00564  Glycerophospholipid metabolism
kph00600  Sphingolipid metabolism
kph00620  Pyruvate metabolism
kph00630  Glyoxylate and dicarboxylate metabolism
kph00640  Propanoate metabolism
kph00680  Methane metabolism
kph00860  Porphyrin metabolism
kph00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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