KEGG   PATHWAY: kphy00260
Entry
kphy00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Kibdelosporangium phytohabitans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kphy00260  Glycine, serine and threonine metabolism
kphy00260

Module
kphy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kphy00260]
kphy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kphy00260]
kphy_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:kphy00260]
kphy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kphy00260]
kphy_M00555  Betaine biosynthesis, choline => betaine [PATH:kphy00260]
kphy_M00621  Glycine cleavage system [PATH:kphy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kibdelosporangium phytohabitans [GN:kphy]
Gene
AOZ06_01425  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AOZ06_26650  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AOZ06_01430  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AOZ06_46505  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AOZ06_46495  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AOZ06_11780  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOZ06_46500  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOZ06_51805  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AOZ06_41530  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AOZ06_15575  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AOZ06_02105  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AOZ06_46420  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AOZ06_46875  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AOZ06_46860  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AOZ06_50595  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AOZ06_09565  hypothetical protein [KO:K15634] [EC:5.4.2.11]
AOZ06_27725  phosphoglycerate kinase [KO:K15634] [EC:5.4.2.11]
AOZ06_45325  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AOZ06_03255  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AOZ06_09700  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AOZ06_40085  hydrolase [KO:K01079] [EC:3.1.3.3]
AOZ06_11020  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AOZ06_09545  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
AOZ06_09540  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AOZ06_32880  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AOZ06_13380  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AOZ06_13360  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AOZ06_09525  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AOZ06_32905  hypothetical protein [KO:K02437]
AOZ06_16915  amidinotransferase [KO:K00613] [EC:2.1.4.1]
AOZ06_02710  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
AOZ06_00340  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AOZ06_14715  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOZ06_34125  phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOZ06_36600  phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOZ06_00305  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
AOZ06_00290  ferredoxin [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AOZ06_00300  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AOZ06_00285  hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AOZ06_00295  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AOZ06_46630  hypothetical protein [KO:K18896] [EC:2.1.1.156]
AOZ06_06205  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AOZ06_29815  cysteine synthase [KO:K01697] [EC:4.2.1.22]
AOZ06_45210  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
AOZ06_15580  serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AOZ06_19460  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AOZ06_19600  hypothetical protein [KO:K01754] [EC:4.3.1.19]
AOZ06_24155  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AOZ06_48700  hypothetical protein [KO:K01754] [EC:4.3.1.19]
AOZ06_38230  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AOZ06_30830  racemase [KO:K25316] [EC:5.1.1.10]
AOZ06_22115  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AOZ06_21680  hypothetical protein [KO:K01695] [EC:4.2.1.20]
AOZ06_43335  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AOZ06_42070  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AOZ06_21685  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AOZ06_43340  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AOZ06_22095  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
AOZ06_21745  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
AOZ06_02515  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AOZ06_26640  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
AOZ06_02510  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
AOZ06_22110  ectoine synthase [KO:K06720] [EC:4.2.1.108]
AOZ06_21730  ectoine synthase [KO:K06720] [EC:4.2.1.108]
AOZ06_02520  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
AOZ06_42065  ectoine synthase [KO:K06720] [EC:4.2.1.108]
AOZ06_02525  multidrug DMT transporter permease [KO:K10674] [EC:1.14.11.55]
AOZ06_15130  hypothetical protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kphy00010  Glycolysis / Gluconeogenesis
kphy00020  Citrate cycle (TCA cycle)
kphy00230  Purine metabolism
kphy00250  Alanine, aspartate and glutamate metabolism
kphy00270  Cysteine and methionine metabolism
kphy00290  Valine, leucine and isoleucine biosynthesis
kphy00300  Lysine biosynthesis
kphy00330  Arginine and proline metabolism
kphy00460  Cyanoamino acid metabolism
kphy00470  D-Amino acid metabolism
kphy00564  Glycerophospholipid metabolism
kphy00600  Sphingolipid metabolism
kphy00620  Pyruvate metabolism
kphy00630  Glyoxylate and dicarboxylate metabolism
kphy00640  Propanoate metabolism
kphy00680  Methane metabolism
kphy00860  Porphyrin metabolism
kphy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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