KEGG   PATHWAY: kpv00260
Entry
kpv00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae subsp. pneumoniae KPNIH29
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kpv00260  Glycine, serine and threonine metabolism
kpv00260

Module
kpv_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpv00260]
kpv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kpv00260]
kpv_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpv00260]
kpv_M00555  Betaine biosynthesis, choline => betaine [PATH:kpv00260]
kpv_M00621  Glycine cleavage system [PATH:kpv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae subsp. pneumoniae KPNIH29 [GN:kpv]
Gene
KPNIH29_01310  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KPNIH29_03860  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KPNIH29_00420  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
KPNIH29_24520  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH29_13695  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH29_03865  serine kinase [KO:K00872] [EC:2.7.1.39]
KPNIH29_03870  threonine synthase [KO:K01733] [EC:4.2.3.1]
KPNIH29_08920  threonine aldolase [KO:K01620] [EC:4.1.2.48]
KPNIH29_19750  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KPNIH29_20330  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH29_09655  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH29_25130  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KPNIH29_21120  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH29_23205  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH29_13230  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH29_08180  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KPNIH29_03815  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
KPNIH29_25330  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
KPNIH29_07530  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH29_22215  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH29_09095  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
KPNIH29_03780  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KPNIH29_12670  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KPNIH29_25355  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
KPNIH29_25350  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KPNIH29_11765  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
KPNIH29_22170  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KPNIH29_22180  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
KPNIH29_04440  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH29_22175  glycine cleavage system protein H [KO:K02437]
KPNIH29_19920  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
KPNIH29_07250  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KPNIH29_07255  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KPNIH29_22525  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KPNIH29_22530  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
KPNIH29_16630  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH29_21175  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH29_16430  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH29_00610  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH29_26075  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
KPNIH29_03490  aldolase [KO:K01753] [EC:4.3.1.18]
KPNIH29_21705  racemase [KO:K25316] [EC:5.1.1.10]
KPNIH29_10995  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KPNIH29_11000  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KPNIH29_13850  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
KPNIH29_13855  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kpv00010  Glycolysis / Gluconeogenesis
kpv00020  Citrate cycle (TCA cycle)
kpv00230  Purine metabolism
kpv00250  Alanine, aspartate and glutamate metabolism
kpv00270  Cysteine and methionine metabolism
kpv00290  Valine, leucine and isoleucine biosynthesis
kpv00300  Lysine biosynthesis
kpv00330  Arginine and proline metabolism
kpv00460  Cyanoamino acid metabolism
kpv00470  D-Amino acid metabolism
kpv00564  Glycerophospholipid metabolism
kpv00600  Sphingolipid metabolism
kpv00620  Pyruvate metabolism
kpv00630  Glyoxylate and dicarboxylate metabolism
kpv00640  Propanoate metabolism
kpv00680  Methane metabolism
kpv00860  Porphyrin metabolism
kpv00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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