KEGG   PATHWAY: kpw00260
Entry
kpw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae subsp. pneumoniae KPNIH30
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kpw00260  Glycine, serine and threonine metabolism
kpw00260

Module
kpw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpw00260]
kpw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kpw00260]
kpw_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpw00260]
kpw_M00555  Betaine biosynthesis, choline => betaine [PATH:kpw00260]
kpw_M00621  Glycine cleavage system [PATH:kpw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae subsp. pneumoniae KPNIH30 [GN:kpw]
Gene
KPNIH30_01375  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KPNIH30_03820  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KPNIH30_00455  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
KPNIH30_14005  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH30_24970  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KPNIH30_03825  serine kinase [KO:K00872] [EC:2.7.1.39]
KPNIH30_03830  threonine synthase [KO:K01733] [EC:4.2.3.1]
KPNIH30_09175  threonine aldolase [KO:K01620] [EC:4.1.2.48]
KPNIH30_19935  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KPNIH30_10175  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH30_20340  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KPNIH30_25590  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KPNIH30_21140  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH30_23530  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH30_13560  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KPNIH30_11255  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
KPNIH30_08215  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KPNIH30_03775  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
KPNIH30_25805  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
KPNIH30_07560  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH30_05220  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH30_22220  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KPNIH30_09345  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
KPNIH30_03740  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KPNIH30_12955  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KPNIH30_25830  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
KPNIH30_25825  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KPNIH30_12305  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
KPNIH30_22175  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KPNIH30_22185  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
KPNIH30_04455  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KPNIH30_22180  glycine cleavage system protein H [KO:K02437]
KPNIH30_20105  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
KPNIH30_07285  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KPNIH30_07290  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KPNIH30_22845  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KPNIH30_22850  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
KPNIH30_16945  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH30_21195  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KPNIH30_16750  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH30_00645  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KPNIH30_26470  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
KPNIH30_03450  aldolase [KO:K01753] [EC:4.3.1.18]
KPNIH30_21725  racemase [KO:K25316] [EC:5.1.1.10]
KPNIH30_11260  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KPNIH30_11265  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KPNIH30_14195  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
KPNIH30_14200  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kpw00010  Glycolysis / Gluconeogenesis
kpw00020  Citrate cycle (TCA cycle)
kpw00230  Purine metabolism
kpw00250  Alanine, aspartate and glutamate metabolism
kpw00270  Cysteine and methionine metabolism
kpw00290  Valine, leucine and isoleucine biosynthesis
kpw00300  Lysine biosynthesis
kpw00330  Arginine and proline metabolism
kpw00460  Cyanoamino acid metabolism
kpw00470  D-Amino acid metabolism
kpw00564  Glycerophospholipid metabolism
kpw00600  Sphingolipid metabolism
kpw00620  Pyruvate metabolism
kpw00630  Glyoxylate and dicarboxylate metabolism
kpw00640  Propanoate metabolism
kpw00680  Methane metabolism
kpw00860  Porphyrin metabolism
kpw00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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