KEGG   PATHWAY: mcf04612
Entry
mcf04612                    Pathway                                
Name
Antigen processing and presentation - Macaca fascicularis (crab-eating macaque)
Class
Organismal Systems; Immune system
Pathway map
mcf04612  Antigen processing and presentation
mcf04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864991  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101865017  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101865828  NFYC; nuclear transcription factor Y subunit gamma isoform X3 [KO:K08066]
101866363  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
101866865  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101867173  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
101867471  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101925077  CANX; calnexin isoform X1 [KO:K08054]
101925240  [KO:K03283]
101926012  HSPA1L; heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
101926380  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102114867  [KO:K07980]
102115251  [KO:K07980]
102115630  KIR2DL4; killer cell immunoglobulin-like receptor 2DL4 [KO:K24231]
102116527  [KO:K06751]
102116556  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102116611  [KO:K07980]
102116937  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102117143  [KO:K06751]
102119829  KLRD1; natural killer cells antigen CD94 isoform X1 [KO:K06516]
102120132  Mafa; class I histocompatibility antigen, Gogo-B*0101 alpha chain precursor [KO:K06751]
102120587  [KO:K07980]
102120796  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
102121106  KLRC1; NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
102121336  CALR; calreticulin [KO:K08057]
102122138  MAFA-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
102122433  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X5 [KO:K06459]
102122509  KLRC4; NKG2-F type II integral membrane protein [KO:K24233]
102123548  Mafa-B; class I histocompatibility antigen, Gogo-B*0103 alpha chain precursor [KO:K06751]
102124337  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
102124831  TAPBP; tapasin isoform X1 [KO:K08058]
102128291  IFNG; interferon gamma [KO:K04687]
102129555  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102131294  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102131412  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
102132662  [KO:K06752]
102133044  [KO:K06752]
102134814  NFYA; nuclear transcription factor Y subunit alpha isoform X4 [KO:K08064]
102136468  [KO:K06752]
102136503  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
102136862  [KO:K06752]
102137481  Mafa-DOA; HLA class II histocompatibility antigen, DO alpha chain isoform 1 precursor [KO:K06752]
102138204  RFXAP; regulatory factor X-associated protein isoform X1 [KO:K08063]
102138874  Mafa-E; popy class I histocompatibility antigen, alpha chain E isoform 1 precursor [KO:K06751]
102139597  RFXANK; DNA-binding protein RFXANK isoform X17 [KO:K08062]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139994  Mafa-DMA; HLA class II histocompatibility antigen, DM alpha chain isoform 1 precursor [KO:K06752]
102140002  [KO:K06751]
102140649  Mafa-DMB; HLA class II histocompatibility antigen, DM beta chain precursor [KO:K06752]
102140826  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102141082  PSME1; proteasome activator complex subunit 1 isoform X1 [KO:K06696]
102141835  [KO:K06751]
102141952  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
102142346  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102143176  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102143196  PSME3; proteasome activator complex subunit 3 isoform X2 [KO:K06698]
102143391  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102144039  DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
102144095  PSME2; proteasome activator complex subunit 2 isoform X1 [KO:K06697]
102144257  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
102144414  [KO:K06752]
102144764  [KO:K07980]
102145413  Mafa-DOB; HLA class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
102146944  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
123570251  [KO:K07980]
123570290  [KO:K07980]
123570291  [KO:K07980]
123570293  [KO:K07980]
123572795  [KO:K03283]
123572909  [KO:K06752]
123572910  [KO:K06752]
135964326  [KO:K06751]
135964331  [KO:K24233]
135964412  [KO:K24233]
135966154  [KO:K24233]
135970329  [KO:K06751]
135970331  [KO:K06751]
135970333  [KO:K06751]
135970336  [KO:K06751]
135970341  [KO:K06751]
135970343  [KO:K06751]
135970345  [KO:K06751]
135970471  [KO:K06752]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
mcf03050  Proteasome
mcf04650  Natural killer cell mediated cytotoxicity
mcf04660  T cell receptor signaling pathway
KO pathway
ko04612   

DBGET integrated database retrieval system