KEGG   PATHWAY: mhev00230
Entry
mhev00230                   Pathway                                
Name
Purine metabolism - Mycolicibacterium helvum
Class
Metabolism; Nucleotide metabolism
Pathway map
mhev00230  Purine metabolism
mhev00230

Module
mhev_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mhev00230]
mhev_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mhev00230]
mhev_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mhev00230]
mhev_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mhev00230]
mhev_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mhev00230]
mhev_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mhev00230]
Other DBs
GO: 0006163 0042278
Organism
Mycolicibacterium helvum [GN:mhev]
Gene
MHEL_00860  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
MHEL_02060  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MHEL_03950  [KO:K00926] [EC:2.7.2.2]
MHEL_06070  rdgB; non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
MHEL_07330  cysNC; adenylyl-sulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MHEL_07340  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
MHEL_07560  [KO:K01768] [EC:4.6.1.1]
MHEL_09660  [KO:K01768] [EC:4.6.1.1]
MHEL_11430  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
MHEL_14630  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MHEL_16260  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
MHEL_16340  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
MHEL_17660  [KO:K00957] [EC:2.7.7.4]
MHEL_17670  [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MHEL_21130  [KO:K01768] [EC:4.6.1.1]
MHEL_26850  [KO:K01768] [EC:4.6.1.1]
MHEL_27000  [KO:K16841] [EC:5.1.99.3]
MHEL_27010  [KO:K16842] [EC:3.5.2.5]
MHEL_27020  alc_1; putative allantoicase [KO:K01477] [EC:3.5.3.4]
MHEL_27050  [KO:K16840] [EC:4.1.1.97]
MHEL_27100  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MHEL_28990  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MHEL_29060  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MHEL_29110  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MHEL_29200  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264]
MHEL_29210  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265]
MHEL_29260  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269]
MHEL_29320  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
MHEL_29360  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MHEL_32320  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MHEL_32330  purH; bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MHEL_33420  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MHEL_33470  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MHEL_33550  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MHEL_34530  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
MHEL_34540  [KO:K00088] [EC:1.1.1.205]
MHEL_34690  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
MHEL_34730  [KO:K01239] [EC:3.2.2.1]
MHEL_35260  ggt; gamma-glutamyltranspeptidase [KO:K22602] [EC:3.5.1.126]
MHEL_35410  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
MHEL_35530  punA; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MHEL_36120  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
MHEL_36130  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
MHEL_40220  pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
MHEL_40740  [KO:K00926] [EC:2.7.2.2]
MHEL_41580  nrdE; ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MHEL_41710  nrdF2; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
MHEL_43330  [KO:K02566] [EC:3.1.3.5]
MHEL_46470  [KO:K19710] [EC:2.7.7.53]
MHEL_46830  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MHEL_46840  relA; GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MHEL_47910  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
MHEL_53280  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MHEL_53290  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
MHEL_53300  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
MHEL_53360  guaB1; putative oxidoreductase [KO:K26110]
MHEL_53780  alc_2; putative allantoicase [KO:K01477] [EC:3.5.3.4]
MHEL_53790  [KO:K16841] [EC:5.1.99.3]
MHEL_53800  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
MHEL_55360  [KO:K11178] [EC:1.17.1.4]
MHEL_55370  [KO:K13483]
MHEL_55380  [KO:K11177] [EC:1.17.1.4]
MHEL_56070  cya; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MHEL_58340  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MHEL_58870  [KO:K00856] [EC:2.7.1.20]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mhev00030  Pentose phosphate pathway
mhev00220  Arginine biosynthesis
mhev00250  Alanine, aspartate and glutamate metabolism
mhev00260  Glycine, serine and threonine metabolism
mhev00340  Histidine metabolism
mhev00630  Glyoxylate and dicarboxylate metabolism
mhev00730  Thiamine metabolism
mhev00740  Riboflavin metabolism
mhev00790  Folate biosynthesis
KO pathway
ko00230   

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