KEGG   PATHWAY: mhev00630
Entry
mhev00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycolicibacterium helvum
Class
Metabolism; Carbohydrate metabolism
Pathway map
mhev00630  Glyoxylate and dicarboxylate metabolism
mhev00630

Module
mhev_M00621  Glycine cleavage system [PATH:mhev00630]
mhev_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mhev00630]
Other DBs
GO: 0046487 0043648
Organism
Mycolicibacterium helvum [GN:mhev]
Gene
MHEL_00460  glnA4; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MHEL_00540  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
MHEL_02300  [KO:K01816] [EC:5.3.1.22]
MHEL_02500  glnN; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MHEL_04240  glcD; oxidoreductase [KO:K00104] [EC:1.1.99.14]
MHEL_05320  [KO:K00626] [EC:2.3.1.9]
MHEL_05820  [KO:K01849] [EC:5.4.99.2]
MHEL_05830  [KO:K01848] [EC:5.4.99.2]
MHEL_06220  [KO:K01895] [EC:6.2.1.1]
MHEL_06340  [KO:K00626] [EC:2.3.1.9]
MHEL_06350  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
MHEL_07660  [KO:K00104] [EC:1.1.99.14]
MHEL_07980  kgd; multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MHEL_09300  [KO:K00626] [EC:2.3.1.9]
MHEL_09770  [KO:K01625] [EC:4.1.2.14 4.1.3.42]
MHEL_10230  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MHEL_10460  [KO:K00626] [EC:2.3.1.9]
MHEL_14960  aceA_1; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MHEL_15020  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MHEL_18630  [KO:K00626] [EC:2.3.1.9]
MHEL_25450  frc; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
MHEL_25460  [KO:K01577] [EC:4.1.1.8]
MHEL_25970  glnT; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MHEL_26050  [KO:K03781] [EC:1.11.1.6]
MHEL_26690  [KO:K01895] [EC:6.2.1.1]
MHEL_28360  [KO:K00626] [EC:2.3.1.9]
MHEL_29730  [KO:K00626] [EC:2.3.1.9]
MHEL_29860  [KO:K00626] [EC:2.3.1.9]
MHEL_30320  [KO:K00626] [EC:2.3.1.9]
MHEL_30720  [KO:K01647] [EC:2.3.3.1]
MHEL_30770  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
MHEL_31260  [KO:K00626] [EC:2.3.1.9]
MHEL_32020  [KO:K00626] [EC:2.3.1.9]
MHEL_32050  pdhD; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MHEL_35320  [KO:K00626] [EC:2.3.1.9]
MHEL_35860  [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
MHEL_35910  [KO:K27095]
MHEL_35920  [KO:K27094]
MHEL_36550  [KO:K01915] [EC:6.3.1.2]
MHEL_37470  glnA4-1; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MHEL_37600  [KO:K01915] [EC:6.3.1.2]
MHEL_37880  gcvP_1; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MHEL_37890  gcvT_1; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MHEL_37900  gcvH_1; glycine cleavage system H protein [KO:K02437]
MHEL_37910  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
MHEL_38130  gltA1; citrate synthase [KO:K01659] [EC:2.3.3.5]
MHEL_42580  [KO:K01915] [EC:6.3.1.2]
MHEL_43530  [KO:K00626] [EC:2.3.1.9]
MHEL_43550  [KO:K00626] [EC:2.3.1.9]
MHEL_44310  [KO:K01915] [EC:6.3.1.2]
MHEL_46930  [KO:K03781] [EC:1.11.1.6]
MHEL_48870  acnA; aconitate hydratase A [KO:K27802]
MHEL_49010  mutA; methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
MHEL_49020  [KO:K01847] [EC:5.4.99.2]
MHEL_50810  [KO:K00104] [EC:1.1.99.14]
MHEL_52800  glnA3; glutamine synthetase GlnA [KO:K01915] [EC:6.3.1.2]
MHEL_53030  [KO:K00626] [EC:2.3.1.9]
MHEL_53400  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
MHEL_53430  gcvP_2; putative glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MHEL_53480  gcvH_2; glycine cleavage system H protein [KO:K02437]
MHEL_54160  aceA_2; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MHEL_54620  [KO:K01569] [EC:4.1.1.2]
MHEL_57270  [KO:K01915] [EC:6.3.1.2]
MHEL_57280  [KO:K01915] [EC:6.3.1.2]
MHEL_58900  [KO:K00865] [EC:2.7.1.165]
MHEL_58960  gcvT_2; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MHEL_59230  glnA_1; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
MHEL_59300  glnA_2; putative glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
MHEL_59550  [KO:K01091] [EC:3.1.3.18]
MHEL_60270  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mhev00010  Glycolysis / Gluconeogenesis
mhev00020  Citrate cycle (TCA cycle)
mhev00030  Pentose phosphate pathway
mhev00053  Ascorbate and aldarate metabolism
mhev00071  Fatty acid degradation
mhev00230  Purine metabolism
mhev00250  Alanine, aspartate and glutamate metabolism
mhev00260  Glycine, serine and threonine metabolism
mhev00270  Cysteine and methionine metabolism
mhev00620  Pyruvate metabolism
mhev00710  Carbon fixation by Calvin cycle
mhev00750  Vitamin B6 metabolism
mhev00910  Nitrogen metabolism
KO pathway
ko00630   

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