KEGG   PATHWAY: mich00230
Entry
mich00230                   Pathway                                
Name
Purine metabolism - Micromonospora sp. HM134
Class
Metabolism; Nucleotide metabolism
Pathway map
mich00230  Purine metabolism
mich00230

Module
mich_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mich00230]
mich_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mich00230]
mich_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mich00230]
mich_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mich00230]
mich_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mich00230]
Other DBs
GO: 0006163 0042278
Organism
Micromonospora sp. HM134 [GN:mich]
Gene
FJK98_09885  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
FJK98_27515  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
FJK98_04080  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
FJK98_00990  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
FJK98_00865  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
FJK98_28240  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
FJK98_00970  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
FJK98_00960  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
FJK98_00965  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
FJK98_00995  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
FJK98_04975  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
FJK98_04980  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
FJK98_27665  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
FJK98_00945  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
FJK98_28235  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
FJK98_10730  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
FJK98_00500  phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
FJK98_28295  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
FJK98_22700  HAD family hydrolase [KO:K02566] [EC:3.1.3.5]
FJK98_31115  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
FJK98_30580  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
FJK98_28400  GuaB3 family IMP dehydrogenase-related protein [KO:K00088] [EC:1.1.1.205]
FJK98_28405  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
FJK98_25910  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
FJK98_05920  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
FJK98_28380  guaA; glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
FJK98_04435  GuaB1 family IMP dehydrogenase-related protein [KO:K26110] [EC:1.7.1.7]
FJK98_10975  guanylate kinase [KO:K00942] [EC:2.7.4.8]
FJK98_13740  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
FJK98_08225  vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
FJK98_12975  hypothetical protein [KO:K00526] [EC:1.17.4.1]
FJK98_13735  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
FJK98_25470  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
FJK98_10005  dgt; dNTP triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
FJK98_10735  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
FJK98_24180  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
FJK98_29525  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
FJK98_04780  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
FJK98_31755  cyaB; class IV adenylate cyclase [KO:K05873] [EC:4.6.1.1]
FJK98_00900  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
FJK98_00855  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
FJK98_24280  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
FJK98_04230  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
FJK98_17460  bifunctional metallophosphatase/5'-nucleotidase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
FJK98_28800  adenylate kinase [KO:K00939] [EC:2.7.4.3]
FJK98_10565  HIT domain-containing protein [KO:K19710] [EC:2.7.7.53]
FJK98_14045  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
FJK98_04105  cysN; sulfate adenylyltransferase subunit CysN [KO:K00956] [EC:2.7.7.4]
FJK98_14585  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
FJK98_14040  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
FJK98_14590  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
FJK98_04100  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
FJK98_28175  cysC; adenylyl-sulfate kinase [KO:K00958] [EC:2.7.7.4]
FJK98_18765  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
FJK98_18770  urease subunit beta [KO:K01429] [EC:3.5.1.5]
FJK98_18775  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mich00030  Pentose phosphate pathway
mich00220  Arginine biosynthesis
mich00250  Alanine, aspartate and glutamate metabolism
mich00260  Glycine, serine and threonine metabolism
mich00340  Histidine metabolism
mich00630  Glyoxylate and dicarboxylate metabolism
mich00730  Thiamine metabolism
mich00740  Riboflavin metabolism
mich00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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