KEGG   PATHWAY: mlx03013
Entry
mlx03013                    Pathway                                
Name
Nucleocytoplasmic transport - Mirounga leonina (Southern elephant seal)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mlx03013  Nucleocytoplasmic transport
mlx03013

Other DBs
GO: 0050658
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117997442  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
117998289  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
117998577  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
117998637  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
117998817  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
117998978  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
117999362  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
117999481  [KO:K14316]
117999668  XPO6; exportin-6 isoform X1 [KO:K25204]
117999752  [KO:K12160]
117999946  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
118000270  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
118000596  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
118001055  NUP43; nucleoporin Nup43 [KO:K14305]
118001179  XPO5; exportin-5 isoform X1 [KO:K14289]
118001505  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
118001547  [KO:K03231]
118002423  PNN; pinin [KO:K13114]
118003084  SNUPN; snurportin-1 isoform X1 [KO:K13151]
118003375  IPO4; importin-4 isoform X1 [KO:K20221]
118003463  ACIN1; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
118004080  [KO:K14325]
118004198  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
118004272  IPO7; importin-7 isoform X1 [KO:K20223]
118004633  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
118004918  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
118005094  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
118005155  [KO:K12160]
118005640  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
118005791  TNPO2; transportin-2 isoform X1 [KO:K18727]
118005834  [KO:K12160]
118005883  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
118005963  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
118006015  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
118006340  [KO:K14312]
118006467  [KO:K14312]
118006661  [KO:K12160]
118006795  [KO:K12160]
118006914  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
118006970  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
118007034  KPNA1; importin subunit alpha-5 [KO:K23940]
118008081  XPO1; exportin-1 isoform X1 [KO:K14290]
118008296  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
118008594  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
118008626  XPOT; exportin-T [KO:K14288]
118008737  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
118008793  AAAS; aladin isoform X1 [KO:K14320]
118009206  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
118009281  IPO5; importin-5 [KO:K20222]
118009456  KPNA3; importin subunit alpha-4 [KO:K23583]
118009574  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
118009594  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
118009597  XPO4; exportin-4 isoform X1 [KO:K25203]
118010189  [KO:K14324]
118010196  [KO:K12160]
118010431  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
118010578  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
118010641  [KO:K12160]
118010718  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
118011179  NXT1; NTF2-related export protein 1 [KO:K14285]
118011278  [KO:K12160]
118011300  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
118011678  [KO:K15043]
118012009  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
118012140  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
118012244  NUP35; nucleoporin NUP35 [KO:K14313]
118012405  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
118012547  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
118012884  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
118013838  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
118014205  IPO9; importin-9 isoform X1 [KO:K20224]
118014404  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
118014574  AHCTF1; protein ELYS isoform X1 [KO:K25129]
118015064  [KO:K12160]
118015358  [KO:K12160]
118015849  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
118015957  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118016585  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
118016636  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
118016826  IPO11; importin-11 isoform X1 [KO:K25201]
118016890  TNPO1; transportin-1 isoform X1 [KO:K18752]
118016930  THOC3; THO complex subunit 3 [KO:K12880]
118017143  [KO:K07936]
118017576  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
118017605  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
118017828  [KO:K14324]
118017918  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
118018364  RAN; GTP-binding nuclear protein Ran [KO:K07936]
118018461  [KO:K12160]
118018629  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
118019391  NDC1; nucleoporin NDC1 [KO:K14315]
118019398  MAGOH; protein mago nashi homolog [KO:K12877]
118019517  IPO13; importin-13 [KO:K25202]
118019759  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
118019872  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
118019890  [KO:K03231]
118020863  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
118021066  TNPO3; transportin-3 isoform X1 [KO:K15436]
118021124  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
118021319  [KO:K12160]
118021588  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
118021684  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
118021726  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
118021746  THOC6; THO complex subunit 6 homolog [KO:K13175]
118021962  [KO:K15043]
118022066  XPO7; exportin-7 isoform X1 [KO:K18460]
118022376  [KO:K07936]
118023582  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
118023760  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
118023946  CSE1L; exportin-2 [KO:K18423]
118023992  RAE1; mRNA export factor [KO:K14298]
118024048  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
118024124  [KO:K12160]
118024161  ALYREF; THO complex subunit 4 [KO:K12881]
118024196  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
118024275  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
118024279  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
118024361  KPNA2; importin subunit alpha-1 [KO:K15043]
118024483  [KO:K12160]
118024821  KPNB1; importin subunit beta-1 [KO:K14293]
118024858  CASC3; protein CASC3 isoform X1 [KO:K14323]
118025535  IPO8; importin-8 [KO:K18755]
118025667  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
118026713  [KO:K14324]
118026951  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
118027237  POM121L2; POM121-like protein 2 [KO:K14316]
118027277  [KO:K15043]
118027348  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mlx03015  mRNA surveillance pathway
KO pathway
ko03013   

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