KEGG   PATHWAY: mphl00630
Entry
mphl00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycolicibacterium phlei
Class
Metabolism; Carbohydrate metabolism
Pathway map
mphl00630  Glyoxylate and dicarboxylate metabolism
mphl00630

Module
mphl_M00012  Glyoxylate cycle [PATH:mphl00630]
mphl_M00621  Glycine cleavage system [PATH:mphl00630]
mphl_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mphl00630]
Other DBs
GO: 0046487 0043648
Organism
Mycolicibacterium phlei [GN:mphl]
Gene
MPHLCCUG_04545  icl; Isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MPHLCCUG_02488  aceA; Isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MPHLCCUG_00402  acsA_1; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MPHLCCUG_02499  acsA_3; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MPHLCCUG_02361  glcB; Malate synthase G [KO:K01638] [EC:2.3.3.9]
MPHLCCUG_04022  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
MPHLCCUG_00807  citA; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
MPHLCCUG_00811  gltA2; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
MPHLCCUG_00550  prpC2; 2-methylcitrate synthase 2 [KO:K01659] [EC:2.3.3.5]
MPHLCCUG_02871  acnA; Aconitate hydratase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
MPHLCCUG_01917  fadI_1; 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00864  pcaF_2; Beta-ketoadipyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00937  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_04267  fadA_7; 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_01888  thlA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_04860  fadI_3; 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00516  pcaF_1; Beta-ketoadipyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00533  fadA_1; Putative acyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00771  fadA_2; Putative acyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_00586  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_02391  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_03898  putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MPHLCCUG_03899  Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein [KO:K05606] [EC:5.1.99.1]
MPHLCCUG_01582  accA1_2; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
MPHLCCUG_01592  accD5_3; putative propionyl-CoA carboxylase beta chain 5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
MPHLCCUG_01591  hypothetical protein [KO:K27095]
MPHLCCUG_03394  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MPHLCCUG_02855  mutB; Methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
MPHLCCUG_02856  mutA; Methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
MPHLCCUG_03825  scpA_2; Methylmalonyl-CoA mutase [KO:K01849] [EC:5.4.99.2]
MPHLCCUG_03826  scpA_3; Methylmalonyl-CoA mutase [KO:K01848] [EC:5.4.99.2]
MPHLCCUG_05088  putative FAD-linked oxidoreductase [KO:K00104] [EC:1.1.99.14]
MPHLCCUG_05089  putative FAD-linked oxidoreductase [KO:K00104] [EC:1.1.99.14]
MPHLCCUG_04004  putative FAD-linked oxidoreductase [KO:K00104] [EC:1.1.99.14]
MPHLCCUG_00345  katA; Catalase [KO:K03781] [EC:1.11.1.6]
MPHLCCUG_03375  5'-nucleotidase [KO:K01091] [EC:3.1.3.18]
MPHLCCUG_02419  glnA_3; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_02429  puuA; Gamma-glutamylputrescine synthetase PuuA [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_00335  glnT_1; Glutamine synthetase 3 [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_01103  glnA_1; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_02220  glnA_2; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_03353  glnA_4; Glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_03359  glnA_5; putative glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
MPHLCCUG_04246  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MPHLCCUG_02358  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MPHLCCUG_02554  gcvT_2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MPHLCCUG_03342  gcvT_3; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MPHLCCUG_04550  lpdC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MPHLCCUG_02353  gcvH; Glycine cleavage system H protein [KO:K02437]
MPHLCCUG_02169  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
MPHLCCUG_04016  kgd; Multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MPHLCCUG_01971  oxdC; Oxalate decarboxylase OxdC [KO:K01569] [EC:4.1.1.2]
MPHLCCUG_01884  purU; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
MPHLCCUG_01442  amdA; Acetamidase [KO:K01455] [EC:3.5.1.49]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mphl00010  Glycolysis / Gluconeogenesis
mphl00020  Citrate cycle (TCA cycle)
mphl00030  Pentose phosphate pathway
mphl00053  Ascorbate and aldarate metabolism
mphl00071  Fatty acid degradation
mphl00230  Purine metabolism
mphl00250  Alanine, aspartate and glutamate metabolism
mphl00260  Glycine, serine and threonine metabolism
mphl00620  Pyruvate metabolism
mphl00710  Carbon fixation by Calvin cycle
mphl00750  Vitamin B6 metabolism
mphl00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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