KEGG   PATHWAY: mpuf04612
Entry
mpuf04612                   Pathway                                
Name
Antigen processing and presentation - Mustela putorius furo (domestic ferret)
Class
Organismal Systems; Immune system
Pathway map
mpuf04612  Antigen processing and presentation
mpuf04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101693741  IFNG; interferon gamma [KO:K04687]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101690559  PSME1; proteasome activator complex subunit 1 [KO:K06696]
101687987  PSME2; proteasome activator complex subunit 2 isoform X4 [KO:K06697]
101678225  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
101687880  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101669926  heat shock 70 kDa protein 1 [KO:K03283]
101670246  heat shock 70 kDa protein 1-like [KO:K03283]
101670543  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101679010  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101680741  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101685026  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101676800  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101690116  heat shock protein HSP 90-alpha-like [KO:K04079]
101693321  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
101693860  HLA class I histocompatibility antigen, A-34 alpha chain-like [KO:K06751]
106004724  HLA class I histocompatibility antigen, Cw-8 alpha chain-like [KO:K06751]
101689041  HLA class I histocompatibility antigen, A-80 alpha chain-like isoform X1 [KO:K06751]
101690568  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
101693461  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101681931  CANX; calnexin [KO:K08054]
101673939  B2M; beta-2-microglobulin [KO:K08055]
101670116  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101676085  CALR; calreticulin [KO:K08057]
101683633  TAPBP; tapasin [KO:K08058]
101674199  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
101685563  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
101686033  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
101690739  uncharacterized protein LOC101690739 [KO:K10784]
101686008  uncharacterized protein LOC101686008 [KO:K10785]
106003331  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
101691874  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
101692160  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101692453  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
101692724  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101682407  NKG2-C type II integral membrane protein-like isoform X1 [KO:K06541]
101690095  KLRD1; natural killer cells antigen CD94 isoform X1 [KO:K06516]
101679893  IFI30; LOW QUALITY PROTEIN: gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
101683297  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101694438  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101691795  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101692125  RLA class II histocompatibility antigen, DP beta chain [KO:K06752]
101673877  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
101674777  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
106003441  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101675687  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
101682907  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
101670362  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101683191  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
101683501  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101677272  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101690706  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101671551  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101678035  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
101678178  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
101684722  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101681737  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
101673105  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101674158  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101687698  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
101683261  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
101684487  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
101684223  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
101692714  RFX5; DNA-binding protein RFX5 isoform X3 [KO:K08061]
101684457  RFXANK; DNA-binding protein RFXANK [KO:K08062]
101691297  RFXAP; regulatory factor X-associated protein [KO:K08063]
101677618  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101673884  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
101690403  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
101693142  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
mpuf03050  Proteasome
mpuf04650  Natural killer cell mediated cytotoxicity
mpuf04660  T cell receptor signaling pathway
KO pathway
ko04612   
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