KEGG   PATHWAY: msho00230
Entry
msho00230                   Pathway                                
Name
Purine metabolism - Mycobacterium shottsii
Class
Metabolism; Nucleotide metabolism
Pathway map
msho00230  Purine metabolism
msho00230

Module
msho_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:msho00230]
msho_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:msho00230]
msho_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:msho00230]
msho_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:msho00230]
msho_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:msho00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium shottsii [GN:msho]
Gene
MSHO_56270  pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
MSHO_02600  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MSHO_20910  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
MSHO_03740  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MSHO_03470  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MSHO_24110  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
MSHO_20830  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
MSHO_20720  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
MSHO_20730  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
MSHO_20920  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MSHO_60520  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
MSHO_60510  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
MSHO_20560  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MSHO_03650  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MSHO_03460  purH; bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MSHO_50360  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MSHO_61070  punA; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MSHO_45900  laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MSHO_29870  iunH; nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
MSHO_06270  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MSHO_29700  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
MSHO_29710  putative oxidoreductase [KO:K00088] [EC:1.1.1.205]
MSHO_31550  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MSHO_00220  non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
MSHO_25860  oxidoreductase [KO:K11177] [EC:1.17.1.4]
MSHO_25850  hypothetical protein [KO:K11178] [EC:1.17.1.4]
MSHO_29830  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
MSHO_40550  guaB1; putative oxidoreductase [KO:K26110] [EC:1.7.1.7]
MSHO_34420  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
MSHO_56090  nrdE; ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MSHO_56040  nrdF2; ribonucleoside-diphosphate reductase subunit beta nrdF2 [KO:K00526] [EC:1.17.4.1]
MSHO_32980  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
MSHO_50350  relA; putative GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MSHO_02480  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSHO_25710  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSHO_01430  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSHO_02370  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSHO_11230  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MSHO_12300  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MSHO_16160  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSHO_17210  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSHO_23920  cya_1; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSHO_24700  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSHO_27020  guanylate cyclase [KO:K01768] [EC:4.6.1.1]
MSHO_33130  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSHO_36610  cya_2; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSHO_44100  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSHO_24040  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
MSHO_46590  adoK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
MSHO_30600  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
MSHO_28680  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
MSHO_56620  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MSHO_02530  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MSHO_20850  cpdA; 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA [KO:K03651] [EC:3.1.4.53]
MSHO_50710  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
MSHO_16700  cysNC; bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MSHO_16690  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
MSHO_03950  hypothetical protein [KO:K16839] [EC:1.14.13.113]
MSHO_03980  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
MSHO_03990  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
MSHO_02460  Asp/Glu racemase [KO:K16841] [EC:5.1.99.3]
MSHO_61150  alc; putative allantoicase [KO:K01477] [EC:3.5.3.4]
MSHO_40670  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MSHO_40660  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
MSHO_40650  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
msho00030  Pentose phosphate pathway
msho00220  Arginine biosynthesis
msho00250  Alanine, aspartate and glutamate metabolism
msho00260  Glycine, serine and threonine metabolism
msho00340  Histidine metabolism
msho00630  Glyoxylate and dicarboxylate metabolism
msho00730  Thiamine metabolism
msho00740  Riboflavin metabolism
msho00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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