KEGG   PATHWAY: mthn00230
Entry
mthn00230                   Pathway                                
Name
Purine metabolism - Mycolicibacterium thermoresistibile
Class
Metabolism; Nucleotide metabolism
Pathway map
mthn00230  Purine metabolism
mthn00230

Module
mthn_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mthn00230]
mthn_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mthn00230]
mthn_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mthn00230]
mthn_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mthn00230]
mthn_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mthn00230]
Other DBs
GO: 0006163 0042278
Organism
Mycolicibacterium thermoresistibile [GN:mthn]
Gene
4412656_00464  purA; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
4412656_00467  purT; formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [KO:K08289] [EC:6.3.1.21]
4412656_00589  gppA_1; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
4412656_00985  adk; adenylate kinase family protein [KO:K00939] [EC:2.7.4.3]
4412656_01054  guaB_1; inosine-5'-monophosphate (Imp) dehydrogenase, GuaB2 [KO:K00088] [EC:1.1.1.205]
4412656_01055  [KO:K00088] [EC:1.1.1.205]
4412656_01062  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
4412656_01075  rihA; Inosine-uridine nucleoside N-ribohydrolase [KO:K01239] [EC:3.2.2.1]
4412656_01117  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
4412656_01128  punA; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
4412656_01177  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
4412656_01178  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
4412656_01393  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
4412656_01477  nrdE_1; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
4412656_01489  nrdF; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
4412656_01729  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
4412656_01836  adoK; sugar kinase [KO:K00856] [EC:2.7.1.20]
4412656_01888  yfiH; membrane protein YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
4412656_02055  cya_1; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
4412656_02258  guaB_2; inosine-5-monophosphate dehydrogenase guaB1 [KO:K26110]
4412656_02264  ureA; urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
4412656_02265  ureB; urease, beta subunit [KO:K01429] [EC:3.5.1.5]
4412656_02266  ureC; urease alpha subunit UreC [KO:K01428] [EC:3.5.1.5]
4412656_02575  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
4412656_02646  relA_2; (p)ppGpp synthetase, RelA/SpoT family [KO:K01139] [EC:2.7.6.5 3.1.7.2]
4412656_02647  apt; PRPP-binding protein, adenine/guanine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
4412656_02666  [KO:K19710] [EC:2.7.7.53]
4412656_02860  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
4412656_03080  cyaB_1; adenylate cyclase, family protein 3 [KO:K01768] [EC:4.6.1.1]
4412656_03134  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
4412656_03283  cysNC; Adenylylsulfate kinase / sulfate adenylyltransferase subunit 1 [KO:K00955] [EC:2.7.7.4 2.7.1.25]
4412656_03284  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
4412656_03309  [KO:K01768] [EC:4.6.1.1]
4412656_03530  nrdE_2; ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
4412656_03611  [KO:K00526] [EC:1.17.4.1]
4412656_03622  gppA_2; Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
4412656_03629  mazG; MazG nucleotide pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
4412656_03637  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
4412656_03767  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
4412656_03768  purN; phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent [KO:K11175] [EC:2.1.2.2]
4412656_03940  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
4412656_03942  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
4412656_03947  purL; phosphoribosylformylglycinamidine synthase subunit II [KO:K23269]
4412656_03956  purQ; phosphoribosylformylglycinamidine synthase I [KO:K23265]
4412656_03957  yexA; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264]
4412656_03968  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
4412656_03972  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
4412656_03977  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
4412656_04149  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
4412656_04241  cyaB_3; family 3 adenylate cyclase [KO:K01768] [EC:4.6.1.1]
4412656_04559  nrdF1; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
4412656_04663  surE; survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mthn00030  Pentose phosphate pathway
mthn00220  Arginine biosynthesis
mthn00250  Alanine, aspartate and glutamate metabolism
mthn00260  Glycine, serine and threonine metabolism
mthn00340  Histidine metabolism
mthn00630  Glyoxylate and dicarboxylate metabolism
mthn00730  Thiamine metabolism
mthn00740  Riboflavin metabolism
mthn00790  Folate biosynthesis
KO pathway
ko00230   

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