KEGG   PATHWAY: mtv00230
Entry
mtv00230                    Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis H37Rv
Class
Metabolism; Nucleotide metabolism
Pathway map
mtv00230  Purine metabolism
mtv00230

Module
mtv_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtv00230]
mtv_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mtv00230]
mtv_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mtv00230]
mtv_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mtv00230]
mtv_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mtv00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis H37Rv [GN:mtv]
Gene
RVBD_3068c  phosphoglucomutase PgmA [KO:K01835] [EC:5.4.2.2]
RVBD_1017c  ribose-phosphate pyrophosphokinase PrsA [KO:K00948] [EC:2.7.6.1]
RVBD_0808  amidophosphoribosyltransferase PurF [KO:K00764] [EC:2.4.2.14]
RVBD_0772  phosphoribosylamine glycine ligase PurD [KO:K01945] [EC:6.3.4.13]
RVBD_0956  5'-phosphoribosylglycinamide formyltransferase PurN [KO:K11175] [EC:2.1.2.2]
RVBD_0389  phosphoribosylglycinamide formyltransferase 2 PurT [KO:K08289] [EC:6.3.1.21]
RVBD_0803  phosphoribosylformylglycinamidine synthase II PurL [KO:K23269] [EC:6.3.5.3]
RVBD_0787A  phosphoribosylformylglycinamidine synthase [KO:K23264] [EC:6.3.5.3]
RVBD_0788  phosphoribosylformylglycinamidine synthase I PURG [KO:K23265] [EC:6.3.5.3 3.5.1.2]
RVBD_0809  phosphoribosylformylglycinamidine CYCLO-ligase PurM [KO:K01933] [EC:6.3.3.1]
RVBD_3276c  phosphoribosylaminoimidazole carboxylase ATPase subunit PurK [KO:K01589] [EC:6.3.4.18]
RVBD_3275c  phosphoribosylaminoimidazole carboxylase catalytic subunit PurE [KO:K01588] [EC:5.4.99.18]
RVBD_0780  phosphoribosylaminoimidazole-succinocarboxamide synthase PurC [KO:K01923] [EC:6.3.2.6]
RVBD_0777  adenylosuccinate lyase PurB [KO:K01756] [EC:4.3.2.2]
RVBD_0957  bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
RVBD_2584c  adenine phosphoribosyltransferase Apt [KO:K00759] [EC:2.4.2.7]
RVBD_3307  purine nucleoside phosphorylase DeoD [KO:K03783] [EC:2.4.2.1]
RVBD_2149c  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
RVBD_3393  nucleoside hydrolase LunH [KO:K01239] [EC:3.2.2.1]
RVBD_3624c  hypoxanthine-guanine phosphoribosyltransferase Hpt [KO:K00760] [EC:2.4.2.8]
RVBD_3410c  inosine-5'-monophosphate dehydrogenase GuaB3 [KO:K00088] [EC:1.1.1.205]
RVBD_3411c  inosine-5'-monophosphate dehydrogenase GuaB2 [KO:K00088] [EC:1.1.1.205]
RVBD_2445c  nucleoside diphosphate kinase NdkA [KO:K00940] [EC:2.7.4.6]
RVBD_1341  nucleoside-triphosphatase [KO:K01519] [EC:3.6.1.66]
RVBD_3396c  GMP synthase GuaA [KO:K01951] [EC:6.3.5.2]
RVBD_1843c  inosine-5'-monophosphate dehydrogenase GuaB1 [KO:K26110] [EC:1.7.1.7]
RVBD_1389  guanylate kinase Gmk [KO:K00942] [EC:2.7.4.8]
RVBD_3051c  ribonucleoside-diphosphate reductase NrdE [KO:K00525] [EC:1.17.4.1]
RVBD_0570  ribonucleoside-diphosphate reductase NrdZ [KO:K00525] [EC:1.17.4.1]
RVBD_3048c  ribonucleoside-diphosphate reductase NrdF2 [KO:K00526] [EC:1.17.4.1]
RVBD_0233  ribonucleoside-diphosphate reductase NrdB [KO:K00526] [EC:1.17.4.1]
RVBD_1981c  ribonucleoside-diphosphate reductase NrdF1 [KO:K00526] [EC:1.17.4.1]
RVBD_2344c  deoxyguanosine triphosphate triphosphohydrolase Dgt [KO:K01129] [EC:3.1.5.1]
RVBD_2583c  GTP pyrophosphokinase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
RVBD_0496  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
RVBD_1026  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
RVBD_1264  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
RVBD_1625c  adenylyl cyclase Cya [KO:K01768] [EC:4.6.1.1]
RVBD_3645  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
RVBD_0357c  adenylosuccinate synthetase PurA [KO:K01939] [EC:6.3.4.4]
RVBD_2202c  adenosine kinase AdoK [KO:K00856] [EC:2.7.1.20]
RVBD_3313c  adenosine deaminase Add [KO:K01488] [EC:3.5.4.4]
RVBD_0733  adenylate kinase Adk [KO:K00939] [EC:2.7.4.3]
RVBD_1021  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
RVBD_0805  cyclic nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
RVBD_2613c  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
RVBD_1286  bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
RVBD_1285  sulfate adenylyltransferase subunit 2 CysD [KO:K00957] [EC:2.7.7.4]
RVBD_1850  urease alpha subunit UreC [KO:K01428] [EC:3.5.1.5]
RVBD_1849  urease beta subunit UreB [KO:K01429] [EC:3.5.1.5]
RVBD_1848  urease gamma subunit UreA [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mtv00030  Pentose phosphate pathway
mtv00220  Arginine biosynthesis
mtv00250  Alanine, aspartate and glutamate metabolism
mtv00260  Glycine, serine and threonine metabolism
mtv00340  Histidine metabolism
mtv00630  Glyoxylate and dicarboxylate metabolism
mtv00730  Thiamine metabolism
mtv00740  Riboflavin metabolism
mtv00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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