KEGG   PATHWAY: mvm00260
Entry
mvm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Mycolicibacter virginiensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mvm00260  Glycine, serine and threonine metabolism
mvm00260

Module
mvm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mvm00260]
mvm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mvm00260]
mvm_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:mvm00260]
mvm_M00621  Glycine cleavage system [PATH:mvm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycolicibacter virginiensis [GN:mvm]
Gene
MJO54_21785  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MJO54_21780  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MJO54_07175  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MJO54_07185  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
MJO54_07180  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MJO54_05965  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MJO54_09540  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MJO54_02785  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
MJO54_15500  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MJO54_04385  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
MJO54_15875  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MJO54_04785  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
MJO54_11065  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MJO54_09510  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
MJO54_02630  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MJO54_11040  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MJO54_02195  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MJO54_05865  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MJO54_02350  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
MJO54_12165  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
MJO54_11995  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
MJO54_12000  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
MJO54_15390  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
MJO54_15385  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
MJO54_15395  ectoine synthase [KO:K06720] [EC:4.2.1.108]
MJO54_15400  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mvm00010  Glycolysis / Gluconeogenesis
mvm00020  Citrate cycle (TCA cycle)
mvm00230  Purine metabolism
mvm00250  Alanine, aspartate and glutamate metabolism
mvm00270  Cysteine and methionine metabolism
mvm00290  Valine, leucine and isoleucine biosynthesis
mvm00300  Lysine biosynthesis
mvm00330  Arginine and proline metabolism
mvm00460  Cyanoamino acid metabolism
mvm00470  D-Amino acid metabolism
mvm00564  Glycerophospholipid metabolism
mvm00600  Sphingolipid metabolism
mvm00620  Pyruvate metabolism
mvm00630  Glyoxylate and dicarboxylate metabolism
mvm00640  Propanoate metabolism
mvm00680  Methane metabolism
mvm00860  Porphyrin metabolism
mvm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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