KEGG   PATHWAY: nnt03013
Entry
nnt03013                    Pathway                                
Name
Nucleocytoplasmic transport - Nestor notabilis (Kea)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
nnt03013  Nucleocytoplasmic transport
nnt03013

Other DBs
GO: 0050658
Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104398992  [KO:K14285]
104399140  NUPL2; nucleoporin-like protein 2 [KO:K14321]
104399230  RAE1; mRNA export factor [KO:K14298]
104399291  [KO:K14293]
104399321  XPO4; exportin-4 [KO:K25203]
104399338  [KO:K12877]
104399360  NUP188; nucleoporin NUP188 homolog [KO:K14311]
104399390  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
104399509  [KO:K25201]
104399545  CSE1L; exportin-2 isoform X1 [KO:K18423]
104399572  XPO1; exportin-1 [KO:K14290]
104399841  [KO:K12160]
104399972  NUPL1; LOW QUALITY PROTEIN: nucleoporin p58/p45 [KO:K14307]
104399986  NUP43; nucleoporin Nup43 [KO:K14305]
104400007  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
104400021  TMEM33; transmembrane protein 33 [KO:K20724]
104400066  THOC7; THO complex subunit 7 homolog [KO:K13176]
104400366  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104400561  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
104400719  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
104400724  [KO:K12883]
104401164  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104401249  [KO:K12160]
104401302  TNPO3; transportin-3 [KO:K15436]
104401661  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
104401754  KPNA6; importin subunit alpha-7 [KO:K15042]
104402053  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
104402101  IPO8; importin-8 [KO:K18755]
104402802  XPOT; exportin-T [KO:K14288]
104402872  THOC5; THO complex subunit 5 homolog [KO:K13174]
104402934  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
104402955  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
104402982  NUP214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
104403119  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
104403283  XPO5; LOW QUALITY PROTEIN: exportin-5 [KO:K14289]
104403425  NDC1; nucleoporin NDC1 [KO:K14315]
104403561  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
104403593  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
104403972  [KO:K18655] [EC:5.6.2.7]
104404291  [KO:K14314]
104404800  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
104404871  THOC2; THO complex subunit 2 [KO:K12879]
104404976  GLE1; nucleoporin GLE1 [KO:K18723]
104404994  NUP54; LOW QUALITY PROTEIN: nucleoporin p54 [KO:K14308]
104405187  IPO13; importin-13 [KO:K25202]
104405394  RANBP2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
104405458  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
104405592  TNPO1; transportin-1 [KO:K18752]
104405719  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
104405869  KPNA4; importin subunit alpha-3 [KO:K23583]
104406061  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104406219  THOC1; THO complex subunit 1 [KO:K12878]
104406353  KPNA2; importin subunit alpha-1 [KO:K15043]
104406460  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
104406545  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
104406719  [KO:K15043]
104407253  SNUPN; snurportin-1 [KO:K13151]
104407311  SEH1L; nucleoporin SEH1 [KO:K14299]
104407693  IPO5; importin-5 [KO:K20222]
104407707  TPR; nucleoprotein TPR [KO:K09291]
104407784  NUP37; nucleoporin Nup37 [KO:K14302]
104407937  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104408001  KPNA3; importin subunit alpha-4 [KO:K23583]
104408116  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
104408258  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
104408268  IPO9; importin-9 [KO:K20224]
104408464  [KO:K14296]
104409058  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104409097  PNN; pinin [KO:K13114]
104409366  THOC3; THO complex subunit 3 [KO:K12880]
104410095  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
104410374  CASC3; LOW QUALITY PROTEIN: protein CASC3 [KO:K14323]
104410807  KPNA1; importin subunit alpha-5 [KO:K23940]
104411249  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
104411801  NUP35; nucleoporin NUP53 isoform X1 [KO:K14313]
104411962  NUP160; LOW QUALITY PROTEIN: nuclear pore complex protein Nup160 [KO:K14303]
104412597  XPO6; exportin-6 [KO:K25204]
104412627  [KO:K13171]
104412684  RAN; GTP-binding nuclear protein Ran [KO:K07936]
104412880  [KO:K14297]
104413203  XPO7; exportin-7 [KO:K18460]
104413211  SEC13; protein SEC13 homolog [KO:K14004]
104413400  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
104413416  IPO7; LOW QUALITY PROTEIN: importin-7 [KO:K20223]
104413699  [KO:K12883]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
nnt03015  mRNA surveillance pathway
KO pathway
ko03013   

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