KEGG   PATHWAY: oah00260
Entry
oah00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Brucella anthropi OAB
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
oah00260  Glycine, serine and threonine metabolism
oah00260

Module
oah_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:oah00260]
oah_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:oah00260]
oah_M00555  Betaine biosynthesis, choline => betaine [PATH:oah00260]
oah_M00621  Glycine cleavage system [PATH:oah00260]
oah_M00919  Ectoine degradation, ectoine => aspartate [PATH:oah00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Brucella anthropi OAB [GN:oah]
Gene
DR92_577  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
DR92_3198  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DR92_1407  ACT domain protein [KO:K00003] [EC:1.1.1.3]
DR92_2350  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
DR92_2275  pyridoxal-phosphate dependent enzyme family protein [KO:K01733] [EC:4.2.3.1]
DR92_2342  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
DR92_3971  psald; phenylserine aldolase [KO:K01620] [EC:4.1.2.48]
DR92_1985  aminotransferase class I and II family protein [KO:K00600] [EC:2.1.2.1]
DR92_3717  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR92_241  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DR92_2477  hypothetical protein [KO:K11529] [EC:2.7.1.165]
DR92_893  gpm1; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DR92_782  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DR92_3399  ACT domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DR92_781  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DR92_1286  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DR92_2529  hemA; 5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
DR92_4399  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
DR92_4397  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
DR92_1555  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR92_479  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR92_2932  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DR92_4398  gcvH; glycine cleavage system H protein [KO:K02437]
DR92_4431  creatinase [KO:K08688] [EC:3.5.3.3]
DR92_2383  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DR92_2191  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DR92_2192  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DR92_1194  putative Ring hydroxylating alpha subunit [KO:K00479] [EC:1.14.13.251]
DR92_1193  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
DR92_4  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DR92_6  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DR92_3  aminomethyltransferase folate-binding domain protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DR92_5  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DR92_3870  metC; cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
DR92_1508  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DR92_1633  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
DR92_3017  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
DR92_2391  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
DR92_350  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
DR92_348  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
DR92_3750  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
DR92_3019  eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
DR92_3020  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
DR92_3014  aminotransferase [KO:K15785] [EC:2.6.1.76]
DR92_3015  gabD; succinate-semialdehyde dehydrogenase [NADP+] [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
oah00010  Glycolysis / Gluconeogenesis
oah00020  Citrate cycle (TCA cycle)
oah00230  Purine metabolism
oah00250  Alanine, aspartate and glutamate metabolism
oah00270  Cysteine and methionine metabolism
oah00290  Valine, leucine and isoleucine biosynthesis
oah00300  Lysine biosynthesis
oah00330  Arginine and proline metabolism
oah00460  Cyanoamino acid metabolism
oah00470  D-Amino acid metabolism
oah00564  Glycerophospholipid metabolism
oah00620  Pyruvate metabolism
oah00630  Glyoxylate and dicarboxylate metabolism
oah00640  Propanoate metabolism
oah00680  Methane metabolism
oah00860  Porphyrin metabolism
oah00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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