KEGG   PATHWAY: omc00983
Entry
omc00983                    Pathway                                
Name
Drug metabolism - other enzymes - Onychostoma macrolepis
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
omc00983  Drug metabolism - other enzymes
omc00983

Organism
Onychostoma macrolepis [GN:omc]
Gene
131534861  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
131553833  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
131524784  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
131545398  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
131538654  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
131524610  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
131525466  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
131523324  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131527245  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
131534961  uncharacterized protein LOC131534961 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
131534960  uncharacterized protein LOC131534960 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
131540589  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131540591  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131541076  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
131541436  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
131548408  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 isoform X1 [KO:K00699] [EC:2.4.1.17]
131524118  ugt5f1; UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
131548805  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 isoform X1 [KO:K00699] [EC:2.4.1.17]
131548924  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131548927  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
131548929  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
131532995  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
131534667  ugt5a2; UDP glucuronosyltransferase 5 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
131534668  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
131534669  ugt5a5; UDP glucuronosyltransferase 5 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
131535841  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131535864  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
131535873  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131544101  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
131545221  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
131546878  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131546880  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131546904  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131546905  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131540390  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131541325  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
131531736  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
131531737  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
131549502  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
131544782  zgc:103586 isoform X1 [KO:K01489] [EC:3.5.4.5]
131539277  tymp; thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
131532634  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
131533613  dpyda.1; dihydropyrimidine dehydrogenase a, tandem duplicate 1 isoform X1 [KO:K00207] [EC:1.3.1.2]
131522188  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
131545580  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
131521473  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
131547311  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
131531905  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
131526295  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
131526699  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
131528783  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
131545707  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
131545763  uckl1a; uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
131549162  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
131544415  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
131546706  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
131532865  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
131528694  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
131525744  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
131527633  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
131542375  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
131550951  nme2a; NME/NM23 nucleoside diphosphate kinase 2a isoform X1 [KO:K00940] [EC:2.7.4.6]
131526354  nucleoside diphosphate kinase B isoform X1 [KO:K00940] [EC:2.7.4.6]
131536882  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
131527700  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
131537494  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
131524322  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
131524455  zgc:101040; arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
131543707  arylamine N-acetyltransferase, pineal gland isozyme NAT-3-like [KO:K00622] [EC:2.3.1.5]
131544392  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
131540808  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
131541018  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
131541167  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
131526154  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
131526298  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
131526578  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
131551701  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
131552225  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
131545469  glutathione S-transferase Mu 4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
131545470  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
131552634  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
131552776  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
131528784  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
131545801  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
131552947  mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
131539481  mgst1.1; microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
131539482  mgst1.2; microsomal glutathione S-transferase 1.2 [KO:K00799] [EC:2.5.1.18]
131553102  gstp1.2; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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