KEGG   PATHWAY: palv00260
Entry
palv00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas alvandae SWRI17
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
palv00260  Glycine, serine and threonine metabolism
palv00260

Module
palv_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:palv00260]
palv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:palv00260]
palv_M00555  Betaine biosynthesis, choline => betaine [PATH:palv00260]
palv_M00621  Glycine cleavage system [PATH:palv00260]
palv_M00919  Ectoine degradation, ectoine => aspartate [PATH:palv00260]
palv_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:palv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas alvandae SWRI17 [GN:palv]
Gene
KSS97_00745  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS97_00775  [KO:K00133] [EC:1.2.1.11]
KSS97_01130  [KO:K02204] [EC:2.7.1.39]
KSS97_01625  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KSS97_01630  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KSS97_02200  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS97_02230  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS97_02790  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KSS97_03740  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
KSS97_04015  [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KSS97_05795  [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KSS97_05920  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
KSS97_05930  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
KSS97_05935  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
KSS97_05945  [KO:K15786] [EC:1.2.1.-]
KSS97_05950  [KO:K15785] [EC:2.6.1.76]
KSS97_06750  [KO:K00130] [EC:1.2.1.8]
KSS97_07155  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KSS97_07160  [KO:K01752] [EC:4.3.1.17]
KSS97_07165  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KSS97_07170  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS97_07735  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KSS97_07745  [KO:K00928] [EC:2.7.2.4]
KSS97_08520  [KO:K11529] [EC:2.7.1.165]
KSS97_08625  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS97_09460  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
KSS97_11405  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS97_11875  [KO:K00865] [EC:2.7.1.165]
KSS97_13535  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS97_14785  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
KSS97_15170  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KSS97_16245  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KSS97_16505  [KO:K00836] [EC:2.6.1.76]
KSS97_16605  [KO:K01754] [EC:4.3.1.19]
KSS97_16950  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS97_18010  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS97_18250  [KO:K11529] [EC:2.7.1.165]
KSS97_19175  [KO:K00479] [EC:1.14.13.251]
KSS97_19180  [KO:K21832] [EC:1.14.13.251]
KSS97_19825  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KSS97_20140  [KO:K00836] [EC:2.6.1.76]
KSS97_20755  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KSS97_23630  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KSS97_23635  [KO:K00003] [EC:1.1.1.3]
KSS97_24135  [KO:K00018] [EC:1.1.1.29]
KSS97_24550  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KSS97_25015  [KO:K00600] [EC:2.1.2.1]
KSS97_25575  [KO:K00003] [EC:1.1.1.3]
KSS97_25585  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KSS97_26775  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
KSS97_26780  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
KSS97_26785  [KO:K00304] [EC:1.5.3.24 1.5.3.1]
KSS97_26790  [KO:K00303] [EC:1.5.3.24 1.5.3.1]
KSS97_26795  [KO:K00600] [EC:2.1.2.1]
KSS97_26805  [KO:K01620] [EC:4.1.2.48]
KSS97_26810  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
KSS97_26815  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
KSS97_26835  [KO:K25961]
KSS97_26840  [KO:K25960]
KSS97_26845  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
KSS97_26850  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
KSS97_26925  [KO:K01752] [EC:4.3.1.17]
KSS97_26955  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KSS97_26960  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KSS97_27155  [KO:K00274] [EC:1.4.3.4]
KSS97_27895  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS97_27900  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
palv00010  Glycolysis / Gluconeogenesis
palv00020  Citrate cycle (TCA cycle)
palv00230  Purine metabolism
palv00250  Alanine, aspartate and glutamate metabolism
palv00270  Cysteine and methionine metabolism
palv00290  Valine, leucine and isoleucine biosynthesis
palv00300  Lysine biosynthesis
palv00330  Arginine and proline metabolism
palv00460  Cyanoamino acid metabolism
palv00470  D-Amino acid metabolism
palv00564  Glycerophospholipid metabolism
palv00620  Pyruvate metabolism
palv00630  Glyoxylate and dicarboxylate metabolism
palv00640  Propanoate metabolism
palv00680  Methane metabolism
palv00860  Porphyrin metabolism
palv00920  Sulfur metabolism
KO pathway
ko00260   

DBGET integrated database retrieval system