KEGG   PATHWAY: aang00983
Entry
aang00983                   Pathway                                
Name
Drug metabolism - other enzymes - Anguilla anguilla (European eel)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
aang00983  Drug metabolism - other enzymes
aang00983

Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118235635  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
118224136  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
118214866  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
118219276  inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
118208687  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
118209534  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
118229665  GMP synthase [glutamine-hydrolyzing]-like isoform X1 [KO:K01951] [EC:6.3.5.2]
118234581  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
118223068  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
118225916  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
118215312  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118215445  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
118223643  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
118213040  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118219474  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
118207666  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
118214724  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118214725  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118227637  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118227638  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
118227639  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118235632  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
118211348  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
118207501  cdaa; cytidine deaminase a [KO:K01489] [EC:3.5.4.5]
118231032  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
118225829  dpyda.1; dihydropyrimidine dehydrogenase a, tandem duplicate 1 [KO:K00207] [EC:1.3.1.2]
118235471  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
118206985  upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
118230302  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
118213764  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
118229227  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
118210686  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
118212084  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
118225904  uck2a; uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
118207688  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
118215812  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
118216842  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
118220961  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
118222428  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
118229794  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
118224498  UMP-CMP kinase-like isoform X1 [KO:K13800] [EC:2.7.4.14]
118236069  rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
118230138  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
118234113  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
118221731  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
118229139  nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
118217190  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
118217322  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
118217333  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
118220294  nucleoside diphosphate kinase, mitochondrial-like isoform X1 [KO:K00940] [EC:2.7.4.6]
118214170  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
118220807  nme2a; NME/NM23 nucleoside diphosphate kinase 2a [KO:K00940] [EC:2.7.4.6]
118215765  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
118227284  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
118214903  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
118214904  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
118214905  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
118214923  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
118217612  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118218686  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118231768  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118206843  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
118212792  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
118207796  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
118207797  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118233362  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118233364  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118213628  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
118237188  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
118228221  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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