KEGG   PATHWAY: acep04150
Entry
acep04150                   Pathway                                
Name
mTOR signaling pathway - Atta cephalotes (leaf cutting ant)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
acep04150  mTOR signaling pathway
acep04150

Organism
Atta cephalotes (leaf cutting ant) [GN:acep]
Gene
105620984  Y+L amino acid transporter 2 [KO:K13780]
105625633  Y+L amino acid transporter 2 [KO:K13780]
105621404  maltase 1 [KO:K06519]
105626241  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
105620523  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105624815  V-type proton ATPase subunit B [KO:K02147]
105624411  LOW QUALITY PROTEIN: V-type proton ATPase subunit C [KO:K02148]
105626388  V-type proton ATPase subunit D [KO:K02149]
105626877  V-type proton ATPase subunit E [KO:K02150]
105625634  V-type proton ATPase subunit F 1 [KO:K02151]
105625890  V-type proton ATPase subunit G [KO:K02152]
105627677  V-type proton ATPase subunit H [KO:K02144]
105625506  ragulator complex protein LAMTOR1 [KO:K20397]
105624264  ragulator complex protein LAMTOR2 [KO:K20398]
105627402  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-A [KO:K04370]
105623863  ragulator complex protein LAMTOR4 homolog [KO:K20399]
105624791  uncharacterized protein LOC105624791 [KO:K16344]
105625526  folliculin [KO:K09594]
105619412  folliculin-interacting protein 1 [KO:K20401]
105624843  ras-related GTP-binding protein A [KO:K16185]
105624036  ras-related GTP-binding protein C [KO:K16186]
105618820  WD repeat-containing protein mio-B [KO:K20407]
105618098  nucleoporin SEH1 [KO:K14299]
105626255  WD repeat-containing protein 24 [KO:K20408]
105621098  WD repeat-containing protein 59 [KO:K20409]
105621977  protein SEC13 homolog [KO:K14004]
105626681  DEP domain-containing protein 5 [KO:K20404]
105619812  nitrogen permease regulator 2-like protein [KO:K20405]
105618175  nitrogen permease regulator 3-like protein [KO:K20406]
105620077  S-phase kinase-associated protein 2 [KO:K03875]
105622426  regulatory-associated protein of mTOR [KO:K07204]
105618850  uncharacterized protein LOC105618850 [KO:K16184]
105624966  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105627419  target of rapamycin complex subunit lst8 [KO:K08266]
105627813  TELO2-interacting protein 1 homolog [KO:K20403]
105619124  LOW QUALITY PROTEIN: restin homolog [KO:K10421]
105622436  phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
105619240  serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105623699  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
105620482  eukaryotic translation initiation factor 4E-like [KO:K03259]
105622978  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105623070  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
105623758  eukaryotic translation initiation factor 4B-like [KO:K03258]
105619035  40S ribosomal protein S6 [KO:K02991]
105627507  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105622989  protein Mo25 [KO:K08272]
105627819  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105626702  hamartin [KO:K07206]
105624503  tuberin [KO:K07207]
105624341  TBC1 domain family member 7 [KO:K20396]
105621587  GTP-binding protein Rheb homolog [KO:K07208]
105618733  protein Wnt-1 [KO:K03209]
105619381  protein Wnt-1-like [KO:K00408]
105618833  protein Wnt-5b-like [KO:K00444]
105618731  protein Wnt-6-like [KO:K00445]
105618028  protein Wnt-7b [KO:K00572]
105618732  protein Wnt-10a [KO:K01357]
105618227  protein Wnt-11b-1-like [KO:K01384]
105618993  frizzled-7-B [KO:K02432]
105625235  uncharacterized protein LOC105625235 [KO:K02354]
105624586  frizzled-4 [KO:K02354]
105619144  frizzled-2 [KO:K02375]
105625668  frizzled-9-like [KO:K02842]
105621886  low-density lipoprotein receptor-related protein 6 [KO:K03068]
105624974  segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
105620830  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
105623150  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105625577  LIRP [KO:K04526]
105617935  insulin-like growth factor II [KO:K05459]
105619053  protein enhancer of sevenless 2B [KO:K04364]
105618963  protein son of sevenless [KO:K03099]
105617956  GTPase HRas [KO:K07827]
105623044  serine/threonine-protein kinase A-Raf [KO:K04365] [EC:2.7.11.1]
105625005  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
105627106  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105624525  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
105627057  chitinase-like protein PB1E7.04c [KO:K16172]
105620878  uncharacterized protein LOC105620878 [KO:K02649]
105620083  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105619919  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105620300  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105623661  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105619943  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
105621095  rapamycin-insensitive companion of mTOR [KO:K08267]
105623459  ras-like GTP-binding protein Rho1 [KO:K04513]
105627224  protein kinase C, brain isozyme [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
acep00561  Glycerolipid metabolism
acep04140  Autophagy - animal
KO pathway
ko04150   
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