KEGG   PATHWAY: ache00260
Entry
ache00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus chevalieri
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ache00260  Glycine, serine and threonine metabolism
ache00260

Module
ache_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ache00260]
ache_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ache00260]
ache_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ache00260]
ache_M00621  Glycine cleavage system [PATH:ache00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus chevalieri [GN:ache]
Gene
ACHE_11224A  HOM3; aspartokinase [KO:K00928] [EC:2.7.2.4]
ACHE_70396A  uncharacterized protein [KO:K00133] [EC:1.2.1.11]
ACHE_21151S  uncharacterized protein [KO:K00003] [EC:1.1.1.3]
ACHE_11204S  THR1; trihydroxynaphthalene reductase [KO:K00872] [EC:2.7.1.39]
ACHE_40412S  THR4_1; threonine synthase [KO:K01733] [EC:4.2.3.1]
ACHE_10448S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
ACHE_20724A  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
ACHE_31341A  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
ACHE_41187A  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
ACHE_20882A  SHM2; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
ACHE_50324S  SHM1; glycine hydroxymethyltransferase shm1 [KO:K00600] [EC:2.1.2.1]
ACHE_30936S  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
ACHE_20884S  uncharacterized protein [KO:K15633] [EC:5.4.2.12]
ACHE_31142S  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
ACHE_11232A  SER3; phosphoglycerate dehydrogenase Ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ACHE_50240S  SER1; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
ACHE_70425S  uncharacterized protein [KO:K01079] [EC:3.1.3.3]
ACHE_41112A  putative secondary metabolism biosynthetic enzyme [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ACHE_20491S  HEM1; mitochondrial 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
ACHE_80191S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
ACHE_51294A  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
ACHE_20029A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
ACHE_40206A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
ACHE_40359A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
ACHE_50629A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
ACHE_31202A  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
ACHE_30123A  GCV1; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
ACHE_40445S  LPD1; dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
ACHE_30312S  GCV3; glycine cleavage system H-protein subunit [KO:K02437]
ACHE_60836A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
ACHE_41126A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
ACHE_51214A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
ACHE_30467A  uncharacterized protein [KO:K00613] [EC:2.1.4.1]
ACHE_10413S  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
ACHE_60711S  uncharacterized protein [KO:K00130] [EC:1.2.1.8]
ACHE_20201S  uncharacterized protein [KO:K00309] [EC:1.5.3.10]
ACHE_60237S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_60422S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_20198A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_20972A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_40470S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_51104A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ACHE_50303A  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
ACHE_60684S  CYS3; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]
ACHE_70808S  ILV1; threonine deaminase [KO:K01754] [EC:4.3.1.19]
ACHE_20045S  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
ACHE_70800S  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
ACHE_31210A  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
ACHE_40770S  TRP5; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ache00010  Glycolysis / Gluconeogenesis
ache00020  Citrate cycle (TCA cycle)
ache00230  Purine metabolism
ache00250  Alanine, aspartate and glutamate metabolism
ache00270  Cysteine and methionine metabolism
ache00290  Valine, leucine and isoleucine biosynthesis
ache00300  Lysine biosynthesis
ache00330  Arginine and proline metabolism
ache00460  Cyanoamino acid metabolism
ache00470  D-Amino acid metabolism
ache00564  Glycerophospholipid metabolism
ache00600  Sphingolipid metabolism
ache00620  Pyruvate metabolism
ache00630  Glyoxylate and dicarboxylate metabolism
ache00640  Propanoate metabolism
ache00680  Methane metabolism
ache00860  Porphyrin metabolism
ache00920  Sulfur metabolism
KO pathway
ko00260   
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