KEGG   PATHWAY: aew00053
Entry
aew00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Actinidia eriantha (wild kiwifruit)
Class
Metabolism; Carbohydrate metabolism
Pathway map
aew00053  Ascorbate and aldarate metabolism
aew00053

Module
aew_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:aew00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Actinidia eriantha (wild kiwifruit) [GN:aew]
Gene
130773997  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
130777019  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
130768212  LOW QUALITY PROTEIN: UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
130769348  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
130796045  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
130776324  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
130758359  UDP-sugar pyrophosphorylase-like isoform X1 [KO:K12447] [EC:2.7.7.64]
130776914  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
130769342  LOW QUALITY PROTEIN: glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
130761803  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
130788525  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
130750521  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
130757755  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
130784369  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
130751075  LOW QUALITY PROTEIN: NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
130766028  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
130781477  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
130781576  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
130794213  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
130782846  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
130780420  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
130780539  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
130756181  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
130775020  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
130763643  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
130751975  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
130769194  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
130772389  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
130752343  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
130759734  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
130779094  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
130755705  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
130757673  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
130752534  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
130792587  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
130780813  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
130768866  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
130781995  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
130796270  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
130784857  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
130766070  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
130781069  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
130781622  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
130756771  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
130795620  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
130788907  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
130776944  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
130765878  LOW QUALITY PROTEIN: monodehydroascorbate reductase, chloroplastic/mitochondrial-like [KO:K08232] [EC:1.6.5.4]
130768323  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
130795300  monodehydroascorbate reductase, chloroplastic/mitochondrial-like [KO:K08232] [EC:1.6.5.4]
130757496  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
130761389  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
130774563  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
130776361  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
130765063  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
130790637  LOW QUALITY PROTEIN: L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
130781750  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
130794021  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
130755544  L-ascorbate peroxidase, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
130769979  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
130759158  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
130763539  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
130777636  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
130781758  probable glutathione S-transferase DHAR2, chloroplastic isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
130758469  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
130761307  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
130791547  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
130794981  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
130769663  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
130772844  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
130786550  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
130788545  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
130750447  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
130780243  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
130767257  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
130767358  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
130770329  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
130783741  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
130772465  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
130762503  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
aew00020  Citrate cycle (TCA cycle)
aew00040  Pentose and glucuronate interconversions
aew00051  Fructose and mannose metabolism
aew00520  Amino sugar and nucleotide sugar metabolism
aew00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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