KEGG   PATHWAY: afun03040
Entry
afun03040                   Pathway                                
Name
Spliceosome - Anopheles funestus (African malaria mosquito)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
afun03040  Spliceosome
afun03040

Other DBs
GO: 0005681
Organism
Anopheles funestus (African malaria mosquito) [GN:afun]
Gene
125766686  U1 spliceosomal RNA [KO:K14276]
125772495  U1 spliceosomal RNA [KO:K14276]
125772501  U2 spliceosomal RNA [KO:K14277]
125766676  U2 spliceosomal RNA [KO:K14277]
125772505  U4 spliceosomal RNA [KO:K14278]
125766680  U5 spliceosomal RNA [KO:K14279]
125766679  U5 spliceosomal RNA [KO:K14279]
125766683  U6 spliceosomal RNA [KO:K14280]
125770884  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
125762669  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
125763945  ATP-dependent RNA helicase WM6-like [KO:K12812] [EC:5.6.2.7]
125761927  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
125764114  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
125764487  pre-mRNA-processing factor 17 [KO:K12816]
125765813  pre-mRNA-splicing factor 18 [KO:K12817]
125770634  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
125770445  pre-mRNA-splicing factor Slu7 [KO:K12819]
125768500  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
125772294  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
125768629  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
125775230  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
125771840  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
125769923  probable small nuclear ribonucleoprotein E [KO:K11097]
125765270  small nuclear ribonucleoprotein F [KO:K11098]
125760533  probable small nuclear ribonucleoprotein G [KO:K11099]
125771167  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
125774888  U1 small nuclear ribonucleoprotein C [KO:K11095]
125766021  pre-mRNA-processing factor 40 homolog A [KO:K12821]
125764780  RNA-binding protein 25 [KO:K12822]
125762053  uncharacterized protein LOC125762053 isoform X1 [KO:K12823] [EC:5.6.2.7]
125770946  uncharacterized protein LOC125770946 [KO:K12823] [EC:5.6.2.7]
125772126  uncharacterized protein LOC125772126 isoform X1 [KO:K12823] [EC:5.6.2.7]
125768355  uncharacterized protein LOC125768355 [KO:K12823] [EC:5.6.2.7]
125769183  uncharacterized protein LOC125769183 [KO:K12823] [EC:5.6.2.7]
125769585  transcription elongation regulator 1 [KO:K12824]
125774863  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
125768255  probable U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
125767416  U1 small nuclear ribonucleoprotein A [KO:K11094]
125771647  splicing factor 3A subunit 1 [KO:K12825]
125771824  uncharacterized protein LOC125771824 isoform X1 [KO:K12826]
125771829  uncharacterized protein LOC125771829 isoform X1 [KO:K12826]
125767361  splicing factor 3A subunit 2 [KO:K12826]
125767364  uncharacterized protein LOC125767364 isoform X1 [KO:K12826]
125764407  splicing factor 3A subunit 3 [KO:K12827]
125767796  splicing factor 3B subunit 1-like [KO:K12828]
125767798  splicing factor 3B subunit 1-like [KO:K12828]
125767873  splicing factor 3B subunit 2 [KO:K12829]
125770846  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
125765081  splicing factor 3B subunit 4 [KO:K12831]
125770294  splicing factor 3B subunit 5 [KO:K12832]
125764375  splicing factor 3B subunit 6 [KO:K12833]
125764836  PHD finger-like domain-containing protein 5A [KO:K12834]
125768103  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
125764751  splicing factor U2af 38 kDa subunit [KO:K12836]
125766292  splicing factor U2AF 50 kDa subunit [KO:K12837]
125767211  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
125770401  survival of motor neuron-related-splicing factor 30 [KO:K12839]
125763485  splicing factor 45 [KO:K12840]
125769270  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
125769992  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
125768955  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
125765194  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
125762547  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
125767709  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
125768958  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
125762117  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
125770289  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
125767764  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
125764718  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
125768143  peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
125767030  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
125762204  NHP2-like protein 1 homolog [KO:K12845]
125761390  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
125763792  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
125765549  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
125770403  zinc finger matrin-type protein 2 [KO:K12848]
125765967  pre-mRNA-splicing factor 38 [KO:K12849]
125770086  pre-mRNA-splicing factor 38B [KO:K12850]
125770780  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
125765221  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
125772419  pre-mRNA-processing factor 6 [KO:K12855]
125768807  pre-mRNA-processing-splicing factor 8 [KO:K12856]
125763511  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
125762783  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
125775195  thioredoxin-like protein 4A [KO:K12859]
125771857  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
125764680  cell division cycle 5-like protein [KO:K12860]
125765827  pre-mRNA-splicing factor SPF27 [KO:K12861]
125770579  pleiotropic regulator 1 [KO:K12862]
125767085  protein CWC15 homolog [KO:K12863]
125763072  beta-catenin-like protein 1 [KO:K12864]
125770950  heat shock 70 kDa protein cognate 4-like [KO:K03283]
125764994  heat shock 70 kDa protein cognate 4 [KO:K03283]
125760672  heat shock protein 70 A1-like [KO:K03283]
125760673  heat shock protein 70 A1-like [KO:K03283]
125760674  heat shock protein 70 A1 [KO:K03283]
125760675  heat shock protein 70 A1-like [KO:K03283]
125760676  heat shock protein 70 A1-like [KO:K03283]
125760677  heat shock protein 70 A1-like [KO:K03283]
125760683  heat shock protein 70 A1 [KO:K03283]
125760684  heat shock protein 70 A1-like [KO:K03283]
125765696  WW domain-binding protein 11 [KO:K12866]
125764422  puff-specific protein Bx42 [KO:K06063]
125771778  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
125769677  pre-mRNA-splicing factor Syf2 [KO:K12868]
125774755  protein crooked neck [KO:K12869]
125765343  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
125771835  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
125764845  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
125760980  coiled-coil domain-containing protein 12 [KO:K12871]
125761096  pre-mRNA-splicing factor RBM22 [KO:K12872]
125765838  protein BUD31 homolog [KO:K12873]
125764909  RNA helicase aquarius [KO:K12874]
125763910  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
125764856  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
125772073  RNA-binding protein 8A [KO:K12876]
125772409  protein mago nashi [KO:K12877]
125764982  THO complex subunit 1 [KO:K12878]
125762875  THO complex subunit 2 isoform X1 [KO:K12879]
125760952  THO complex subunit 3 [KO:K12880]
125771573  THO complex subunit 4 [KO:K12881]
125760706  nuclear cap-binding protein subunit 1 [KO:K12882]
125765171  nuclear cap-binding protein subunit 2 [KO:K12883]
125762992  heterogeneous nuclear ribonucleoprotein 87F-like [KO:K12741]
125767850  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
125769675  serine/arginine-rich splicing factor 1A [KO:K12890]
125762850  serine/arginine-rich splicing factor 2 [KO:K12891]
125764139  serine-arginine protein 55 isoform X1 [KO:K12893]
125775185  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
125761626  transformer-2 protein homolog beta-like [KO:K12897]
125771185  transformer-2 protein homolog alpha-like [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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