KEGG   PATHWAY: alat00983
Entry
alat00983                   Pathway                                
Name
Drug metabolism - other enzymes - Acanthopagrus latus (yellowfin seabream)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
alat00983  Drug metabolism - other enzymes
alat00983

Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119007125  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
119023695  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
119023252  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
119024761  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
119032842  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
119007328  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
119017229  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
119015110  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119028279  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119024860  ces2b; uncharacterized protein ces2b [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119030572  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119030661  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119030705  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119010305  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
119017620  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119017624  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119018062  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119018063  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
119018064  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
119018065  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119018071  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
119024971  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119025547  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
119011643  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
119019180  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119020093  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119020094  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119027777  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
119031813  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
119009007  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
119027298  zgc:103586 [KO:K01489] [EC:3.5.4.5]
119021204  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
119032513  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
119010710  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
119006542  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
119019081  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
119006159  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
119006699  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
119025504  upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
119028527  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
119022302  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119022717  uckl1a; uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
119029771  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
119011616  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
119012551  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119016894  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
119034124  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
119026340  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
119011495  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
119030806  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
119033355  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119017446  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
119012785  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119012786  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119028247  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
119014727  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
119010132  nucleoside diphosphate kinase A1-like [KO:K00940] [EC:2.7.4.6]
119012958  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
119013327  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
119013710  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
119017537  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
119018174  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
119007304  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
119005119  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
119022685  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119022745  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
119017088  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119017089  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119017090  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119017091  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119017093  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119017176  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119010758  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
119019032  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
119033454  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
119020300  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
119033790  glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119033791  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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