KEGG   PATHWAY: alim00983
Entry
alim00983                   Pathway                                
Name
Drug metabolism - other enzymes - Austrofundulus limnaeus (annual killifish)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
alim00983  Drug metabolism - other enzymes
alim00983

Organism
Austrofundulus limnaeus (annual killifish) [GN:alim]
Gene
106528855  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
106520303  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
106513095  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
106520329  inosine-5'-monophosphate dehydrogenase 1a-like isoform X1 [KO:K00088] [EC:1.1.1.205]
106514771  impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
106520616  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
106536398  tpmt; thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
106531265  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106533577  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106515621  uncharacterized protein LOC106515621 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
106521877  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106521878  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106517931  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
106523143  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106514153  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
106514154  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106528914  uncharacterized protein LOC106528914 [KO:K00699] [EC:2.4.1.17]
106528915  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106525415  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
106513338  cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
106511203  tymp; thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
106524919  dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
106523615  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
106527484  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
106523309  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
106529475  upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
106527179  uridine-cytidine kinase 2-B isoform X1 [KO:K00876] [EC:2.7.1.48]
106523550  uckl1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106531224  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106529302  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
106536074  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106516286  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
106534980  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106521439  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
106514890  tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
106523164  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106530400  cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106527842  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106516384  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
106511294  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:1.17.4.1]
106530776  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106515853  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
106516475  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
106524395  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106525289  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106527999  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
106528082  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106528168  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
106521628  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
106530373  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
106536371  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
106536289  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106532066  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106532067  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106535069  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106535070  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106536548  LOW QUALITY PROTEIN: microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106521873  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106528813  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
106530569  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106525860  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
106519973  mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
106529610  mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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