KEGG   PATHWAY: aluc00260
Entry
aluc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus luchuensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aluc00260  Glycine, serine and threonine metabolism
aluc00260

Module
aluc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aluc00260]
aluc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aluc00260]
aluc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:aluc00260]
aluc_M00621  Glycine cleavage system [PATH:aluc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus luchuensis [GN:aluc]
Gene
AKAW2_70762S  HOM3; aspartokinase [KO:K00928] [EC:2.7.2.4]
AKAW2_80808A  uncharacterized protein [KO:K00133] [EC:1.2.1.11]
AKAW2_10611S  uncharacterized protein [KO:K00003] [EC:1.1.1.3]
AKAW2_70782A  THR1; trihydroxynaphthalene reductase [KO:K00872] [EC:2.7.1.39]
AKAW2_70223S  THR4; threonine synthase [KO:K01733] [EC:4.2.3.1]
AKAW2_12062S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
AKAW2_60390A  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
AKAW2_11082S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
AKAW2_60736S  SHM1; glycine hydroxymethyltransferase shm1 [KO:K00600] [EC:2.1.2.1]
AKAW2_70258A  SHM2; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
AKAW2_30882S  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AKAW2_70259S  uncharacterized protein [KO:K15633] [EC:5.4.2.12]
AKAW2_40790S  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
AKAW2_61031A  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
AKAW2_70754S  SER3; phosphoglycerate dehydrogenase Ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AKAW2_21531S  SER1; putative secondary metabolism biosynthetic enzyme [KO:K00831] [EC:2.6.1.52]
AKAW2_80840A  uncharacterized protein [KO:K01079] [EC:3.1.3.3]
AKAW2_20424A  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AKAW2_70834S  HEM1; mitochondrial 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
AKAW2_50651S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
AKAW2_60912A  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
AKAW2_61322S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
AKAW2_20373S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
AKAW2_40133A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_60894A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_10048S  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_10922S  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_70961A  CAO1; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AKAW2_11606S  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_20138A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_30128A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
AKAW2_40805A  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
AKAW2_30708S  GCV1; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
AKAW2_11561S  LPD1; dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
AKAW2_30606A  GCV3; glycine cleavage system H-protein subunit [KO:K02437]
AKAW2_41172A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
AKAW2_20429A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
AKAW2_20995A  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AKAW2_70723S  uncharacterized protein [KO:K00130] [EC:1.2.1.8]
AKAW2_60437S  uncharacterized protein [KO:K00309] [EC:1.5.3.10]
AKAW2_30849S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_60932S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_70337A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_10765S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_11650A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_11716A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_30095A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AKAW2_60721A  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AKAW2_70695S  CYS3; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]
AKAW2_40520A  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
AKAW2_51287S  ILV1; threonine deaminase [KO:K01754] [EC:4.3.1.19]
AKAW2_51252A  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AKAW2_40840A  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
AKAW2_70221S  TRP5_2; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
AKAW2_21434A  TRP5_1; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aluc00010  Glycolysis / Gluconeogenesis
aluc00020  Citrate cycle (TCA cycle)
aluc00230  Purine metabolism
aluc00250  Alanine, aspartate and glutamate metabolism
aluc00270  Cysteine and methionine metabolism
aluc00290  Valine, leucine and isoleucine biosynthesis
aluc00300  Lysine biosynthesis
aluc00330  Arginine and proline metabolism
aluc00460  Cyanoamino acid metabolism
aluc00470  D-Amino acid metabolism
aluc00564  Glycerophospholipid metabolism
aluc00600  Sphingolipid metabolism
aluc00620  Pyruvate metabolism
aluc00630  Glyoxylate and dicarboxylate metabolism
aluc00640  Propanoate metabolism
aluc00680  Methane metabolism
aluc00860  Porphyrin metabolism
aluc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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