KEGG   PATHWAY: aoi00260
Entry
aoi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Amycolatopsis keratiniphila
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aoi00260  Glycine, serine and threonine metabolism
aoi00260

Module
aoi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aoi00260]
aoi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aoi00260]
aoi_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:aoi00260]
aoi_M00555  Betaine biosynthesis, choline => betaine [PATH:aoi00260]
aoi_M00621  Glycine cleavage system [PATH:aoi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Amycolatopsis keratiniphila [GN:aoi]
Gene
AORI_7655  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AORI_4036  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AORI_7654  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AORI_6586  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AORI_6584  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
AORI_6585  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AORI_2019  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AORI_7815  ltaA; threonine aldolase [KO:K01620] [EC:4.1.2.48]
AORI_5332  ltaA; threonine aldolase [KO:K01620] [EC:4.1.2.48]
AORI_7527  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AORI_6059  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AORI_6029  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
AORI_1660  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
AORI_0463  gpm; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AORI_5128  gpm; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AORI_6953  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AORI_0166  gpm; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AORI_6227  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AORI_7454  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AORI_7247  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AORI_6508  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AORI_1817  short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AORI_4930  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AORI_4931  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AORI_2942  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
AORI_3584  tynA; primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
AORI_3735  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AORI_6062  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AORI_6061  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
AORI_5758  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AORI_1783  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AORI_6060  gcvH; glycine cleavage system H protein [KO:K02437]
AORI_3729  gcvH; glycine cleavage system H protein [KO:K02437]
AORI_2663  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
AORI_2931  putative multi-domain non-ribosomal peptide synthetase [KO:K00542] [EC:2.1.1.2]
AORI_7346  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
AORI_2600  betA; glucose-methanol-choline oxidoreductase [KO:K17755] [EC:1.1.3.17]
AORI_1198  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AORI_2602  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AORI_2607  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AORI_6212  betB; aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AORI_6809  dehydrogenase [KO:K00309] [EC:1.5.3.10]
AORI_6810  sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
AORI_6932  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AORI_6195  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AORI_6057  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AORI_6007  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AORI_7692  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AORI_6280  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AORI_6491  aspartate racemase [KO:K25316] [EC:5.1.1.10]
AORI_5632  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AORI_5633  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AORI_1728  trpB; tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
AORI_4034  ectB; diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AORI_7382  ectB; diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AORI_7383  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
AORI_7381  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
AORI_7380  ectD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
AORI_5494  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aoi00010  Glycolysis / Gluconeogenesis
aoi00020  Citrate cycle (TCA cycle)
aoi00230  Purine metabolism
aoi00250  Alanine, aspartate and glutamate metabolism
aoi00270  Cysteine and methionine metabolism
aoi00290  Valine, leucine and isoleucine biosynthesis
aoi00300  Lysine biosynthesis
aoi00330  Arginine and proline metabolism
aoi00460  Cyanoamino acid metabolism
aoi00470  D-Amino acid metabolism
aoi00564  Glycerophospholipid metabolism
aoi00600  Sphingolipid metabolism
aoi00620  Pyruvate metabolism
aoi00630  Glyoxylate and dicarboxylate metabolism
aoi00640  Propanoate metabolism
aoi00680  Methane metabolism
aoi00860  Porphyrin metabolism
aoi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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