KEGG   PATHWAY: apla03440
Entry
apla03440                   Pathway                                
Name
Homologous recombination - Anas platyrhynchos (mallard)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
apla03440  Homologous recombination
apla03440

Other DBs
GO: 0000724
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101801333  SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
101800129  RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
101802731  MRE11; double-strand break repair protein MRE11 isoform X2 [KO:K10865]
101802208  NBN; LOW QUALITY PROTEIN: nibrin [KO:K10867]
101803327  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101789679  BRCA1; breast cancer type 1 susceptibility protein isoform X3 [KO:K10605] [EC:2.3.2.27]
101800768  BARD1; BRCA1-associated RING domain protein 1 [KO:K10683]
101798964  RBBP8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
101791710  BRIP1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
101804079  TOPBP1; LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 [KO:K10728]
101798365  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X3 [KO:K20774]
101804226  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
113845646  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
101793627  BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
101800040  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
101799925  PALB2; partner and localizer of BRCA2 [KO:K10897]
101799101  BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
101792212  SYCP3; synaptonemal complex protein 3 [KO:K19528]
101799316  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
101794627  RPA2; replication protein A 32 kDa subunit [KO:K10739]
101797991  RPA3; replication protein A 14 kDa subunit [KO:K10740]
101800716  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
101791025  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
101793904  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
101795896  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
101790122  RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871]
101796468  XRCC2; DNA repair protein XRCC2 [KO:K10879]
101799145  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
101797498  RAD54L; DNA repair and recombination protein RAD54-like isoform X1 [KO:K10875] [EC:5.6.2.-]
101793436  RAD54B; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
119715226  POLD2; LOW QUALITY PROTEIN: DNA polymerase delta subunit 2 [KO:K02328]
101797382  POLD3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 [KO:K03504]
101790058  BLM; LOW QUALITY PROTEIN: Bloom syndrome protein [KO:K10901] [EC:5.6.2.4]
101790026  TOP3A; LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
101800122  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
101801007  EME1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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