KEGG   PATHWAY: aste04141
Entry
aste04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Anopheles stephensi (Asian malaria mosquito)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
aste04141  Protein processing in endoplasmic reticulum
aste04141

Other DBs
GO: 0030433 0034976
Organism
Anopheles stephensi (Asian malaria mosquito) [GN:aste]
Gene
118512545  protein transport protein Sec61 subunit alpha [KO:K10956]
118503543  protein transport protein Sec61 subunit beta [KO:K09481]
118504854  protein transport protein Sec61 subunit gamma [KO:K07342]
118513442  translocation protein SEC62 [KO:K12275]
118516897  translocation protein SEC63 homolog [KO:K09540]
118509108  translocation protein SEC63 homolog [KO:K09540]
118511101  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
118508862  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
118511238  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
118516420  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
118509548  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
118506073  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
118506898  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
118510084  tumor suppressor candidate 3 [KO:K19478]
118514303  putative oligosaccharyltransferase complex subunit CG9662 [KO:K26501]
118513109  transmembrane protein 258 [KO:K26502]
118504831  nucleotide exchange factor Sil1 [KO:K14001]
118506673  hypoxia up-regulated protein 1 [KO:K09486]
118503015  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
118509146  dnaJ homolog shv [KO:K09517]
118510603  uncharacterized protein F54F2.9 [KO:K09521]
118505066  dnaJ homolog subfamily C member 3 [KO:K09523]
118506448  endoplasmin [KO:K09487]
118508312  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
118507842  glucosidase 2 subunit beta [KO:K08288]
118509673  calnexin isoform X1 [KO:K08054]
118512957  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118506357  calreticulin [KO:K08057]
118516626  mannosyl-oligosaccharide alpha-1,2-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
118502543  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
118503375  vesicular integral-membrane protein VIP36 [KO:K10082]
118509443  protein ERGIC-53 [KO:K10080]
118509038  prolactin regulatory element-binding protein [KO:K14003]
118502912  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
118508291  protein SEC13 homolog [KO:K14004]
118503500  protein transport protein Sec31A isoform X1 [KO:K14005]
118507644  protein transport protein Sec23A isoform X1 [KO:K14006]
118509328  protein transport protein Sec24D [KO:K14007]
118512019  protein transport protein Sec24A [KO:K14007]
118505376  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
118510939  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
118511738  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
118503351  protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
118506607  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
118504438  protein windbeutel [KO:K09586]
118509265  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
118505397  ero1-like protein [KO:K10950] [EC:1.8.4.-]
118510662  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
118516456  translocon-associated protein subunit alpha-like [KO:K13249]
118505109  translocon-associated protein subunit alpha-like [KO:K13249]
118511448  translocon-associated protein subunit beta [KO:K13250]
118511722  translocon-associated protein subunit gamma [KO:K13251]
118506741  translocon-associated protein subunit delta [KO:K04571]
118506069  B-cell receptor-associated protein 31-like [KO:K14009]
118516511  B-cell receptor-associated protein 31-like [KO:K14009]
118503316  translocating chain-associated membrane protein 1 [KO:K14010]
118510881  derlin-1 [KO:K11519]
118506392  derlin-2 [KO:K13989]
118513398  UBX domain-containing protein 1-A [KO:K24348]
118516415  UBX domain-containing protein 6-like [KO:K14011]
118509553  UBX domain-containing protein 6-like [KO:K14011]
118509716  NSFL1 cofactor p47 [KO:K14012]
118504746  small VCP/p97-interacting protein [KO:K14014]
118512794  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
118505483  nuclear protein localization protein 4 homolog [KO:K14015]
118507623  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
118507496  heat shock protein 70 A1 [KO:K03283]
118507497  heat shock protein 70 A1 [KO:K03283]
118507498  heat shock protein 70 A1-like [KO:K03283]
118507499  heat shock protein 70 A1-like [KO:K03283]
118507500  heat shock protein 70 A1-like [KO:K03283]
118505701  heat shock 70 kDa protein cognate 4 [KO:K03283]
118505715  heat shock 70 kDa protein cognate 4 [KO:K03283]
118516541  dnaJ homolog subfamily A member 1-like isoform X1 [KO:K09502]
118513042  dnaJ homolog subfamily A member 1-like [KO:K09502]
118506668  dnaJ homolog subfamily B member 14-like [KO:K09518]
118517104  dnaJ homolog subfamily B member 12-like [KO:K09518]
118503680  dnaJ homolog subfamily B member 12-like [KO:K09518]
118512107  dnaJ homolog subfamily C member 5 homolog [KO:K09525]
118514224  heat shock protein 83-like [KO:K04079]
118514225  heat shock protein 83-like [KO:K04079]
118514226  heat shock protein 83 isoform X1 [KO:K04079]
118517669  heat shock 70 kDa protein 4 isoform X1 [KO:K09485]
118503828  BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
118514661  hsp70-binding protein 1 [KO:K09562]
118510278  protein lethal(2)essential for life-like [KO:K09542]
118510279  protein lethal(2)essential for life-like [KO:K09542]
118510280  protein lethal(2)essential for life-like isoform X1 [KO:K09542]
118512872  protein lethal(2)essential for life-like [KO:K09542]
118512873  protein lethal(2)essential for life-like [KO:K09542]
118510419  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
118512466  phospholipase A-2-activating protein [KO:K14018]
118517430  UV excision repair protein RAD23 homolog B-like [KO:K10839]
118504660  ubiquilin-1 [KO:K04523]
118512954  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
118514121  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
118505819  eukaryotic translation initiation factor 2-alpha kinase-like [KO:K08860] [EC:2.7.11.1]
118508237  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
118515250  uncharacterized protein LOC118515250 isoform X1 [KO:K04374]
118510886  uncharacterized protein LOC118510886 isoform X1 [KO:K04374]
118513586  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
118503372  wolframin [KO:K14020]
118517626  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
118507424  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
118517355  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
118507358  uncharacterized protein LOC118507358 [KO:K09027]
118502980  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118517445  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118510750  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
118510751  stress-activated protein kinase JNK-like isoform X1 [KO:K04440] [EC:2.7.11.24]
118517271  E3 ubiquitin-protein ligase MARCHF6-like [KO:K10661] [EC:2.3.2.27]
118510247  E3 ubiquitin-protein ligase MARCHF6-like [KO:K10661] [EC:2.3.2.27]
118513069  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
118506700  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
118504555  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
118508285  E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
118505750  protein sel-1 homolog 1 [KO:K14026]
118512156  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
118513228  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
118502732  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
118514385  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
118509359  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
118513833  cullin-1 [KO:K03347]
118511765  S-phase kinase-associated protein 1-like [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
aste00510  N-Glycan biosynthesis
aste03050  Proteasome
aste03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system