KEGG   PATHWAY: bcew00260
Entry
bcew00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia cenocepacia DWS 37E-2
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bcew00260  Glycine, serine and threonine metabolism
bcew00260

Module
bcew_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bcew00260]
bcew_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bcew00260]
bcew_M00555  Betaine biosynthesis, choline => betaine [PATH:bcew00260]
bcew_M00621  Glycine cleavage system [PATH:bcew00260]
bcew_M00919  Ectoine degradation, ectoine => aspartate [PATH:bcew00260]
bcew_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bcew00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia cenocepacia DWS 37E-2 [GN:bcew]
Gene
DM40_2714  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
DM40_3956  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DM40_2451  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DM40_3876  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
DM40_2450  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
DM40_3262  beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]
DM40_3575  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
DM40_5055  serine hydroxymethyltransferase family protein [KO:K00600] [EC:2.1.2.1]
DM40_1469  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
DM40_3011  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DM40_5802  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DM40_558  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DM40_2345  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DM40_1766  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DM40_2527  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
DM40_459  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DM40_1382  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
DM40_734  putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DM40_4971  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DM40_1703  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
DM40_2380  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DM40_1468  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
DM40_3417  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
DM40_3418  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DM40_917  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
DM40_919  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
DM40_2775  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DM40_1901  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DM40_2137  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DM40_918  gcvH; glycine cleavage system H protein [KO:K02437]
DM40_2911  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DM40_3026  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DM40_3559  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
DM40_3025  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DM40_3004  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
DM40_5022  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
DM40_3008  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
DM40_3007  4Fe-4S dicluster domain protein [KO:K21834]
DM40_3006  electron transfer flavodomain protein [KO:K25960]
DM40_3005  electron transfer flavodomain protein [KO:K25961]
DM40_3053  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DM40_3055  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DM40_3052  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DM40_3054  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DM40_3056  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DM40_915  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DM40_2601  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
DM40_5475  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
DM40_353  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DM40_1911  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
DM40_2783  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
DM40_3962  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
DM40_3960  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
DM40_5477  eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
DM40_5478  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
DM40_5481  aminotransferase [KO:K15785] [EC:2.6.1.76]
DM40_5480  aldehyde dehydrogenase family protein [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bcew00010  Glycolysis / Gluconeogenesis
bcew00020  Citrate cycle (TCA cycle)
bcew00230  Purine metabolism
bcew00250  Alanine, aspartate and glutamate metabolism
bcew00270  Cysteine and methionine metabolism
bcew00290  Valine, leucine and isoleucine biosynthesis
bcew00300  Lysine biosynthesis
bcew00330  Arginine and proline metabolism
bcew00460  Cyanoamino acid metabolism
bcew00470  D-Amino acid metabolism
bcew00564  Glycerophospholipid metabolism
bcew00600  Sphingolipid metabolism
bcew00620  Pyruvate metabolism
bcew00630  Glyoxylate and dicarboxylate metabolism
bcew00640  Propanoate metabolism
bcew00680  Methane metabolism
bcew00860  Porphyrin metabolism
bcew00920  Sulfur metabolism
KO pathway
ko00260   
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