KEGG   PATHWAY: bfo00480
Entry
bfo00480                    Pathway                                
Name
Glutathione metabolism - Branchiostoma floridae (Florida lancelet)
Class
Metabolism; Metabolism of other amino acids
Pathway map
bfo00480  Glutathione metabolism
bfo00480

Module
bfo_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:bfo00480]
Other DBs
GO: 0006749
Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118404798  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118425270  uncharacterized protein LOC118425270 isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118429159  glutathione hydrolase-like YwrD proenzyme isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
118404633  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425266  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425267  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425268  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425271  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425359  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425360  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425971  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118427701  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118417214  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
118418915  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
118417030  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
118404708  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
118405088  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
118419718  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
118417157  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
118426445  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
118418034  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
118422504  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
118414098  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
118405624  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
118412153  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
118405485  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
118410873  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
118411279  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
118418003  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
118418601  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
118417928  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118416067  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118412250  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118412251  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118412313  glutathione S-transferase Mu 6-like [KO:K00799] [EC:2.5.1.18]
118412328  glutathione S-transferase Mu 6-like [KO:K00799] [EC:2.5.1.18]
118407764  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118408505  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
118411522  glutathione S-transferase P-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118424077  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118424311  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118417946  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118418231  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118418358  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118418381  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118418570  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118428170  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118428241  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118429001  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118429002  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118422414  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
118423027  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
118423256  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118423329  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
118407692  uncharacterized protein LOC118407692 [KO:K00799] [EC:2.5.1.18]
118430882  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
118431037  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
118413722  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118414944  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411828  uncharacterized protein LOC118411828 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411829  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412049  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412050  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412051  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412113  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412175  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412337  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412395  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412524  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412719  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118413210  hematopoietic prostaglandin D synthase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405781  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405782  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405835  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118410782  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411000  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118417186  uncharacterized protein LOC118417186 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118427483  probable N-acetyltransferase camello [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118419854  putative N-acetyltransferase 8B [KO:K20838] [EC:2.3.1.80 2.3.1.-]
118426884  glutathione reductase, mitochondrial-like [KO:K00383] [EC:1.8.1.7]
118409495  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
118424129  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
118430769  6-phosphogluconate dehydrogenase, decarboxylating-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
118415985  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
118431775  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
118421311  glutathione peroxidase-like isoform X1 [KO:K05361] [EC:1.11.1.12]
118415291  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
118406955  glutathione peroxidase 7-like [KO:K00432] [EC:1.11.1.9]
118423974  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
118424376  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
118417657  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
118430179  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
118423176  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
118421035  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
118421068  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
118431162  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
118417884  pyrimidodiazepine synthase-like [KO:K00310] [EC:1.5.4.1]
118418016  glutathione S-transferase omega-1-like [KO:K00310] [EC:1.5.4.1]
118418017  glutathione S-transferase omega-1-like [KO:K00310] [EC:1.5.4.1]
118410116  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
118430528  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
118407326  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
118423464  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
118419424  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
118403887  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
118413425  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118407631  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118408543  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118408546  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
118409123  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118409124  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118410080  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118411415  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118424713  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118425643  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118426150  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118426915  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118418062  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
118427594  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118419607  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118428224  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118420137  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118429451  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118422796  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118422797  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118423321  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
118432202  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
PMID:12750367
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
PMID:12967709
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
PMID:12121990
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
PMID:15537651
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
PMID:12751784
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
PMID:18395526
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
PMID:11150302
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
PMID:12949079
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
PMID:12446213
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
PMID:10713147
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
PMID:17922848
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
PMID:12466271
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
PMID:14982633
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
bfo00220  Arginine biosynthesis
bfo00250  Alanine, aspartate and glutamate metabolism
bfo00270  Cysteine and methionine metabolism
bfo00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
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