KEGG   PATHWAY: bgf00260
Entry
bgf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia sp. CCGE1003
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bgf00260  Glycine, serine and threonine metabolism
bgf00260

Module
bgf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bgf00260]
bgf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bgf00260]
bgf_M00555  Betaine biosynthesis, choline => betaine [PATH:bgf00260]
bgf_M00621  Glycine cleavage system [PATH:bgf00260]
bgf_M00919  Ectoine degradation, ectoine => aspartate [PATH:bgf00260]
bgf_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bgf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia sp. CCGE1003 [GN:bgf]
Gene
BC1003_1239  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BC1003_4593  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BC1003_1520  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BC1003_4554  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BC1003_1521  threonine synthase [KO:K01733] [EC:4.2.3.1]
BC1003_2435  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
BC1003_4255  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
BC1003_0487  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BC1003_5876  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BC1003_4693  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BC1003_0191  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BC1003_4338  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BC1003_1871  Gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BC1003_2536  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BC1003_1599  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BC1003_0268  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
BC1003_2929  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BC1003_0064  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BC1003_3555  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BC1003_2606  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BC1003_1565  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BC1003_0486  short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BC1003_4758  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BC1003_4757  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BC1003_3426  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BC1003_3424  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BC1003_1155  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BC1003_1987  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BC1003_5962  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BC1003_3425  glycine cleavage system H protein [KO:K02437]
BC1003_2331  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BC1003_5871  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BC1003_5872  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BC1003_5883  Rieske (2Fe-2S) iron-sulfur domain protein [KO:K00479] [EC:1.14.13.251]
BC1003_5884  Oxidoreductase FAD-binding domain protein [KO:K21832] [EC:1.14.13.251]
BC1003_5879  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
BC1003_5880  protein of unknown function DUF224 cysteine-rich region domain protein [KO:K21834]
BC1003_5881  Electron transfer flavoprotein alpha subunit [KO:K25960]
BC1003_5882  Electron transfer flavoprotein alpha/beta-subunit [KO:K25961]
BC1003_5866  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BC1003_5864  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BC1003_5867  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BC1003_5865  Sarcosine oxidase delta subunit heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BC1003_3428  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
BC1003_5863  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
BC1003_0365  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BC1003_1583  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
BC1003_1828  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BC1003_5083  ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
BC1003_0359  alanine racemase domain protein [KO:K01753] [EC:4.3.1.18]
BC1003_1146  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BC1003_4587  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BC1003_4589  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BC1003_5085  ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
BC1003_5086  ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
BC1003_5089  aminotransferase class-III [KO:K15785] [EC:2.6.1.76]
BC1003_5088  Aldehyde Dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bgf00010  Glycolysis / Gluconeogenesis
bgf00020  Citrate cycle (TCA cycle)
bgf00230  Purine metabolism
bgf00250  Alanine, aspartate and glutamate metabolism
bgf00270  Cysteine and methionine metabolism
bgf00290  Valine, leucine and isoleucine biosynthesis
bgf00300  Lysine biosynthesis
bgf00330  Arginine and proline metabolism
bgf00460  Cyanoamino acid metabolism
bgf00470  D-Amino acid metabolism
bgf00564  Glycerophospholipid metabolism
bgf00620  Pyruvate metabolism
bgf00630  Glyoxylate and dicarboxylate metabolism
bgf00640  Propanoate metabolism
bgf00680  Methane metabolism
bgf00860  Porphyrin metabolism
bgf00920  Sulfur metabolism
KO pathway
ko00260   
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