KEGG   PATHWAY: breg04142
Entry
breg04142                   Pathway                                
Name
Lysosome - Balearica regulorum gibbericeps (East African grey crowned-crane)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
breg04142  Lysosome
breg04142

Other DBs
GO: 0005764
Organism
Balearica regulorum gibbericeps (East African grey crowned-crane) [GN:breg]
Gene
104630106  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
104636942  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
104643361  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
104630305  V-type proton ATPase subunit d 1 [KO:K02146]
104634542  V-type proton ATPase subunit d 2 [KO:K02146]
104643168  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104633251  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
104631572  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104639473  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104636819  dmX-like protein 2 [KO:K24155]
104634094  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
104629657  WDR7; WD repeat-containing protein 7 [KO:K24738]
104637857  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
104638518  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
104638925  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
104632432  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
104640534  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
104636840  cathepsin E-A-like [KO:K01382] [EC:3.4.23.34]
104634693  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
104633746  LOW QUALITY PROTEIN: mast cell protease 1A-like [KO:K01319] [EC:3.4.21.20]
104629162  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
104632109  LOW QUALITY PROTEIN: cathepsin K-like [KO:K01371] [EC:3.4.22.38]
104642690  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
104630192  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
104632098  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
104636328  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
104640499  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
104634407  TPP1; LOW QUALITY PROTEIN: tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
104634021  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
104640927  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
104629906  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
104631008  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
104633263  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
104629509  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
104637604  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
104642256  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
104629546  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
104629826  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
104643754  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
104641036  LOW QUALITY PROTEIN: hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
104636540  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
104637073  LOW QUALITY PROTEIN: hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
104633729  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
104632123  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
104637536  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
104636034  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
104640341  GNS; LOW QUALITY PROTEIN: N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
104629553  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
104642054  lipase member K-like [KO:K01052] [EC:3.1.1.13]
104633349  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
104642626  putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104637933  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104630507  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
104630627  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
104643443  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
104637088  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
104640006  PSAP; prosaposin [KO:K12382]
104634324  GM2A; LOW QUALITY PROTEIN: ganglioside GM2 activator [KO:K12383]
104629097  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
104636024  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
104630158  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
104641192  lysosome-associated membrane glycoprotein 3-like [KO:K06562]
104638904  SCARB2; LOW QUALITY PROTEIN: lysosome membrane protein 2 [KO:K12384]
104632886  NPC1; Niemann-Pick C1 protein [KO:K12385]
104634719  NPC2; epididymal secretory protein E1 [KO:K13443]
104630280  CTNS; cystinosin [KO:K12386]
104637601  SLC17A5; sialin [KO:K12301]
104638319  natural resistance-associated macrophage protein 1-like [KO:K12347]
104638476  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
104636877  LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
104637521  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
104630656  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
104633269  LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2-like [KO:K05642]
104643284  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
104633666  sialomucin core protein 24-like [KO:K06546]
104635952  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
104641290  SORT1; sortilin [KO:K12388]
104629139  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
104629926  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
104634254  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
104635092  SUMF1; sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
104634102  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
104629852  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
104637506  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
104637354  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
104635145  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104641098  CLTA; clathrin light chain A [KO:K04644]
104643399  CLTB; LOW QUALITY PROTEIN: clathrin light chain B [KO:K04645]
104634043  clathrin heavy chain 1-like isoform X1 [KO:K04646]
104634767  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
104637249  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
104642614  AP1B1; LOW QUALITY PROTEIN: AP-1 complex subunit beta-1 [KO:K12392]
104639900  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
104631683  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
104642238  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
104639233  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
104637672  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
104642498  AP3B1; LOW QUALITY PROTEIN: AP-3 complex subunit beta-1 [KO:K12397]
104641489  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
104643154  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
104635500  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
104641521  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
104638912  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
104640479  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
104640674  GGA3; LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
104642318  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
104631416  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
104642908  MCOLN1; mucolipin-1 [KO:K04992]
104628978  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
breg00511  Other glycan degradation
breg00531  Glycosaminoglycan degradation
breg04130  SNARE interactions in vesicular transport
breg04140  Autophagy - animal
breg04144  Endocytosis
KO pathway
ko04142   
LinkDB

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